AC T01838
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ID T01838
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DT 05.06.1996 (created); dbo.
DT 11.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA Sox-4
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SY Sox-4; SOX4; SRY-box containing gene 4.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002878 Sox4.
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CL C0015; HMG.
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SZ 440 AA; 45.2 kDa (cDNA) (calc.).
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SQ MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIK
SQ RPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIQEAERLRLKHM
SQ ADYPDYKYRPRKKVKSGNAGAGSAATAKPGEKGDKVAGSSGHAGSSHAGGGAGGTSKPTP
SQ KKSCGPKVAGSSVGKPHAKLVPAGGSKAAASFSPEQAALLPLGEPTAVYKVRTPQLATPA
SQ ASSSPSSALATPAKHPADKKVKHVYLFGSLGASASPVGGLGACADPSDPLGLYEDGGPGC
SQ SPDGRSLSGRSSAASSPAASRSPADHRGYASLRAASPAPSSAPSHASSSLSSSSSSSSGS
SQ SSSDDEFEDDLLDLNPSSNFESMSLGSFSSSSALDRDLDFNFEPGSGSHFEFPDYCTPEV
SQ SEMISGDWLESSISNLVFTY
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SC Swiss-Prot#Q06831
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FT 58 128 
SM00398; hmgende2.
FT 59 127 
PF00505; HMG (high mobility group) box.
FT 59 127 
PS50118; HMG_BOX_2.
FT 76 385 
PF00478; IMP dehydrogenase / GMP reductase domain.
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SF serine-rich C-terminal part is the trans-activating domain [3];
SF 30-fold higher affinity for specific DNA (AACAAAG, KD = 0.3 pM) than for unspecific DNA (KD = 1 nM) [1];
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CP ovary, testis, thymus, very low in heart, lung, lymph nodes, pre-B and T-cell lines [3].
CN brain, gut, kidney, liver, muscle, salivary gland, spleen [3].
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FF activator [3];
FF bends DNA [1];
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IN T08474 beta-catenin-isoform1; human, Homo sapiens.
IN T02918 TCF-4; human, Homo sapiens.
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MX M01308 V$SOX4_01.
MX M07614 V$SOX4_Q3.
MX M03849 V$SOX4_Q5.
MX M07268 V$SOX4_Q5_02.
MX M08899 V$SOX_Q4.
MX M01014 V$SOX_Q6.
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BS R15187.
BS R22674.
BS R22673.
BS R03576.
BS R21480.
BS R33555.
BS R69791.
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DR TRANSPATH: MO000045455.
DR EMBL: X70298;
DR UniProtKB: Q06831;
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RN [1]; RE0001063.
RX PUBMED: 8227043.
RA Dooijes D., van de Wetering M., Knippels L., Clevers H.
RT The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-specific DNA-binding high mobility group box protein
RL J. Biol. Chem. 268:24813-24817 (1993).
RN [2]; RE0004341.
RX PUBMED: 1614875.
RA Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.
RT A conserved family of genes related to the testis determining gene, SRY
RL Nucleic Acids Res. 20:2887-2887 (1992).
RN [3]; RE0004356.
RX PUBMED: 8404853.
RA van de Wetering M., Oosterwegel M., van Norren K., Clevers H.
RT Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes
RL EMBO J. 12:3847-3854 (1993).
RN [4]; RE0004357.
RX PUBMED: 8493110.
RA Schilham M. W., van Eijk M., van de Wetering M., Clevers H. C.
RT The murine Sox-4 protein is encoded on a single exon
RL Nucleic Acids Res. 21:2009-2009 (1993).
RN [5]; RE0017072.
RX PUBMED: 9730625.
RA Critcher R., Stitson R. N., Wade-Martins R., Easty D. J., Farr C. J.
RT Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement2 of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3
RL Cytogenet. Cell Genet. 81:294-295 (1998).
RN [6]; RE0067112.
RX PUBMED: 17875931.
RA Sinner D., Kordich J. J., Spence J. R., Opoka R., Rankin S., Lin S. C., Jonatan D., Zorn A. M., Wells J. M.
RT Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells.
RL Mol. Cell. Biol. 27:7802-7815 (2007).
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