TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01838 XX ID T01838 XX DT 05.06.1996 (created); dbo. DT 11.01.2016 (updated); mkl. CO Copyright (C), QIAGEN. XX FA Sox-4 XX SY Sox-4; SOX4; SRY-box containing gene 4. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G002878 Sox4. XX CL C0015; HMG. XX SZ 440 AA; 45.2 kDa (cDNA) (calc.). XX SQ MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIK SQ RPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIQEAERLRLKHM SQ ADYPDYKYRPRKKVKSGNAGAGSAATAKPGEKGDKVAGSSGHAGSSHAGGGAGGTSKPTP SQ KKSCGPKVAGSSVGKPHAKLVPAGGSKAAASFSPEQAALLPLGEPTAVYKVRTPQLATPA SQ ASSSPSSALATPAKHPADKKVKHVYLFGSLGASASPVGGLGACADPSDPLGLYEDGGPGC SQ SPDGRSLSGRSSAASSPAASRSPADHRGYASLRAASPAPSSAPSHASSSLSSSSSSSSGS SQ SSSDDEFEDDLLDLNPSSNFESMSLGSFSSSSALDRDLDFNFEPGSGSHFEFPDYCTPEV SQ SEMISGDWLESSISNLVFTY XX SC Swiss-Prot#Q06831 XX FT 58 128 SM00398; hmgende2. FT 59 127 PF00505; HMG (high mobility group) box. FT 59 127 PS50118; HMG_BOX_2. FT 76 385 PF00478; IMP dehydrogenase / GMP reductase domain. XX SF serine-rich C-terminal part is the trans-activating domain [3]; SF 30-fold higher affinity for specific DNA (AACAAAG, KD = 0.3 pM) than for unspecific DNA (KD = 1 nM) [1]; XX CP ovary, testis, thymus, very low in heart, lung, lymph nodes, pre-B and T-cell lines [3]. CN brain, gut, kidney, liver, muscle, salivary gland, spleen [3]. XX FF activator [3]; FF bends DNA [1]; XX IN T08474 beta-catenin-isoform1; human, Homo sapiens. IN T02918 TCF-4; human, Homo sapiens. XX MX M01308 V$SOX4_01. MX M07614 V$SOX4_Q3. MX M03849 V$SOX4_Q5. MX M07268 V$SOX4_Q5_02. MX M08899 V$SOX_Q4. MX M01014 V$SOX_Q6. XX BS R15187. BS R22674. BS R22673. BS R03576. BS R21480. BS R33555. BS R69791. XX DR TRANSPATH: MO000045455. DR EMBL: X70298; DR UniProtKB: Q06831; XX RN [1]; RE0001063. RX PUBMED: 8227043. RA Dooijes D., van de Wetering M., Knippels L., Clevers H. RT The Schizosaccharomyces pombe mating-type gene mat-Mc encodes a sequence-specific DNA-binding high mobility group box protein RL J. Biol. Chem. 268:24813-24817 (1993). RN [2]; RE0004341. RX PUBMED: 1614875. RA Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A. RT A conserved family of genes related to the testis determining gene, SRY RL Nucleic Acids Res. 20:2887-2887 (1992). RN [3]; RE0004356. RX PUBMED: 8404853. RA van de Wetering M., Oosterwegel M., van Norren K., Clevers H. RT Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes RL EMBO J. 12:3847-3854 (1993). RN [4]; RE0004357. RX PUBMED: 8493110. RA Schilham M. W., van Eijk M., van de Wetering M., Clevers H. C. RT The murine Sox-4 protein is encoded on a single exon RL Nucleic Acids Res. 21:2009-2009 (1993). RN [5]; RE0017072. RX PUBMED: 9730625. RA Critcher R., Stitson R. N., Wade-Martins R., Easty D. J., Farr C. J. RT Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement2 of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3 RL Cytogenet. Cell Genet. 81:294-295 (1998). RN [6]; RE0067112. RX PUBMED: 17875931. RA Sinner D., Kordich J. J., Spence J. R., Opoka R., Rankin S., Lin S. C., Jonatan D., Zorn A. M., Wells J. M. RT Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. RL Mol. Cell. Biol. 27:7802-7815 (2007). XX //