AC T02512
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ID T02512
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DT 29.07.1998 (created); tme.
DT 23.09.2015 (updated); hna.
CO Copyright (C), QIAGEN.
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FA HNF-3alpha
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SY FOXA1; Hepatocyte Nuclear Factor 3 alpha; HNF3A.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004704 FOXA1; HGNC: FOXA1.
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CL C0023; fork head; 3.3.1.1.1.
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CP (adult) pullmonary (NCI-H441, Ishikawa, A549), hepatic (HepG2), and breast (MCF-7 and MD468)cell lines; expression in breast cancer cell lines (MCF7, T-47D, ZR-75-1 and BT474) [4].
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FF FOXA1 protein expression is enhanced by coexpression with BRCA1T04074 and cotransfection of BRCA1 with FOXA1 increases the half-life of FOXA1 protein suggesting that BRCA1 might be stabilizing FOXA1 protein [4];
FF FoxA1 and FoxD3 T04167 show an additive, not synergistic, activation of the FoxA1 promoter R16330 [3];
FF Oct4 T00652 inhibits almost completely the activation of the FoxA1 promoter by FoxD3 [3];
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IN T00040 AR; human, Homo sapiens.
IN T04074 brca1; human, Homo sapiens.
IN T02918 TCF-4; human, Homo sapiens.
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MX M04737 V$FOXA1_02.
MX M04789 V$FOXA1_03.
MX M04912 V$FOXA1_04.
MX M04927 V$FOXA1_05.
MX M04930 V$FOXA1_06.
MX M08764 V$FOXA1_07.
MX M00724 V$HNF3ALPHA_Q6.
MX M01261 V$HNF3A_01.
MX M03827 V$HNF3A_Q6.
MX M00791 V$HNF3_Q6.
MX M01012 V$HNF3_Q6_01.
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BS R38155.
BS R38156.
BS R38157.
BS R38158.
BS R20251.
BS R26381.
BS R20790.
BS R30058.
BS R30059.
BS R66118.
BS R64410.
BS R39739.
BS R19711.
BS R28353.
BS R04663.
BS R69765.
BS R69766.
BS R26540.
BS R39567.
BS R39568.
BS R68220.
BS R68223.
BS R68224.
BS R68225.
BS R13180.
BS R13181.
BS R04656.
BS R26311.
BS R57882.
BS R30993.
BS R18677.
BS R12970.
BS R26428.
BS R16330.
BS R26408.
BS R39339.
BS R39340.
BS R05019.
BS R08894.
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DR TRANSPATH: MO000026492.
DR UniProtKB: P55317;
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RN [1]; RE0006655.
RA TRANSFAC_Team.
RT Revisions of transcription factor domains
RL TRANSFAC Reports 1:0002 (1998).
RN [2]; RE0006955.
RX PUBMED: 8652662.
RA Bingle C. D., Gowan S.
RT Molecular cloning of the forkhead transcription factor HNF-3alpha from a human pulmonary adenocarcinoma cell line
RL Biochim. Biophys. Acta 1307:17-20 (1996).
RN [3]; RE0025441.
RX PUBMED: 11891324.
RA Guo Y., Costa R., Ramsey H., Starnes T., Vance G., Robertson K., Kelley M., Reinbold R., Scholer H., Hromas R.
RT The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression.
RL Proc. Natl. Acad. Sci. USA 99:3663-3667 (2002).
RN [4]; RE0035617.
RX PUBMED: 16331276.
RA Williamson E. A., Wolf I., Okelly J., Bose S., Tanosaki S., Koeffler H. P.
RT BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1).
RL Oncogene 25:1391-1319 (2006).
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