TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02512 XX ID T02512 XX DT 29.07.1998 (created); tme. DT 23.09.2015 (updated); hna. CO Copyright (C), QIAGEN. XX FA HNF-3alpha XX SY FOXA1; Hepatocyte Nuclear Factor 3 alpha; HNF3A. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004704 FOXA1; HGNC: FOXA1. XX CL C0023; fork head; XX CP (adult) pullmonary (NCI-H441, Ishikawa, A549), hepatic (HepG2), and breast (MCF-7 and MD468)cell lines; expression in breast cancer cell lines (MCF7, T-47D, ZR-75-1 and BT474) [4]. XX FF FOXA1 protein expression is enhanced by coexpression with BRCA1T04074 and cotransfection of BRCA1 with FOXA1 increases the half-life of FOXA1 protein suggesting that BRCA1 might be stabilizing FOXA1 protein [4]; FF FoxA1 and FoxD3 T04167 show an additive, not synergistic, activation of the FoxA1 promoter R16330 [3]; FF Oct4 T00652 inhibits almost completely the activation of the FoxA1 promoter by FoxD3 [3]; XX IN T00040 AR; human, Homo sapiens. IN T04074 brca1; human, Homo sapiens. IN T02918 TCF-4; human, Homo sapiens. XX MX M04737 V$FOXA1_02. MX M04789 V$FOXA1_03. MX M04912 V$FOXA1_04. MX M04927 V$FOXA1_05. MX M04930 V$FOXA1_06. MX M08764 V$FOXA1_07. MX M00724 V$HNF3ALPHA_Q6. MX M01261 V$HNF3A_01. MX M03827 V$HNF3A_Q6. MX M00791 V$HNF3_Q6. MX M01012 V$HNF3_Q6_01. XX BS R38155. BS R38156. BS R38157. BS R38158. BS R20251. BS R26381. BS R20790. BS R30058. BS R30059. BS R66118. BS R64410. BS R39739. BS R19711. BS R28353. BS R04663. BS R69765. BS R69766. BS R26540. BS R39567. BS R39568. BS R68220. BS R68223. BS R68224. BS R68225. BS R13180. BS R13181. BS R04656. BS R26311. BS R57882. BS R30993. BS R18677. BS R12970. BS R26428. BS R16330. BS R26408. BS R39339. BS R39340. BS R05019. BS R08894. XX DR TRANSPATH: MO000026492. DR UniProtKB: P55317; XX RN [1]; RE0006655. RA TRANSFAC_Team. RT Revisions of transcription factor domains RL TRANSFAC Reports 1:0002 (1998). RN [2]; RE0006955. RX PUBMED: 8652662. RA Bingle C. D., Gowan S. RT Molecular cloning of the forkhead transcription factor HNF-3alpha from a human pulmonary adenocarcinoma cell line RL Biochim. Biophys. Acta 1307:17-20 (1996). RN [3]; RE0025441. RX PUBMED: 11891324. RA Guo Y., Costa R., Ramsey H., Starnes T., Vance G., Robertson K., Kelley M., Reinbold R., Scholer H., Hromas R. RT The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. RL Proc. Natl. Acad. Sci. USA 99:3663-3667 (2002). RN [4]; RE0035617. RX PUBMED: 16331276. RA Williamson E. A., Wolf I., Okelly J., Bose S., Tanosaki S., Koeffler H. P. RT BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1). RL Oncogene 25:1391-1319 (2006). XX //