AC T00652
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ID T00652
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DT 27.01.1993 (created); hse.
DT 21.01.2015 (updated); ros.
CO Copyright (C), QIAGEN.
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FA Oct3-isoform1
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SY DADB-104B20.2; MGC22487; Oct-3; Oct-3A; Oct-4; OCT3; Oct4; Otf-3; OTF3; OTF4; POU class 5 homeobox 1; POU domain, class 5, transcription factor 1; POU5F1; POU5F1A; POU5F1B.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002472 POU5F1; HGNC: POU5F1.
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CL C0007; POU; 3.1.10.5.1.1.
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SZ 360 AA; 38.6 kDa (cDNA) (calc.), 42, 35 kDa (SDS)
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SQ MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWLSFQGPPGGPGIGPGVGPGSEVWGI
SQ PPCPPPYEFCGGMAYCGPQVGVGLVPQGGLETSQPEGEAGVGVESNSDGASPEPCTVTPG
SQ AVKLEKEKLEQNPEESQDIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFS
SQ QTTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQARKRKRTSIENR
SQ VRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYAQREDFEA
SQ AGSPFSGGPVSFPLAPGPHFGTPGYGSPHFTALYSSVPFPEGEAFPPVSVTTLGSPMHSN
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SC Swiss-Prot#Q01860-1
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FT 138 212 
PF00157; Pou domain - N-terminal to homeobox domain.
FT 138 212 
SM00352; pou.
FT 228 288 
PS50071; HOMEOBOX_2.
FT 228 290 
PS50550; POU_HOMEODOMAIN.
FT 230 292 
SM00389; HOX_1.
FT 231 287 
PF00046; Homeobox domain.
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SF exists in a major (42 kDa) and a minor (35 kDa) form;
SF a splice variant is POU5F1B (Oct-3B) T01872, whereas POU5F1C (Oct-3C) T04471 is the product of a distinct gene [3];
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CP embryonic cells, adult heart, kidney, liver, ovary and testis [3]; embryonic stem cells [4] [4] [3]; germ cells, embryonic stem cells, whole embryo at various stages of development [5].
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FF activator [1];
FF although Oct4 could not bind the FoxA1 R16330 or FoxA2 R16331 promoters, it could repress FoxD3 T04167 activation of those promoters [4];
FF Oct4 alone does not inhibit FoxA1 T02512 or FoxA2 T02513acitvation of its own promoters, as it did with FoxD3 T04167 [4];
FF Oct4 inhibits almost completely the activation of the FoxA1 and FoxA2 promoter by FoxD3 T04167 [4];
FF interaction between FoxD3 and Oct4, which implies that when Oct4 is not binding to DNA it can function as a corepressor to inhibit the lineage-specific promoter used [4];
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IN T14243 GKLF; human, Homo sapiens.
IN T04167 HFH2; human, Homo sapiens.
IN T00652 Oct3-isoform1; human, Homo sapiens.
IN T04915 Sox-2; human, Homo sapiens.
IN T09970 Sox-2; human, Homo sapiens.
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MX M03837 V$OCT3_Q6.
MX M01125 V$OCT4_01.
MX M01124 V$OCT4_02.
MX M00795 V$OCT_Q6.
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BS R16329.
BS R02227.
BS R16330.
BS R16331.
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DR TRANSPATH: MO000046031.
DR EMBL: Z11898; HSOTF3AMR.
DR EMBL: Z11900; HSOTF3G.
DR UniProtKB: Q01860-1;
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RN [1]; RE0000424.
RX PUBMED: 2573524.
RA Schoeler H. R., Balling R., Hatzopoulos A. K., Suzuki N., Gruss P.
RT Octamer binding proteins confer transcriptional activity in early mouse embryogenesis
RL EMBO J. 8:2551-2557 (1989).
RN [2]; RE0004221.
RX PUBMED: 2739723.
RA He X., Treacy M. N., Simmons D. M., Ingraham H. A., Swanson L. W., Rosenfeld M. G.
RT Expression of a large family of POU-domain regulatory genes in mammalian brain development
RL Nature 340:35-42 (1989).
RN [3]; RE0004391.
RX PUBMED: 1408763.
RA Takeda J., Seino S., Bell G. I.
RT Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues
RL Nucleic Acids Res. 20:4613-4620 (1992).
RN [4]; RE0025441.
RX PUBMED: 11891324.
RA Guo Y., Costa R., Ramsey H., Starnes T., Vance G., Robertson K., Kelley M., Reinbold R., Scholer H., Hromas R.
RT The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression.
RL Proc. Natl. Acad. Sci. USA 99:3663-3667 (2002).
RN [5]; RE0047687.
RX PUBMED: 11044462.
RA Hansis C., Grifo J. A., Krey L. C.
RT Oct-4 expression in inner cell mass and trophectoderm of human blastocysts.
RL Mol. Hum. Reprod. 6:999-1004 (2000).
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