AC T02878
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ID T02878
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DT 13.01.2000 (created); sur.
DT 19.06.2013 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA TCF-4E
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SY hTCF-4E; human TCF-4E; TCF7L2; transcription factor-7-like-2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004017 TCF7L2; HGNC: TCF7L2.
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CL C0015; HMG.
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SZ 596 AA; 65.4 kDa (cDNA) (calc.).
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SQ MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS
SQ DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS
SQ LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL
SQ ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQ
SQ QGQPVYPITTGGFRHPYPTALTVNASVSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQES
SQ SQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQI
SQ LGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSE
SQ CFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSD
SQ GSLLDSPPPSPNLLGSPPRDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEATHK
SQ ASALCPNGALDLPPAALQPAAPSSSIAQPSTSWLHSHSSLAGTQPQPLSLVTKSLE
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SC TREMBL #O00185
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FT 176 359 
Grg-5 binding domain [4].
FT 326 396 
SM00398; hmgende2.
FT 327 400 
HMG domain [2].
FT 327 395 
PF00505; HMG (high mobility group) box.
FT 327 395 
PS50118; HMG_BOX_2.
FT 417 433 
missing in TCF-4E (mouse) [6].
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SF not expressed in cells of the lymphoid lineage [1];
SF member of Wnt-signal transduction cascade [3];
SF RT-PCR assay for expression of TCF genes in colon tumor cells showed that only TCF-4 mRNA was expressed in all lines [2];
SF in APC -/- colon carcinoma cells transcription activity arose 5 - 20 times [2];
SF cotransfection with APC expression vector abrogated increased transcriptional activity;
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FF reporter gene assays showed interaction of TCF-4 N terminus with beta-catenin resulting in transcriptional activation;
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IN T02872 beta-catenin; human, Homo sapiens.
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MX M00671 V$TCF4_Q5.
MX M04633 V$TCF4_Q5_02.
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BS R08642.
BS R08643.
BS R08644.
BS R08645.
BS R08646.
BS R56532.
BS R56537.
BS R56538.
BS R56572.
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DR TRANSPATH: MO000026846.
DR EMBL: Y11306;
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RN [1]; RE0007924.
RX PUBMED: 1741298.
RA Castrop J., van Norren K., Clevers H.
RT A gene family of HMG-box transcription factors with homology to TCF-1
RL Nucleic Acids Res. 20:611 (1992).
RN [2]; RE0014030.
RX PUBMED: 9065401.
RA Korinek V., Barker N., Morin P. J., van Wichen D., de Weger R., Kinzler K. W., Vogelstein B., Clevers H.
RT Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
RL Science 275:1784-1787 (1997).
RN [3]; RE0014033.
RX PUBMED: 10489374.
RA Roose J., Huls G., van Beest M., Moerer P., van der Horn K., Goldschmeding R., Logtenberg T., Clevers H.
RT Synergy Between Tumor Suppressor APC and the beta-Catenin-Tcf4 Target Tcf1
RL Science 285:1923-1926 (1999).
RN [4]; RE0014087.
RX PUBMED: 9783587.
RA Roose J., Molenaar M., Peterson J., Hurenkamp J., Brantjes H., Moerer P., van de Wetering M., Destree O., Clevers H.
RT The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
RL Nature 395:608-612 (1998).
RN [5]; RE0014088.
RX PUBMED: 9488439.
RA Korinek V., Barker N., Willert K., Molenaar M., Roose J., Wagenaar G., Markman M., Lamers W., Destree O., Clevers H.
RT Two members of the Tcf family implicated in Wnt/beta-Catenin signaling during embryogenesis in the mouse
RL Mol. Cell. Biol. 18:1248-1256 (1998).
RN [6]; RE0014557.
RX PUBMED: 9880534.
RA Lee Y. J., Swencki B., Shoichet S., Shivdasani R. A.
RT A possible role for the high mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation
RL J. Biol. Chem. 274:1566-1572 (1999).
RN [7]; RE0014765.
RX PUBMED: 10756202.
RA Hovanes K., Li T. W. H., Waterman M. L.
RT The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing
RL Nucleic Acids Res. 28:1994-2003 (2000).
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