AC T02917
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ID T02917
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DT 28.01.2000 (created); sur.
DT 17.02.2005 (updated); vma.
CO Copyright (C), QIAGEN.
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FA TCF-4B
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SY hTCF-4B; human TCF-4B; TCF7L2; transcription factor-7-like-2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004017 TCF7L2; HGNC: TCF7L2.
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CL C0015; HMG.
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SZ 442 AA; 49.1 kDa (cDNA) (calc.).
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SQ MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSS
SQ DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS
SQ LSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL
SQ ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQ
SQ QGQPVYPITTGGFRHPYPTALTVNASVSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQES
SQ SQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQI
SQ LGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNGEKK
SQ SAFATYKVKAAASAHPLQMEAY
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SC TREMBL #O00185; modified according to [2]; AA 410 Q instead of K [4]
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FT 1 53 
N terminal interaction domain [2].
FT 326 396 
SM00398; hmgende2.
FT 327 400 
HMG domain [2].
FT 327 395 
PF00505; HMG (high mobility group) box.
FT 327 395 
PS50118; HMG_BOX_2.
FT 402 442 
identical to TCF-4B (mouse) AA 408-448 [4].
FT 417 442 
B tail [5].
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SF not expressed in cells of the lymphoid lineage [1];
SF pI 8.74;
SF member of Wnt-signal transduction cascade [3];
SF RT-PCR assay for expression of TCF genes in colon tumor cells showed that only TCF-4 mRNA was expressed in all lines [2];
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FF interaction of the N terminus of TCF-4 with beta-catenin results in transcriptional activation (of reporter genes) [2];
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IN T02872 beta-catenin; human, Homo sapiens.
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MX M00671 V$TCF4_Q5.
MX M04633 V$TCF4_Q5_02.
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DR TRANSPATH: MO000026881.
DR EMBL: Y11306;
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RN [1]; RE0007924.
RX PUBMED: 1741298.
RA Castrop J., van Norren K., Clevers H.
RT A gene family of HMG-box transcription factors with homology to TCF-1
RL Nucleic Acids Res. 20:611 (1992).
RN [2]; RE0014030.
RX PUBMED: 9065401.
RA Korinek V., Barker N., Morin P. J., van Wichen D., de Weger R., Kinzler K. W., Vogelstein B., Clevers H.
RT Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
RL Science 275:1784-1787 (1997).
RN [3]; RE0014033.
RX PUBMED: 10489374.
RA Roose J., Huls G., van Beest M., Moerer P., van der Horn K., Goldschmeding R., Logtenberg T., Clevers H.
RT Synergy Between Tumor Suppressor APC and the beta-Catenin-Tcf4 Target Tcf1
RL Science 285:1923-1926 (1999).
RN [4]; RE0014557.
RX PUBMED: 9880534.
RA Lee Y. J., Swencki B., Shoichet S., Shivdasani R. A.
RT A possible role for the high mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation
RL J. Biol. Chem. 274:1566-1572 (1999).
RN [5]; RE0014765.
RX PUBMED: 10756202.
RA Hovanes K., Li T. W. H., Waterman M. L.
RT The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing
RL Nucleic Acids Res. 28:1994-2003 (2000).
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