TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02984 XX ID T02984 XX DT 23.02.2000 (created); sur. DT 12.06.2015 (updated); msr. CO Copyright (C), QIAGEN. XX FA beta-catenin XX SY beta-catenin; CATNB; CTNNB1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005040 Ctnnb1. XX HO armadillo (Drosophila melanogaster). XX SF 2 major functions: it binds to cytoplasmic domain of cadherin and alpha-catenin which binds to actin; SF this complex is a target of regulatory signals that govern cellular adhesiveness and mobility; SF component of the Wnt/ Wingless growth factor signaling pathway as it can form complexes with the member of the Tcf/Lef-1 family of transcription factors; SF extended, acidic regions of cadherins, APC and Tcf/Lef-1 family transcription factors might interact with the basic groove of beta-catenin; SF binds to alpha-catenin; SF beta-catenin lacking aa 1-131 or having aa substitutions in the N terminus (S33->A, S37->A, T40->A, S45->A, S47->A) showed higher activation of a reporter gene than the wt beta-catenin [5]; SF for the interaction of beta-catenin and LEF-1 the HMG domain of LEF-1 is not essential [1]; SF circular permutation analysis of DNA bending induced by LEF-1 or the beta-catenin/ LEF-1 complex showed that beta-catenin decreased the extent of LEF-1 induced DNA bending (from ~ 120� to ~ 80�) [1]; XX FF Cdc42 activation leads to stable cadherin-catenin complex formation by suppressing IQGAP1 function in vivo (transfected EL cells) as well as in vitro [10]; FF transcriptional coactivator, interacts APC, cadherins, TCF/LEF family transcriptional factors and the EGF receptor tyrosine kinase domain; FF interaction in all cases appears within the armadillo repeat region; FF E-cadherin and APC seem to compete for binding to beta-catenin [3]; FF a truncated protein bearing the N terminus and armadillo repeats 1-7 seem to be partly sufficient for binding to LEF-1 but higher affinity was seen with a truncated protein only consisting of armadillo repeats 1-13 or the whole protein [1]; FF loss of regulation of beta-catenin levels seems to be an important step in oncogenic transformation [3]; FF amino- and carboxyl- terminal regions of beta-catenin contain transcriptional activation domains which could function in a heterologous context by collaboration with one another or with LEF-1 [5]; FF the transcriptional activation domains of beta-catenin can functionally collaborate with protein domains of DNA-bound LEF-1 to stimulate transcription [5]; XX IN T00041 AR; mouse, Mus musculus. IN T02450 GKLF; mouse, Mus musculus. IN T02905 LEF-1-isoform1; human, Homo sapiens. IN T00930 LEF-1; mouse, Mus musculus. IN T09551 LEF-1; Mammalia. IN T09576 LEF-1; mouse, Mus musculus. IN T25301 lmo7; mouse, Mus musculus. IN T01427 p300; human, Homo sapiens. IN T10542 p300; mouse, Mus musculus. IN T08551 SF-1; mouse, Mus musculus. IN T32110 SIRT1; mouse, Mus musculus. IN T04254 Smad1; mouse, Mus musculus. IN T34106 Smad1{p}; mouse, Mus musculus. IN T01111 TCF-3; mouse, Mus musculus. IN T02915 TCF-4-isoform1; mouse, Mus musculus. IN T02918 TCF-4; human, Homo sapiens. IN T08958 TCF-4; mouse, Mus musculus. IN T11303 UBTF; mouse, Mus musculus. XX MX M03539 V$BETACATENIN_Q3. MX M07376 V$BETACATENIN_Q3_01. MX M07035 V$BETACATENIN_Q6. MX M07599 V$BETACATENIN_Q6_01. XX BS R26562. BS R67618. BS R67616. BS R56961. BS R56962. BS R56963. BS R56964. BS R67723. BS R67628. BS R67629. BS R67637. BS R67643. BS R67644. BS R41742. BS R64555. BS R41743. BS R41744. BS R67686. BS R67687. BS R67688. BS R67670. BS R67671. BS R67672. BS R67673. BS R67665. BS R67666. BS R67689. BS R67740. BS R67742. BS R33290. BS R68250. BS R68251. BS R66039. BS R66043. XX DR TRANSPATH: MO000017951. DR UniProtKB: Q02248; XX RN [1]; RE0006108. RX PUBMED: 8757136. RA Behrens J., von Kries J. P., Kuehl M., Bruhn L., Wedlich D., Grosschedl R., Birchmeier W. RT Functional interaction of beta-catenin with the transcription factor LEF -1 RL Nature 382:638-642 (1996). RN [2]; RE0014088. RX PUBMED: 9488439. RA Korinek V., Barker N., Willert K., Molenaar M., Roose J., Wagenaar G., Markman M., Lamers W., Destree O., Clevers H. RT Two members of the Tcf family implicated in Wnt/beta-Catenin signaling during embryogenesis in the mouse RL Mol. Cell. Biol. 18:1248-1256 (1998). RN [3]; RE0014125. RX PUBMED: 7806582. RA Hulsken J., Birchmeier W., Behrens J. RT E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton RL J. Cell Biol. 127:2061-2069 (1994). RN [4]; RE0014192. RX PUBMED: 9298899. RA Huber A. H., Nelson W. J., Weis W. I. RT Three-dimensional structure of the armadillo repeat region of beta-catenin RL Cell 90:871-882 (1997). RN [5]; RE0014336. RX PUBMED: 9671490. RA Hsu S.-C., Galceran J., Grosschedl R. RT Modulation of transcriptional regulation by LEF-1 in response to Wnt-1 signaling and association with beta-catenin RL Mol. Cell. Biol. 18:4807-4818 (1998). RN [6]; RE0014350. RX PUBMED: 7907279. RA Peifer M., Berg S., Reynolds A. B. RT A repeating amino acid motif shared by proteins with diverse cellular roles RL Cell 76:789-791 (1994). RN [7]; RE0018458. RX PUBMED: 10477752. RA Espada J., Perez-Moreno M., Braga V. M., Rodriguez-Viciana P., Cano A. RT H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes RL J. Cell Biol. 146:967-980 (1999). RN [8]; RE0018717. RX PUBMED: 10772923. RA Dobrosotskaya I. Y., James G. L. RT MAGI-1 interacts with beta-catenin and is associated with cell-cell adhesion structures RL Biochem. Biophys. Res. Commun. 270:903-909 (2000). RN [9]; RE0021544. RX PUBMED: 1509266. RA Butz S., Stappert J., Weissig H., Kemler R. RT Plakoglobin and beta-catenin: distinct but closely related RL Science 257:1142-1144 (1992). RN [10]; RE0021926. RX PUBMED: 10473551. RA Fukata M., Kuroda S., Nakagawa M., Kawajiri A., Itoh N., Shoji I., Matsuura Y., Yonehara S., Fujisawa H., Kikuchi A., Kaibuchi K. RT Cdc42 and Rac1 regulate the interaction of IQGAP1 with beta-catenin RL J. Biol. Chem. 274:26044-26050 (1999). RN [11]; RE0025665. RX PUBMED: 11826105. RA Nishimura W., Yao I., Iida J., Tanaka N., Hata Y. RT Interaction of synaptic scaffolding molecule and Beta -catenin. RL J. Neurosci. 22:757-65 (2002). RN [12]; RE0030782. RX PUBMED: 12151522. RA Coussen F., Normand E., Marchal C., Costet P., Choquet D., Lambert M., Mege R. M., Mulle C. RT Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes. RL J. Neurosci. 22:6426-36 (2002). RN [13]; RE0039085. RX PUBMED: 12917489. RA Niemann C., Unden A. B., Lyle S., Zouboulis ChC, Toftgard R., Watt F. M. RT Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis RL Proc. Natl. Acad. Sci. USA 100:11873-11880 (2003). RN [14]; RE0040278. RX PUBMED: 12063257. RA Liu T., Lee Y. N., Malbon C. C., Wang H. Y. RT Activation of the beta-catenin/Lef-Tcf pathway is obligate for formation of primitive endoderm by mouse F9 totipotent teratocarcinoma cells in response to retinoic acid RL J. Biol. Chem. 277:30887-91 (2002). RN [15]; RE0043567. RX PUBMED: 15140894. RA Ooshio T., Irie K., Morimoto K., Fukuhara A., Imai T., Takai Y. RT Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells RL J. Biol. Chem. 279:31365-73 (2004). RN [16]; RE0047049. RX PUBMED: 14687547. RA Gold D. A., Baek S. H., Schork N. J., Rose D. W., Larsen D. D., Sachs B. D., Rosenfeld M. G., Hamilton B. A. RT RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways RL Neuron 40:1119-31 (2003). RN [17]; RE0047219. RX PUBMED: 15604245. RA Verras M., Brown J., Li X., Nusse R., Sun Z. RT Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells RL Cancer Res. 64:8860-6 (2004). RN [18]; RE0048184. RX PUBMED: 15576399. RA Hu M. C., Rosenblum N. D. RT Smad1, beta-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription. RL Development 132:215-225 (2005). RN [19]; RE0048262. RX PUBMED: 16210377. RA Singh R., Artaza J. N., Taylor W. E., Braga M., Yuan X., Gonzalez-Cadavid N. F., Bhasin S. RT Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. RL Endocrinology 147:141-154 (2006). RN [20]; RE0048818. RX PUBMED: 16717102. RA Abramova M. V., Pospelova T. V., Nikulenkov F. P., Hollander C. M., Fornace AJ J. r., Pospelov V. A. RT G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin. RL J. Biol. Chem. 281:21040-21051 (2006). RN [21]; RE0049452. RX PUBMED: 17191119. RA Gregorc U., Ivanova S., Thomas M., Guccione E., Glaunsinger B., Javier R., Turk V., Banks L., Turk B. RT Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis. RL Apoptosis 12:343-354 (2007). RN [22]; RE0049864. RX PUBMED: 10862698. RA Husi H., Ward M. A., Choudhary J. S., Blackstock W. P., Grant S. G. RT Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. RL Nat. Neurosci. 3:661-669 (2000). RN [23]; RE0050087. RX PUBMED: 16094404. RA Henderson C. J., Aleo E., Fontanini A., Maestro R., Paroni G., Brancolini C. RT Caspase activation and apoptosis in response to proteasome inhibitors. RL Cell Death Differ. 12:1240-1254 (2005). RN [24]; RE0054638. RX PUBMED: 18593713. RA Tang Y., Liu Z., Zhao L., Clemens T. L., Cao X. RT Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion. RL J. Biol. Chem. 283:23956-23963 (2008). RN [25]; RE0064443. RX PUBMED: 17244763. RA Salisbury T. B., Binder A. K., Grammer J. C., Nilson J. H. RT Maximal activity of the luteinizing hormone beta-subunit gene requires beta-catenin. RL Mol. Endocrinol. 21:963-971 (2007). RN [26]; RE0064539. RX PUBMED: 18451303. RA Thornton T. M., Pedraza-Alva G., Deng B., Wood C. D., Aronshtam A., Clements J. L., Sabio G., Davis R. J., Matthews D. E., Doble B., Rincon M. RT Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. RL Science 320:667-670 (2008). RN [27]; RE0064592. RX PUBMED: 15328362. RA Paling N. R., Wheadon H., Bone H. K., Welham M. J. RT Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. RL J. Biol. Chem. 279:48063-48070 (2004). RN [28]; RE0065565. RX PUBMED: 19131506. RA Salisbury T. B., Binder A. K., Grammer J. C., Nilson J. H. RT GnRH-regulated expression of Jun and JUN target genes in gonadotropes requires a functional interaction between TCF/LEF family members and beta-catenin. RL Mol. Endocrinol. 23:402-411 (2009). RN [29]; RE0066547. RX PUBMED: 14722104. RA Swiatek W., Tsai I. C., Klimowski L., Pepler A., Barnette J., Yost H. J., Virshup D. M. RT Regulation of casein kinase I epsilon activity by Wnt signaling. RL J. Biol. Chem. 279:13011-13017 (2004). RN [30]; RE0066997. RX PUBMED: 19619491. RA Zhang Y., Tomann P., Andl T., Gallant N. M., Huelsken J., Jerchow B., Birchmeier W., Paus R., Piccolo S., Mikkola M. L., Morrisey E. E., Overbeek P. A., Scheidereit C., Millar S. E., Schmidt-Ullrich R. RT Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. RL Dev. Cell 17:49-61 (2009). RN [31]; RE0067022. RX PUBMED: 16054035. RA Mill P., Mo R., Hu M. C., Dagnino L., Rosenblum N. D., Hui C. C. RT Shh controls epithelial proliferation via independent pathways that converge on N-Myc. RL Dev. Cell 9:293-303 (2005). RN [32]; RE0070827. RX PUBMED: 19995909. RA Luo Z., Wijeweera A., Oh Y., Liou Y. C., Melamed P. RT Pin1 facilitates the phosphorylation-dependent ubiquitination of SF-1 to regulate gonadotropin beta-subunit gene transcription. RL Mol. Cell. Biol. 30:745-763 (2010). RN [33]; RE0071270. RX PUBMED: 9110993. RA Obama H., Ozawa M. RT Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin). RL J. Biol. Chem. 272:11017-11020 (1997). RN [34]; RE0071993. RX PUBMED: 21074722. RA Gladden A. B., Hebert A. M., Schneeberger E. E., McClatchey A. I. RT The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. RL Dev. Cell 19:727-739 (2010). XX //