AC T02450
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ID T02450
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DT 07.05.1998 (created); ewi.
DT 27.01.2016 (updated); ros.
CO Copyright (C), QIAGEN.
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FA GKLF
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SY epithelial zinc-finger protein; EZF; gut-enriched Krueppel-like factor; KLF4; Krueppel-like factor 4; ZIE.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006344 Klf4.
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CL C0001; CH; 2.3.1.2.4.
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SF mouse GKLF T02450 and human Sp1 T00759 physically interact with each other and form a heterodimer;
SF the competitive effect of GKLF on the binding of Sp1 to BTE appears to be further augmented by a direct physical interaction between the two proteins [5];
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CP (adult:) gastrointestinal tract [4].
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FF Treatment of the factor with KLF4 increased significantly in response to LPS stimulation [6];
FF activator [3];
FF very low levels during early embryogenesis (until E13), expression rises on E13 and peaks at E17 [4];
FF down-regulated during tumor formation [4];
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IN T02984 beta-catenin; mouse, Mus musculus.
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MX M01588 V$GKLF_02.
MX M07040 V$GKLF_Q3.
MX M07289 V$GKLF_Q3_01.
MX M01835 V$GKLF_Q4.
MX M07461 V$KLF_Q3.
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BS R05016.
BS R60356.
BS R60364.
BS R35472.
BS R35470.
BS R68502.
BS R23680.
BS R24212.
BS R69572.
BS R69574.
BS R69577.
BS R69579.
BS R69582.
BS R69584.
BS R69587.
BS R69620.
BS R69651.
BS R69652.
BS R69654.
BS R69655.
BS R69656.
BS R69658.
BS R69659.
BS R33108.
BS R31496.
BS R66897.
BS R28655.
BS R28657.
BS R28658.
BS R28659.
BS R28660.
BS R62402.
BS R62403.
BS R71626.
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DR TRANSPATH: MO000026433.
DR UniProtKB: Q60793;
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RN [1]; RE0006854.
RX PUBMED: 8702718.
RA Shields J. M., Christy R. J., Yang V. W.
RT Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest
RL J. Biol. Chem. 271:20009-20017 (1996).
RN [2]; RE0006856.
RX PUBMED: 8940147.
RA Garrett-Sinha L. A., Eberspaecher H., Seldin M. F., Crombrugghe B.
RT A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells
RL J. Biol. Chem. 271:31384-31390 (1996).
RN [3]; RE0006857.
RX PUBMED: 9443972.
RA Shields J. M., Yang V. W.
RT Identification of the DNA sequence that interacts with the gut-enriched Krueppel-like factor
RL Nucleic Acids Res. 26:796-802 (1998).
RN [4]; RE0006858.
RX PUBMED: 9428642.
RA Ton-That H., Kaestner K. H., Shields J. M., Mahatanankoon C. S., Yang V. W.
RT Expression of the gut-enriched Krueppel-like factor gene during development and intestinal tumorigenesis
RL FEBS Lett. 419:239-243 (1997).
RN [5]; RE0024733.
RX PUBMED: 9651398.
RA Zhang W., Shields J. M., Sogawa K., Fujii-Kuriyama Y., Yang V. W.
RT The gut-enriched Kruppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion.
RL J. Biol. Chem. 273:17917-17925 (1998).
RN [6]; RE0051861.
RX PUBMED: 17719562.
RA Liu J., Zhang H., Liu Y., Wang K., Feng Y., Liu M., Xiao X.
RT KLF4 regulates the expression of interleukin-10 in RAW264.7 macrophages.
RL Biochem. Biophys. Res. Commun. 362:575-581 (2007).
RN [7]; RE0068433.
RX PUBMED: 20946687.
RA Kaushik D. K., Gupta M., Das S., Basu A.
RT Kruppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation.
RL J. Neuroinflammation 7:68 (2010).
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