TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02450 XX ID T02450 XX DT 07.05.1998 (created); ewi. DT 27.01.2016 (updated); ros. CO Copyright (C), QIAGEN. XX FA GKLF XX SY epithelial zinc-finger protein; EZF; gut-enriched Krueppel-like factor; KLF4; Krueppel-like factor 4; ZIE. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G006344 Klf4. XX CL C0001; CH; XX SF mouse GKLF T02450 and human Sp1 T00759 physically interact with each other and form a heterodimer; SF the competitive effect of GKLF on the binding of Sp1 to BTE appears to be further augmented by a direct physical interaction between the two proteins [5]; XX CP (adult:) gastrointestinal tract [4]. XX FF Treatment of the factor with KLF4 increased significantly in response to LPS stimulation [6]; FF activator [3]; FF very low levels during early embryogenesis (until E13), expression rises on E13 and peaks at E17 [4]; FF down-regulated during tumor formation [4]; XX IN T02984 beta-catenin; mouse, Mus musculus. XX MX M01588 V$GKLF_02. MX M07040 V$GKLF_Q3. MX M07289 V$GKLF_Q3_01. MX M01835 V$GKLF_Q4. MX M07461 V$KLF_Q3. XX BS R05016. BS R60356. BS R60364. BS R35472. BS R35470. BS R68502. BS R23680. BS R24212. BS R69572. BS R69574. BS R69577. BS R69579. BS R69582. BS R69584. BS R69587. BS R69620. BS R69651. BS R69652. BS R69654. BS R69655. BS R69656. BS R69658. BS R69659. BS R33108. BS R31496. BS R66897. BS R28655. BS R28657. BS R28658. BS R28659. BS R28660. BS R62402. BS R62403. BS R71626. XX DR TRANSPATH: MO000026433. DR UniProtKB: Q60793; XX RN [1]; RE0006854. RX PUBMED: 8702718. RA Shields J. M., Christy R. J., Yang V. W. RT Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest RL J. Biol. Chem. 271:20009-20017 (1996). RN [2]; RE0006856. RX PUBMED: 8940147. RA Garrett-Sinha L. A., Eberspaecher H., Seldin M. F., Crombrugghe B. RT A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells RL J. Biol. Chem. 271:31384-31390 (1996). RN [3]; RE0006857. RX PUBMED: 9443972. RA Shields J. M., Yang V. W. RT Identification of the DNA sequence that interacts with the gut-enriched Krueppel-like factor RL Nucleic Acids Res. 26:796-802 (1998). RN [4]; RE0006858. RX PUBMED: 9428642. RA Ton-That H., Kaestner K. H., Shields J. M., Mahatanankoon C. S., Yang V. W. RT Expression of the gut-enriched Krueppel-like factor gene during development and intestinal tumorigenesis RL FEBS Lett. 419:239-243 (1997). RN [5]; RE0024733. RX PUBMED: 9651398. RA Zhang W., Shields J. M., Sogawa K., Fujii-Kuriyama Y., Yang V. W. RT The gut-enriched Kruppel-like factor suppresses the activity of the CYP1A1 promoter in an Sp1-dependent fashion. RL J. Biol. Chem. 273:17917-17925 (1998). RN [6]; RE0051861. RX PUBMED: 17719562. RA Liu J., Zhang H., Liu Y., Wang K., Feng Y., Liu M., Xiao X. RT KLF4 regulates the expression of interleukin-10 in RAW264.7 macrophages. RL Biochem. Biophys. Res. Commun. 362:575-581 (2007). RN [7]; RE0068433. RX PUBMED: 20946687. RA Kaushik D. K., Gupta M., Das S., Basu A. RT Kruppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation. RL J. Neuroinflammation 7:68 (2010). XX //