AC T02915
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ID T02915
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DT 26.01.2000 (created); sur.
DT 26.03.2008 (updated); grs.
CO Copyright (C), QIAGEN.
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FA TCF-4-isoform1
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SY T-cell factor 4; TCF-4; TCF-4 isoform 1; Tcf4; TCF7L2; transcription factor 7-like 2, T-cell specific, HMG-box.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014319 Tcf7l2.
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CL C0015; HMG.
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SZ 459 AA; 51.2 kDa (cDNA) (calc.).
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SQ MPQLNGGGGDDLGANDELISFKDEGEQEEKNSENSSAERDLADVKSSLVNESETNQDSSS
SQ DSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGS
SQ LSPTARTYLQMKWPLLDVQAGSLQSRQTLKDARSPSPAHIVSNKVPVVQHPHHVHPLTPL
SQ ITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQ
SQ QGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQES
SQ SQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQI
SQ LGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSE
SQ CFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCSL
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SC translated from EMBL #MMTCF4
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FT 8 53 
beta-Catenin interaction domain [2].
FT 326 396 
SM00398; hmgende2.
FT 327 400 
HMG domain [2].
FT 327 395 
PF00505; HMG (high mobility group) box.
FT 327 395 
PS50118; HMG_BOX_2.
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SF TCF-4-isoform1-isoform1 has multiple RNA splice variants with diverse sequences 3� to the HMG box [3];
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CP after day 10.5, di- and mesencephalon and intestinal epithelium during embryogenesis [2]; embryo: gut epithelium, brain: thalamus and roof of midbrain [3]; adult: widespread expression with high levels in liver and gastrointestinal tract [3] [2] [3].
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FF TCF-4-isoform1-isoform1 seems to have an important function in the development of the vertebrate gastrointestinal tract [3];
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IN T02984 beta-catenin; mouse, Mus musculus.
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MX M00671 V$TCF4_Q5.
MX M04633 V$TCF4_Q5_02.
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DR TRANSPATH: MO000026879.
DR EMBL: AJ223070;
DR UniProtKB: Q924A0-1;
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RN [1]; RE0014028.
RX PUBMED: 9784592.
RA Cho E. A., Dressler G. R.
RT TCF-4 binds beta-catenin and is expressed in distinct regions of the embryonic brain and limbs
RL Mech. Dev. 77:9-18 (1998).
RN [2]; RE0014088.
RX PUBMED: 9488439.
RA Korinek V., Barker N., Willert K., Molenaar M., Roose J., Wagenaar G., Markman M., Lamers W., Destree O., Clevers H.
RT Two members of the Tcf family implicated in Wnt/beta-Catenin signaling during embryogenesis in the mouse
RL Mol. Cell. Biol. 18:1248-1256 (1998).
RN [3]; RE0014557.
RX PUBMED: 9880534.
RA Lee Y. J., Swencki B., Shoichet S., Shivdasani R. A.
RT A possible role for the high mobility group box transcription factor Tcf-4 in vertebrate gut epithelial cell differentiation
RL J. Biol. Chem. 274:1566-1572 (1999).
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