AC T03489
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ID T03489
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DT 26.06.2000 (created); rio.
DT 05.08.2011 (updated); pos.
CO Copyright (C), QIAGEN.
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FA Crx
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SY cone rod homeobox protein.
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OS cattle, Bos taurus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; artiodactyla; ruminantia; pecora; bovidae
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GE G090970 CRX.
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CL C0006; homeo.
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SZ 299 AA; 32.3 kDa (cDNA) (calc.).
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SQ MMAYMNPGPHYSVNALALSGPSVDLMHPAVSYPSAPRKQRRERTTFTRSQLEELEALFAK
SQ TQYPDVYAREEVALKINLPESRVQVWFKNRRAKCRQQRQQQKQQQQPPGAQAKARPAKRK
SQ AGTSPRSSTDVCPDPLGISDSYSPPLPGPSGSPTTAVATVSIWSPASESPLPEAQRAGLV
SQ ASGPSLTSAPYAMTYAPASAFCSSPSAYGSPSSYFSGLDPYLSPMVPPLGGPALSPLSGP
SQ SVGPSLTQSPTSLSGQSYGTYSPVDSLEFKDPTGTWKFTYNPMDPLDYKDQSAWKFQIL
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SC translated from EMBL #AF154123
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FT 37 97 
PS50071; HOMEOBOX_2.
FT 39 95 
PS50552; PAX.
FT 39 101 
SM00389; HOX_1.
FT 40 96 
PF00046; Homeobox domain.
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SF 96% identity to murine Crx protein and 100% identity to murine Crx homeo domain [1];
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CP retina, retina pigment epithelium (RPE) [1].
CN brain, heart, liver, muscle, testis [1].
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IN T17380 FIZ1; cattle, Bos taurus.
IN T08326 Sp1; Mammalia.
IN T08327 Sp3; Mammalia.
IN T10071 sp4; human, Homo sapiens.
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MX M01436 V$CRX_02.
MX M00623 V$CRX_Q4.
MX M01712 V$CRX_Q4_01.
MX M07352 V$CRX_Q4_02.
MX M08892 V$CRX_Q6.
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BS R09104.
BS R09106.
BS R30067.
BS R30069.
BS R30070.
BS R30129.
BS R30128.
BS R33353.
BS R33354.
BS R30516.
BS R31003.
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DR TRANSPATH: MO000027424.
DR EMBL: AF154123;
DR UniProtKB: Q9XSK0;
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RN [1]; RE0014673.
RX PUBMED: 9390516.
RA Chen S., Wang Q. L., Nie Z., Sun H., Lennon G., Copeland N. G., Gilbert D. J., Jenkins N. A., Zack D. J.
RT Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes
RL Neuron 19:1017-1030 (1997).
RN [2]; RE0050763.
RX PUBMED: 11943774.
RA Lerner L. E., Gribanova Y. E., Whitaker L., Knox B. E., Farber D. B.
RT The rod cGMP-phosphodiesterase beta-subunit promoter is a specific target for Sp4 and is not activated by other Sp proteins or CRX.
RL J. Biol. Chem. 277:25877-25883 (2002).
RN [3]; RE0060035.
RX PUBMED: 15781457.
RA Lerner L. E., Peng G. H., Gribanova Y. E., Chen S., Farber D. B.
RT Sp4 is expressed in retinal neurons, activates transcription of photoreceptor-specific genes, and synergizes with Crx.
RL J. Biol. Chem. 280:20642-20650 (2005).
RN [4]; RE0065614.
RX PUBMED: 18854042.
RA Mali R. S., Peng G. H., Zhang X., Dang L., Chen S., Mitton K. P.
RT FIZ1 is part of the regulatory protein complex on active photoreceptor-specific gene promoters in vivo.
RL BMC Mol. Biol. 9:87 (2008).
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