AC T08612
XX
ID T08612
XX
DT 10.03.2005 (created); nvo.
DT 10.07.2015 (updated); smt.
CO Copyright (C), QIAGEN.
XX
FA HNF-4alpha
XX
SY Hepatocyte Nuclear Factor 4.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T15601 AR; Mammalia.
IN T10818 arnt; Mammalia.
IN T15118 CBP; Mammalia.
IN T14067 FOXO1A; Mammalia.
IN T10060 HNF-1alpha; Mammalia.
IN T16651 HNF-4gamma; Mammalia.
IN T08255 PGC-1-isoform1; mouse, Mus musculus.
IN T28267 PGC-1; Mammalia.
IN T14480 Prox-1; Mammalia.
IN T23084 SHP; Mammalia.
IN T09538 Smad3; Mammalia.
IN T13998 Smad4; Mammalia.
IN T08326 Sp1; Mammalia.
IN T21552 SRC-1; Mammalia.
IN T17428 TFIIB; Mammalia.
XX
MX M00158 V$COUP_01.
MX M00762 V$DR1_Q3.
MX M00638 V$HNF4ALPHA_Q6.
MX M07321 V$HNF4A_Q3.
MX M02016 V$HNF4A_Q6_01.
MX M00764 V$HNF4DR1_Q3.
MX M00134 V$HNF4_01.
MX M00411 V$HNF4_01_B.
MX M00967 V$HNF4_Q6.
MX M01031 V$HNF4_Q6_01.
MX M01032 V$HNF4_Q6_02.
MX M01033 V$HNF4_Q6_03.
MX M03828 V$HNF4_Q6_04.
XX
BS R25058.
BS R00116.
BS R26637.
BS R26635.
BS R12993.
BS R21453.
BS R60270.
BS R02657.
BS R13058.
BS R31228.
BS R32852.
BS R31213.
BS R15898.
BS R20731.
BS R15916.
BS R39504.
BS R68618.
BS R68619.
BS R27979.
BS R27980.
BS R20743.
BS R32881.
BS R22735.
BS R39670.
BS R39671.
BS R31235.
BS R31248.
BS R18936.
BS R56711.
BS R42344.
BS R66637.
BS R73706.
BS R26100.
BS R31014.
BS R42303.
BS R03034.
BS R56753.
BS R13067.
BS R23474.
BS R26418.
BS R26422.
BS R26423.
BS R26424.
BS R73884.
BS R13035.
BS R31015.
XX
DR TRANSPATH: MO000047902.
DR TRANSCOMPEL: C00018.
DR TRANSCOMPEL: C00041.
DR TRANSCOMPEL: C00065.
DR TRANSCOMPEL: C00123.
DR TRANSCOMPEL: C00279.
DR TRANSCOMPEL: C00291.
DR TRANSCOMPEL: C00525.
DR TRANSCOMPEL: C00643.
DR TRANSCOMPEL: C00644.
XX
RN [1]; RE0006836.
RX PUBMED: 8657158.
RA Malik S., Karathanasis S. K.
RT TFIIB-directed transcriptional activation by the Orphan nuclear receptor hepatocyte nuclear factor 4
RL Mol. Cell. Biol. 16:1824-1831 (1996).
RN [2]; RE0013339.
RX PUBMED: 9812974.
RA Wang Jen.-Chywan, Stafford John. M., Granner Daryl. K.
RT SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4
RL J. Biol. Chem. 273:30847-30850 (1998).
RN [3]; RE0015109.
RX PUBMED: 10866048.
RA Ilag L. L., Tabaei B. P., Herman W. H., Zawacki C. M., D'Souza E., Bell G. I., Fajans S. S.
RT Reduced pancreatic polypeptide response to hypoglycemia and amylin response to arginine in subjects with a mutation in the HNF-4alpha/MODY1 gene
RL Diabetes 49:961-968 (2000).
RN [4]; RE0018051.
RX PUBMED: 11839757.
RA Pastier D., Lacorte J.-M., Chambaz J., Cardot P., Ribeiro A.
RT Two initiator-like elements are required for the combined activation of the human apolipoprotein C-III promoter by upstream stimulatory factor and hepatic nuclear factor-4.
RL J. Biol. Chem. 277:15199-15206 (2002).
RN [5]; RE0018055.
RX PUBMED: 12220531.
RA Ozeki T., Takahashi Y., Nakayama K., Kamataki T.
RT Hepatocyte nuclear factor (HNF)-4alpha/gamma, HNF-1alpha, and vHNF-1 regulate the cell-specific expression of the human dihydrodiol dehydrogenase (DD)4/AKR1C4 gene.
RL Arch. Biochem. Biophys. 405:185 (2002).
RN [6]; RE0018077.
RX PUBMED: 10674400.
RA Lahuna O., Rastegar M., Maiter D., Thissen J.-P., Lemaigre F. P., Rousseau G. G.
RT Involvement of STAT5 (signal transducer and activator of transcription 5) and HNF-4 (hepatocyte nuclear factor 4) in the transcriptional control of the hnf6 gene by growth hormone.
RL Mol. Endocrinol. 14:285-294 (2000).
RN [7]; RE0021482.
RX PUBMED: 12097158.
RA Tsuchiya T., Kominato Y., Ueda M.
RT Human Hypoxic Signal Transduction through a Signature Motif in Hepatocyte Nuclear Factor 4
RL J. Biochem. 132:37-44 (2002).
RN [8]; RE0023200.
RX PUBMED: 12631740.
RA Chou W. C., Prokova V., Shiraishi K., Valcourt U., Moustakas A., Hadzopoulou-Cladaras M., Zannis V. I., Kardassis D.
RT Mechanism of a Transcriptional Cross Talk between Transforming Growth Factor-beta-regulated Smad3 and Smad4 Proteins and Orphan Nuclear Receptor Hepatocyte Nuclear Factor-4.
RL Mol. Biol. Cell 14:1279-1294 (2003).
RN [9]; RE0023998.
RX PUBMED: 14988562.
RA Odom D. T., Zizlsperger N., Gordon D. B., Bell G. W., Rinaldi N. J., Murray H. L., Volkert T. L., Schreiber J., Rolfe P. A., Gifford D. K., Fraenkel E., Bell G. I., Young R. A.
RT Control of pancreas and liver gene expression by HNF transcription factors.
RL Science 303:1378-1381 (2004).
RN [10]; RE0025099.
RX PUBMED: 7794915.
RA Ibeanu G. C., Goldstein J. A.
RT Transcriptional regulation of human CYP2C genes: functional comparison of CYP2C9 and CYP2C18 promoter regions.
RL Biochemistry 34:8028-8036 (1995).
RN [11]; RE0029557.
RX PUBMED: 11865043.
RA Ruse M. D. Jr, Privalsky M. L., Sladek F. M.
RT Competitive cofactor recruitment by orphan receptor hepatocyte nuclear factor 4alpha1: modulation by the F domain.
RL Mol. Cell. Biol. 22:1626-38 (2002).
RN [12]; RE0031578.
RX PUBMED: 11802721.
RA Kardassis D., Falvey E., Tsantili P., Hadzopoulou-Cladaras M., Zannis V.
RT Direct physical interactions between HNF-4 and Sp1 mediate synergistic transactivation of the apolipoprotein CIII promoter.
RL Biochemistry 41:1217-28 (2002).
RN [13]; RE0031583.
RX PUBMED: 9233568.
RA Morgan G. E., Rowley G., Green P. M., Chisholm M., Giannelli F., Brownlee G. G.
RT Further evidence for the importance of an androgen response element in the factor IX promoter.
RL Br. J. Haematol. 98:79-85 (1997).
RN [14]; RE0031601.
RX PUBMED: 14722127.
RA Yamamoto T., Shimano H., Nakagawa Y., Ide T., Yahagi N., Matsuzaka T., Nakakuki M., Takahashi A., Suzuki H., Sone H., Toyoshima H., Sato R., Yamada N.
RT SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes.
RL J. Biol. Chem. 279:12027-35 (2004).
RN [15]; RE0034840.
RX PUBMED: 15322103.
RA Bhalla S., Ozalp C., Fang S., Xiang L., Kemper J. K.
RT Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.
RL J. Biol. Chem. 279:45139-47 (2004).
RN [16]; RE0036578.
RX PUBMED: 12594208.
RA Ning Q., Lakatoo S., Liu M., Yang W., Wang Z., Phillips M. J., Levy G. A.
RT Induction of prothrombinase fgl2 by the nucleocapsid protein of virulent mouse hepatitis virus is dependent on host hepatic nuclear factor-4 alpha
RL J. Biol. Chem. 278:15541-9 (2003).
RN [17]; RE0037503.
RX PUBMED: 12101254.
RA Malik S., Wallberg A. E., Kang Y. K., Roeder R. G.
RT TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4
RL Mol. Cell. Biol. 22:5626-37 (2002).
RN [18]; RE0037818.
RX PUBMED: 14583614.
RA Inoue Y., Yu A. M., Inoue J., Gonzalez F. J.
RT Hepatocyte nuclear factor 4alpha is a central regulator of bile acid conjugation
RL J. Biol. Chem. 279:2480-9 (2004).
RN [19]; RE0038049.
RX PUBMED: 11916906.
RA Iwahashi H., Yamagata K., Yoshiuchi I., Terasaki J., Yang Q., Fukui K., Ihara A., Zhu Q., Asakura T., Cao Y., Imagawa A., Namba M., Hanafusa T., Miyagawa J., Matsuzawa Y.
RT Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha
RL Diabetes 51:910-4 (2002).
RN [20]; RE0038317.
RX PUBMED: 10594021.
RA Lee Y. K., Dell H., Dowhan D. H., Hadzopoulou-Cladaras M., Moore D. D.
RT The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression
RL Mol. Cell. Biol. 20:187-95 (2000).
RN [21]; RE0038389.
RX PUBMED: 15141028.
RA Eeckhoute J., Formstecher P., Laine B.
RT Hepatocyte nuclear factor 4alpha enhances the hepatocyte nuclear factor 1alpha-mediated activation of transcription
RL Nucleic Acids Res. 32:2586-93 (2004).
RN [22]; RE0038403.
RX PUBMED: 15107844.
RA Koo S. H., Satoh H., Herzig S., Lee C. H., Hedrick S., Kulkarni R., Evans R. M., Olefsky J., Montminy M.
RT PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3
RL Nat. Med. 10:530-4 (2004).
RN [23]; RE0038411.
RX PUBMED: 10085149.
RA Dell H., Hadzopoulou-Cladaras M.
RT CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression
RL J. Biol. Chem. 274:9013-21 (1999).
RN [24]; RE0038462.
RX PUBMED: 12519792.
RA Hirota K., Daitoku H., Matsuzaki H., Araya N., Yamagata K., Asada S., Sugaya T., Fukamizu A.
RT Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor
RL J. Biol. Chem. 278:13056-60 (2003).
RN [25]; RE0038475.
RX PUBMED: 11723251.
RA Luo Z., Hines R. N.
RT Regulation of flavin-containing monooxygenase 1 expression by ying yang 1 and hepatic nuclear factors 1 and 4
RL Mol. Pharmacol. 60:1421-30 (2001).
RN [26]; RE0038476.
RX PUBMED: 12089346.
RA Maeda Y., Rachez C., Hawel L. 3rd, Byus C. V., Freedman L. P., Sladek F. M.
RT Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205
RL Mol. Endocrinol. 16:1502-10 (2002).
RN [27]; RE0038570.
RX PUBMED: 11277940.
RA Roy N., Guruprasad M. R., Kondaiah P., Mann E. A., Giannella R. A., Visweswariah S. S.
RT Protein kinase C regulates transcription of the human guanylate cyclase C gene
RL Eur. J. Biochem. 268:2160-71 (2001).
RN [28]; RE0038571.
RX PUBMED: 12855700.
RA Misawa K., Horiba T., Arimura N., Hirano Y., Inoue J., Emoto N., Shimano H., Shimizu M., Sato R.
RT Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes
RL J. Biol. Chem. 278:36176-82 (2003).
RN [29]; RE0041561.
RX PUBMED: 11723233.
RA Corchero J., Granvil C. P., Akiyama T. E., Hayhurst G. P., Pimprale S., Feigenbaum L., Idle J. R., Gonzalez F. J.
RT The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse
RL Mol. Pharmacol. 60:1260-7 (2001).
RN [30]; RE0051082.
RX PUBMED: 17895379.
RA Sanyal S., Bavner A., Haroniti A., Nilsson L. M., Lundasen T., Rehnmark S., Witt M. R., Einarsson C., Talianidis I., Gustafsson J. A., Treuter E.
RT Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis.
RL Proc. Natl. Acad. Sci. USA 104:15665-15670 (2007).
RN [31]; RE0052227.
RX PUBMED: 11733490.
RA Lin J., Puigserver P., Donovan J., Tarr P., Spiegelman B. M.
RT Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.
RL J. Biol. Chem. 277:1645-1648 (2002).
RN [32]; RE0052255.
RX PUBMED: 12915406.
RA Massillon D., Arinze I. J., Xu C., Bone F.
RT Regulation of glucose-6-phosphatase gene expression in cultured hepatocytes and H4IIE cells by short-chain fatty acids: role of hepatic nuclear factor-4alpha.
RL J. Biol. Chem. 278:40694-40701 (2003).
RN [33]; RE0052650.
RX PUBMED: 16825189.
RA Ding X., Lichti K., Kim I., Gonzalez F. J., Staudinger J. L.
RT Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha.
RL J. Biol. Chem. 281:26540-26551 (2006).
RN [34]; RE0053294.
RX PUBMED: 15826954.
RA Iordanidou P., Aggelidou E., Demetriades C., Hadzopoulou-Cladaras M.
RT Distinct amino acid residues may be involved in coactivator and ligand interactions in hepatocyte nuclear factor-4alpha.
RL J. Biol. Chem. 280:21810-21819 (2005).
RN [35]; RE0053638.
RX PUBMED: 16488887.
RA Song K. H., Li T., Chiang J. Y.
RT A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene.
RL J. Biol. Chem. 281:10081-10088 (2006).
RN [36]; RE0066471.
RX PUBMED: 18513187.
RA Guo D., Dong L. Y., Wu Y., Yang L., An W.
RT Down-regulation of hepatic nuclear factor 4alpha on expression of human hepatic stimulator substance via its action on the proximal promoter in HepG2 cells.
RL Biochem. J. 415:111-121 (2008).
RN [37]; RE0068245.
RX PUBMED: 18765665.
RA Ungaro P., Teperino R., Mirra P., Cassese A., Fiory F., Perruolo G., Miele C., Laakso M., Formisano P., Beguinot F.
RT Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II.
RL J. Biol. Chem. 283:30970-30979 (2008).
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