AC T08255
XX
ID T08255
XX
DT 09.11.2005 (created); oke.
DT 22.04.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA PGC-1-isoform1
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SY peroxisome proliferator activated receptor gamma coactivator 1 alpha; peroxisome-proliferator-activated receptor gamma, co-activator 1; PGC-1; PGC-1 alpha; PGC1; PPAR gamma coactivator-1 alpha; PPAR-gamma co-activator 1; PPARGC-1 alpha; PPARGC1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004833 Ppargc1a.
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SZ 797 AA; 90.6 kDa (cDNA) (calc.).
XX
SQ MAWDMCSQDSVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQS
SQ EIISNQYNNEPANIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGAVTTDNE
SQ ASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHAANHTHRIRTNPA
SQ IVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCASKKK
SQ SHTQPQSQHAQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPP
SQ HKANQDNPFKASPKLKPSCKTVVPPPTKRARYSECSGTQGSHSTKKGPEQSELYAQLSKS
SQ SGLSRGHEERKTKRPSLRLFGDHDYCQSLNSKTDILINISQELQDSRQLDFKDASCDWQG
SQ HICSSTDSGQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPCQAVFDDKSDKT
SQ SELRDGDFSNEQFSKLPVFINSGLAMDGLFDDSEDESDKLSYPWDGTQPYSLFDVSPSCS
SQ SFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCY
SQ YYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEAYEHERLKRDEYRKEHEKRESER
SQ AKQRERQKQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFIT
SQ YRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDTNSDDFDPASTKSKYD
SQ SLDFDSLLKEAQRSLRR
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SC translated from EMBL #AF049330
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FT 142 146 
LXXLL sequence is required for interactions with ERalpha, PPARalpha, HNF-4alpha [1].
FT 144 678 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 676 752 
PS50102; RRM.
FT 677 746 
SM00360; rrm1_1.
FT 678 744 
PF00076; RNA recognition motif. (a.k.a. RRM, RBD, or.
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IN T08910 Bcl-3; human, Homo sapiens.
IN T33929 DRIP205-isoform1; human, Homo sapiens.
IN T14760 ERR1; Mammalia.
IN T08612 HNF-4alpha; Mammalia.
IN T23091 p300; Mammalia.
IN T09963 PPARgamma; Mammalia.
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DR TRANSPATH: MO000056520.
DR EMBL: AF049330;
DR UniProtKB: O70343;
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RN [1]; RE0018079.
RX PUBMED: 11557972.
RA Yoon J. C., Puigserver P., Chen G., Donovan J., Wu Z., Rhee J., Adelmant G., Stafford J., Kahn C. R., Granner D. K., Newgard C. B., Spiegelman B. M.
RT Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
RL Nature 413:131-138 (2001).
RN [2]; RE0030488.
RX PUBMED: 12507421.
RA Picard F., Gehin M., Annicotte J., Rocchi S., Champy M. F., O'Malley B. W., Chambon P., Auwerx J.
RT SRC-1 and TIF2 control energy balance between white and brown adipose tissues.
RL Cell 111:931-41 (2002).
RN [3]; RE0030588.
RX PUBMED: 14636573.
RA Wallberg A. E., Yamamura S., Malik S., Spiegelman B. M., Roeder R. G.
RT Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.
RL Mol. Cell 12:1137-49 (2003).
RN [4]; RE0051163.
RX PUBMED: 15329387.
RA Savkur R. S., Thomas J. S., Bramlett K. S., Gao Y., Michael L. F., Burris T. P.
RT Ligand-dependent coactivation of the human bile acid receptor FXR by the peroxisome proliferator-activated receptor gamma coactivator-1alpha.
RL J. Pharmacol. Exp. Ther. 312:170-178 (2005).
RN [5]; RE0065191.
RX PUBMED: 17609368.
RA Jager S., Handschin C., St-Pierre J., Spiegelman B. M.
RT AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.
RL Proc. Natl. Acad. Sci. USA 104:12017-12022 (2007).
RN [6]; RE0066887.
RX PUBMED: 20404331.
RA Brault J. J., Jespersen J. G., Goldberg A. L.
RT PGC-1{alpha} or PGC-1{beta} (peroxisome proliferator-activated receptor {gamma} coactivator 1{alpha} or 1{beta}) overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy.
RL J. Biol. Chem. 285:19460-19471 (2010).
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