AC T09963
XX
ID T09963
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DT 10.03.2005 (created); nvo.
DT 17.05.2016 (updated); ros.
CO Copyright (C), QIAGEN.
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FA PPARgamma
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SY peroxisome proliferator-activated receptor gamma.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T15118 CBP; Mammalia.
IN T09447 JunD; Mammalia.
IN T04687 NCOR1; human, Homo sapiens.
IN T10399 NF-kappaB1-p50; Mammalia.
IN T23091 p300; Mammalia.
IN T08255 PGC-1-isoform1; mouse, Mus musculus.
IN T10397 RelA-p65; Mammalia.
IN T09964 RXR-alpha; Mammalia.
IN T23084 SHP; Mammalia.
IN T09538 Smad3; Mammalia.
IN T04689 SMRT; human, Homo sapiens.
IN T21552 SRC-1; Mammalia.
IN T16578 TGIF; Mammalia.
XX
MX M00763 V$PPARDR1_Q2.
MX M00512 V$PPARG_01.
MX M00515 V$PPARG_02.
MX M00528 V$PPARG_03.
MX M01270 V$PPARG_Q6.
XX
BS R07672.
BS R23756.
BS R35224.
BS R27359.
BS R56139.
BS R27357.
XX
DR TRANSPATH: MO000047193.
XX
RN [1]; RE0018030.
RX PUBMED: 10098492.
RA Robinson C. E., Wu X., Nawaz Z., Onate S. A., Gimble J. M.
RT A corepressor and chicken ovalbumin upstream promoter transcriptional factor proteins modulate peroxisome proliferator-activated receptor-gamma2/retinoid X receptor alpha-activated transcription from the murine lipoprotein lipase promoter.
RL Endocrinology 140:1586-1593 (1999).
RN [2]; RE0018197.
RX PUBMED: 10075656.
RA Gelman L., Zhou G., Fajas L., Raspe E., Fruchart J. C., Auwerx J.
RT p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively.
RL J. Biol. Chem. 274:7681-7688 (1999).
RN [3]; RE0022545.
RX PUBMED: 9843961.
RA Ribon V., Johnson J. H., Camp H. S., Saltiel A. R.
RT Thiazolidinediones and insulin resistance: peroxisome proliferatoractivated receptor gamma activation stimulates expression of the CAP gene.
RL Proc. Natl. Acad. Sci. USA 95:14751-14756 (1998).
RN [4]; RE0027683.
RX PUBMED: 10517671.
RA Monden T., Kishi M., Hosoya T., Satoh T., Wondisford F. E., Hollenberg A. N., Yamada M., Mori M.
RT p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers.
RL Mol. Endocrinol. 13:1695-703 (1999).
RN [5]; RE0029603.
RX PUBMED: 11971969.
RA Shao W., Halachmi S., Brown M.
RT ERAP140, a conserved tissue-specific nuclear receptor coactivator.
RL Mol. Cell. Biol. 22:3358-72 (2002).
RN [6]; RE0030318.
RX PUBMED: 12832613.
RA Patti M. E., Butte A. J., Crunkhorn S., Cusi K., Berria R., Kashyap S., Miyazaki Y., Kohane I., Costello M., Saccone R., Landaker E. J., Goldfine A. B., Mun E., DeFronzo R., Finlayson J., Kahn C. R., Mandarino L. J.
RT Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.
RL Proc. Natl. Acad. Sci. USA 100:8466-71 (2003).
RN [7]; RE0030488.
RX PUBMED: 12507421.
RA Picard F., Gehin M., Annicotte J., Rocchi S., Champy M. F., O'Malley B. W., Chambon P., Auwerx J.
RT SRC-1 and TIF2 control energy balance between white and brown adipose tissues.
RL Cell 111:931-41 (2002).
RN [8]; RE0030588.
RX PUBMED: 14636573.
RA Wallberg A. E., Yamamura S., Malik S., Spiegelman B. M., Roeder R. G.
RT Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.
RL Mol. Cell 12:1137-49 (2003).
RN [9]; RE0031507.
RX PUBMED: 15023995.
RA Cheng S., Afif H., Martel-Pelletier J., Pelletier J. P., Li X., Farrajota K., Lavigne M., Fahmi H.
RT Activation of peroxisome proliferator-activated receptor gamma inhibits interleukin-1beta-induced membrane-associated prostaglandin E2 synthase-1 expression in human synovial fibroblasts by interfering with Egr-1.
RL J. Biol. Chem. 279:22057-65 (2004).
RN [10]; RE0031870.
RX PUBMED: 10868955.
RA Maggi L. B. Jr, Sadeghi H., Weigand C., Scarim A. L., Heitmeier M. R., Corbett J. A.
RT Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression.
RL Diabetes 49:346-55 (2000).
RN [11]; RE0032617.
RX PUBMED: 14975242.
RA Wang L. H., Yang X. Y., Zhang X., Huang J., Hou J., Li J., Xiong H., Mihalic K., Zhu H., Xiao W., Farrar W. L.
RT Transcriptional inactivation of STAT3 by PPARgamma suppresses IL-6-responsive multiple myeloma cells.
RL Immunity 20:205-18 (2004).
RN [12]; RE0033961.
RX PUBMED: 15130092.
RA Schachtrup C., Emmler T., Bleck B., Sandqvist A., Spener F.
RT Functional analysis of peroxisome-proliferator-responsive element motifs in genes of fatty acid-binding proteins.
RL Biochem. J. 382:239-45 (2004).
RN [13]; RE0037090.
RX PUBMED: 12694805.
RA Bruemmer D., Berger J. P., Liu J., Kintscher U., Wakino S., Fleck E., Moller D. E., Law R. E.
RT A non-thiazolidinedione partial peroxisome proliferator-activated receptor gamma ligand inhibits vascular smooth muscle cell growth
RL Eur. J. Pharmacol. 466:225-34 (2003).
RN [14]; RE0037650.
RX PUBMED: 12039952.
RA Qi C., Chang J., Zhu Y., Yeldandi A. V., Rao S. M., Zhu Y. J.
RT Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha
RL J. Biol. Chem. 277:28624-30 (2002).
RN [15]; RE0037852.
RX PUBMED: 11792840.
RA Ting H. J., Yeh S., Nishimura K., Chang C.
RT Supervillin associates with androgen receptor and modulates its transcriptional activity
RL Proc. Natl. Acad. Sci. USA 99:661-6 (2002).
RN [16]; RE0037994.
RX PUBMED: 12897377.
RA Heinlein C. A., Chang C.
RT Induction and repression of peroxisome proliferator-activated receptor alpha transcription by coregulator ARA70
RL Endocrine 21:139-46 (2003).
RN [17]; RE0038010.
RX PUBMED: 10347167.
RA Heinlein C. A., Ting H. J., Yeh S., Chang C.
RT Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma
RL J. Biol. Chem. 274:16147-52 (1999).
RN [18]; RE0038547.
RX PUBMED: 15157741.
RA Schaffler A., Ehling A., Neumann E., Herfarth H., Paul G., Tarner I., Gay S., Buechler C., Scholmerich J., Muller-Ladner U.
RT Role of specificity protein-1, PPARgamma, and pituitary protein transcription factor-1 in transcriptional regulation of the murine CORS-26 promoter
RL Biochim. Biophys. Acta 1678:150-6 (2004).
RN [19]; RE0038618.
RX PUBMED: 12763030.
RA Malerod L., Sporstol M., Juvet L. K., Mousavi A., Gjoen T., Berg T.
RT Hepatic scavenger receptor class B, type I is stimulated by peroxisome proliferator-activated receptor gamma and hepatocyte nuclear factor 4alpha
RL Biochem. Biophys. Res. Commun. 305:557-65 (2003).
RN [20]; RE0040282.
RX PUBMED: 11493644.
RA Spinella-Jaegle S., Rawadi G., Kawai S., Gallea S., Faucheu C., Mollat P., Courtois B., Bergaud B., Ramez V., Blanchet A. M., Adelmant G., Baron R., Roman-Roman S.
RT Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation
RL J. Cell Sci. 114:2085-94 (2001).
RN [21]; RE0040549.
RX PUBMED: 12954078.
RA Moldes M., Zuo Y., Morrison R. F., Silva D., Park B. H., Liu J., Farmer S. R.
RT Peroxisome-proliferator-activated receptor gamma suppresses Wnt/beta-catenin signalling during adipogenesis
RL Biochem. J. 376:607-13 (2003).
RN [22]; RE0040618.
RX PUBMED: 9325263.
RA Zhu Y., Qi C., Jain S., Rao M. S., Reddy J. K.
RT Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor
RL J. Biol. Chem. 272:25500-6 (1997).
RN [23]; RE0041144.
RX PUBMED: 12517954.
RA Shankaranarayanan P., Nigam S.
RT IL-4 induces apoptosis in A549 lung adenocarcinoma cells: evidence for the pivotal role of 15-hydroxyeicosatetraenoic acid binding to activated peroxisome proliferator-activated receptor gamma transcription factor
RL J. Immunol. 170:887-94 (2003).
RN [24]; RE0041195.
RX PUBMED: 12086932.
RA Tamori Y., Masugi J., Nishino N., Kasuga M.
RT Role of peroxisome proliferator-activated receptor-gamma in maintenance of the characteristics of mature 3T3-L1 adipocytes
RL Diabetes 51:2045-55 (2002).
RN [25]; RE0041882.
RX PUBMED: 10412038.
RA Lecka-Czernik B., Gubrij I., Moerman E. J., Kajkenova O., Lipschitz D. A., Manolagas S. C., Jilka R. L.
RT Inhibition of Osf2/Cbfa1 expression and terminal osteoblast differentiation by PPARgamma2
RL J. Cell. Biochem. 74:357-71 (1999).
RN [26]; RE0042716.
RX PUBMED: 12077340.
RA Tan N. S., Shaw N. S., Vinckenbosch N., Liu P., Yasmin R., Desvergne B., Wahli W., Noy N.
RT Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription
RL Mol. Cell. Biol. 22:5114-27 (2002).
RN [27]; RE0042762.
RX PUBMED: 11069900.
RA Hansen J. B., Zhang H., Rasmussen T. H., Petersen R. K., Flindt E. N., Kristiansen K.
RT Peroxisome proliferator-activated receptor delta (PPARdelta )-mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling
RL J. Biol. Chem. 276:3175-82 (2001).
RN [28]; RE0042827.
RX PUBMED: 14534304.
RA Worley J. R., Baugh M. D., Hughes D. A., Edwards D. R., Hogan A., Sampson M. J., Gavrilovic J.
RT Metalloproteinase expression in PMA-stimulated THP-1 cells. Effects of peroxisome proliferator-activated receptor-gamma (PPAR gamma) agonists and 9-cis-retinoic acid
RL J. Biol. Chem. 278:51340-6 (2003).
RN [29]; RE0042875.
RX PUBMED: 11696534.
RA Nishizawa H., Yamagata K., Shimomura I., Takahashi M., Kuriyama H., Kishida K., Hotta K., Nagaretani H., Maeda N., Matsuda M., Kihara S., Nakamura T., Nishigori H., Tomura H., Moore D. D., Takeda J., Funahashi T., Matsuzawa Y.
RT Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation
RL J. Biol. Chem. 277:1586-92 (2002).
RN [30]; RE0043080.
RX PUBMED: 11592060.
RA Gosset P., Charbonnier A. S., Delerive P., Fontaine J., Staels B., Pestel J., Tonnel A. B., Trottein F.
RT Peroxisome proliferator-activated receptor gamma activators affect the maturation of human monocyte-derived dendritic cells
RL Eur. J. Immunol. 31:2857-65 (2001).
RN [31]; RE0043640.
RX PUBMED: 10936484.
RA Kintscher U., Goetze S., Wakino S., Kim S., Nagpal S., Chandraratna R. A., Graf K., Fleck E., Hsueh W. A., Law R. E.
RT Peroxisome proliferator-activated receptor and retinoid X receptor ligands inhibit monocyte chemotactic protein-1-directed migration of monocytes
RL Eur. J. Pharmacol. 401:259-70 (2000).
RN [32]; RE0043687.
RX PUBMED: 14702344.
RA Hazra S., Xiong S., Wang J., Rippe R. A., Krishna V., Chatterjee K., Tsukamoto H.
RT Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells
RL J. Biol. Chem. 279:11392-401 (2004).
RN [33]; RE0043974.
RX PUBMED: 11283155.
RA Desreumaux P., Dubuquoy L., Nutten S., Peuchmaur M., Englaro W., Schoonjans K., Derijard B., Desvergne B., Wahli W., Chambon P., Leibowitz M. D., Colombel J. F., Auwerx J.
RT Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies
RL J. Exp. Med. 193:827-38 (2001).
RN [34]; RE0044408.
RX PUBMED: 12675915.
RA Heneka M. T., Gavrilyuk V., Landreth G. E., O'Banion M. K., Weinberg G., Feinstein D. L.
RT Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression
RL J. Neurochem 85:387-98 (2003).
RN [35]; RE0045092.
RX PUBMED: 12437985.
RA Song H., Shojima N., Sakoda H., Ogihara T., Fujishiro M., Katagiri H., Anai M., Onishi Y., Ono H., Inukai K., Fukushima Y., Kikuchi M., Shimano H., Yamada N., Oka Y., Asano T.
RT Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules
RL Biochem. Biophys. Res. Commun. 299:291-8 (2002).
RN [36]; RE0045362.
RX PUBMED: 12457461.
RA Fu M., Zhang J., Lin Y., Zhu X., Zhao L., Ahmad M., Ehrengruber M. U., Chen Y. E.
RT Early stimulation and late inhibition of peroxisome proliferator-activated receptor gamma (PPAR gamma) gene expression by transforming growth factor beta in human aortic smooth muscle cells: role of early growth-response factor-1 (Egr-1), activator protein 1 (AP1) and Smads
RL Biochem. J. 370:1019-25 (2003).
RN [37]; RE0045643.
RX PUBMED: 15123608.
RA Phan J., Peterfy M., Reue K.
RT Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro
RL J. Biol. Chem. 279:29558-64 (2004).
RN [38]; RE0046149.
RX PUBMED: 14750214.
RA Ignatenko N. A., Babbar N., Mehta D., Casero R. A. Jr, Gerner E. W.
RT Suppression of polyamine catabolism by activated Ki-ras in human colon cancer cells
RL Mol. Carcinog. 39:91-102 (2004).
RN [39]; RE0046247.
RX PUBMED: 15111325.
RA Varley C. L., Stahlschmidt J., Smith B., Stower M., Southgate J.
RT Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells
RL Am. J. Pathol. 164:1789-98 (2004).
RN [40]; RE0046404.
RX PUBMED: 15130516.
RA Asaki T., Konishi M., Miyake A., Kato S., Tomizawa M., Itoh N.
RT Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo
RL Mol. Cell. Endocrinol. 218:119-28 (2004).
RN [41]; RE0046727.
RX PUBMED: 14759512.
RA Shimada T., Koitabashi A., Fujii Y., Hashimoto T., Hosaka K., Tabei K., Namatame T., Yoneda M., Hiraishi H., Terano A.
RT PPARgamma mediates NSAIDs-induced upregulation of TFF2 expression in gastric epithelial cells
RL FEBS Lett. 558:33-8 (2004).
RN [42]; RE0048488.
RX PUBMED: 15691842.
RA Yu C., Markan K., Temple K. A., Deplewski D., Brady M. J., Cohen R. N.
RT The nuclear receptor corepressors NCoR and SMRT decrease peroxisome proliferator-activated receptor gamma transcriptional activity and repress 3T3-L1 adipogenesis.
RL J. Biol. Chem. 280:13600-13605 (2005).
RN [43]; RE0049512.
RX PUBMED: 16428452.
RA Bartholin L., Powers S. E., Melhuish T. A., Lasse S., Weinstein M., Wotton D.
RT TGIF inhibits retinoid signaling.
RL Mol. Cell. Biol. 26:990-1001 (2006).
RN [44]; RE0050196.
RX PUBMED: 15987634.
RA Bouaboula M., Hilairet S., Marchand J., Fajas L., Le Fur G., Casellas P.
RT Anandamide induced PPARgamma transcriptional activation and 3T3-L1 preadipocyte differentiation.
RL Eur. J. Pharmacol. 517:174-181 (2005).
RN [45]; RE0050235.
RX PUBMED: 11956198.
RA Kozak K. R., Gupta R. A., Moody J. S., Ji C., Boeglin W. E., DuBois R. N., Brash A. R., Marnett L. J.
RT 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist.
RL J. Biol. Chem. 277:23278-23286 (2002).
RN [46]; RE0050244.
RX PUBMED: 16236024.
RA Shiraki T., Kodama T. S., Shiki S., Nakagawa T., Jingami H.
RT Spectroscopic analyses of the binding kinetics of 15d-PGJ2 to the PPARgamma ligand-binding domain by multi-wavelength global fitting.
RL Biochem. J. 393:749-755 (2006).
RN [47]; RE0050254.
RX PUBMED: 12711249.
RA Nixon J. B., Kamitani H., Baek S. J., Eling T. E.
RT Evaluation of eicosanoids and NSAIDs as PPARgamma ligands in colorectal carcinoma cells.
RL Prostaglandins Leukot. Essent. Fatty Acids 68:323-330 (2003).
RN [48]; RE0050293.
RX PUBMED: 9449199.
RA Johnson T. E., Holloway M. K., Vogel R., Rutledge S. J., Perkins J. J., Rodan G. A., Schmidt A.
RT Structural requirements and cell-type specificity for ligand activation of peroxisome proliferator-activated receptors.
RL J. Steroid Biochem. Mol. Biol. 63:1-8 (1997).
RN [49]; RE0050372.
RX PUBMED: 17604003.
RA Altmann R., Hausmann M., Spottl T., Gruber M., Bull A. W., Menzel K., Vogl D., Herfarth H., Scholmerich J., Falk W., Rogler G.
RT 13-Oxo-ODE is an endogenous ligand for PPARgamma in human colonic epithelial cells.
RL Biochem. Pharmacol. 74:612-622 (2007).
RN [50]; RE0050379.
RX PUBMED: 15695504.
RA Shiraki T., Kamiya N., Shiki S., Kodama T. S., Kakizuka A., Jingami H.
RT Alpha,beta-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma.
RL J. Biol. Chem. 280:14145-14153 (2005).
RN [51]; RE0050526.
RX PUBMED: 11027271.
RA Yang W., Rachez C., Freedman L. P.
RT Discrete roles for peroxisome proliferator-activated receptor gamma and retinoid X receptor in recruiting nuclear receptor coactivators.
RL Mol. Cell. Biol. 20:8008-8017 (2000).
RN [52]; RE0050609.
RX PUBMED: 17101779.
RA Burgermeister E., Chuderland D., Hanoch T., Meyer M., Liscovitch M., Seger R.
RT Interaction with MEK causes nuclear export and downregulation of peroxisome proliferator-activated receptor gamma.
RL Mol. Cell. Biol. 27:803-817 (2007).
RN [53]; RE0050639.
RX PUBMED: 17611194.
RA Yong X., Farmer S. R., Smith B. D.
RT PPARgamma interacts with CIITA/RFX5 complex to repress collagen type I gene expression.
RL J. Biol. Chem. 282:26046-26056 (2007).
RN [54]; RE0050933.
RX PUBMED: 16127449.
RA Pascual G., Fong A. L., Ogawa S., Gamliel A., Li A. C., Perissi V., Rose D. W., Willson T. M., Rosenfeld M. G., Glass C. K.
RT A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma.
RL Nature 437:759-763 (2005).
RN [55]; RE0053453.
RX PUBMED: 9637681.
RA Rachez C., Suldan Z., Ward J., Chang C. P., Burakov D., Erdjument-Bromage H., Tempst P., Freedman L. P.
RT A novel protein complex that interacts with the vitamin D3 receptor in a ligand-dependent manner and enhances VDR transactivation in a cell-free system.
RL Genes Dev. 12:1787-1800 (1998).
RN [56]; RE0055277.
RX PUBMED: 10934192.
RA Chung S. W., Kang B. Y., Kim S. H., Pak Y. K., Cho D., Trinchieri G., Kim T. S.
RT Oxidized low density lipoprotein inhibits interleukin-12 production in lipopolysaccharide-activated mouse macrophages via direct interactions between peroxisome proliferator-activated receptor-gamma and nuclear factor-kappa B.
RL J. Biol. Chem. 275:32681-32687 (2000).
RN [57]; RE0066731.
RX PUBMED: 16106032.
RA Akerblad P., Mansson R., Lagergren A., Westerlund S., Basta B., Lind U., Thelin A., Gisler R., Liberg D., Nelander S., Bamberg K., Sigvardsson M.
RT Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics.
RL Physiol. Genomics 23:206-216 (2005).
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