AC T23084
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ID T23084
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DT 10.03.2005 (created); nvo.
DT 03.10.2012 (updated); spk.
CO Copyright (C), QIAGEN.
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FA SHP
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SY small heterodimer partner.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T08487 AR-isoform1; human, Homo sapiens.
IN T10818 arnt; Mammalia.
IN T23079 CAR; Mammalia.
IN T09637 ER-alpha; Mammalia.
IN T16015 ER-beta; Mammalia.
IN T14760 ERR1; Mammalia.
IN T14067 FOXO1A; Mammalia.
IN T21852 HDAC1; Mammalia.
IN T08612 HNF-4alpha; Mammalia.
IN T08880 LRH-1; Mammalia.
IN T17874 LXR-alpha; Mammalia.
IN T14436 NeuroD-1; Mammalia.
IN T09956 PPARalpha; Mammalia.
IN T09963 PPARgamma; Mammalia.
IN T09964 RXR-alpha; Mammalia.
IN T21552 SRC-1; Mammalia.
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DR TRANSPATH: MO000046927.
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RN [1]; RE0006318.
RX PUBMED: 8650544.
RA Seol W., Choi H. S., Moore D. D.
RT An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors
RL Science 272:1336-1339 (1996).
RN [2]; RE0022566.
RX PUBMED: 11368516.
RA Klinge C. M., Jernigan S. C., Risinger K. E., Lee J. E., Tyulmenkov V. V., Falkner K. C., Prough R. A.
RT Short heterodimer partner (SHP) orphan nuclear receptor inhibits the transcriptional activity of aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT).
RL Arch. Biochem. Biophys. 390:64-70 (2001).
RN [3]; RE0032544.
RX PUBMED: 15000748.
RA Bae Y., Kemper J. K., Kemper B.
RT Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP).
RL DNA Cell Biol. 23:81-91 (2004).
RN [4]; RE0038317.
RX PUBMED: 10594021.
RA Lee Y. K., Dell H., Dowhan D. H., Hadzopoulou-Cladaras M., Moore D. D.
RT The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression
RL Mol. Cell. Biol. 20:187-95 (2000).
RN [5]; RE0042145.
RX PUBMED: 11369442.
RA Kassam A., Capone J. P., Rachubinski R. A.
RT The short heterodimer partner receptor differentially modulates peroxisome proliferator-activated receptor alpha-mediated transcription from the peroxisome proliferator-response elements of the genes encoding the peroxisomal beta-oxidation enzymes acyl-CoA oxidase and hydratase-dehydrogenase
RL Mol. Cell. Endocrinol. 176:49-56 (2001).
RN [6]; RE0042742.
RX PUBMED: 11705994.
RA Sanyal S., Kim J. Y., Kim H. J., Takeda J., Lee Y. K., Moore D. D., Choi H. S.
RT Differential regulation of the orphan nuclear receptor small heterodimer partner (SHP) gene promoter by orphan nuclear receptor ERR isoforms
RL J. Biol. Chem. 277:1739-48 (2002).
RN [7]; RE0042872.
RX PUBMED: 15047713.
RA Yamagata K., Daitoku H., Shimamoto Y., Matsuzaki H., Hirota K., Ishida J., Fukamizu A.
RT Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1
RL J. Biol. Chem. 279:23158-65 (2004).
RN [8]; RE0042875.
RX PUBMED: 11696534.
RA Nishizawa H., Yamagata K., Shimomura I., Takahashi M., Kuriyama H., Kishida K., Hotta K., Nagaretani H., Maeda N., Matsuda M., Kihara S., Nakamura T., Nishigori H., Tomura H., Moore D. D., Takeda J., Funahashi T., Matsuzawa Y.
RT Small heterodimer partner, an orphan nuclear receptor, augments peroxisome proliferator-activated receptor gamma transactivation
RL J. Biol. Chem. 277:1586-92 (2002).
RN [9]; RE0042878.
RX PUBMED: 12062084.
RA Kerr T. A., Saeki S., Schneider M., Schaefer K., Berdy S., Redder T., Shan B., Russell D. W., Schwarz M.
RT Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis
RL Dev. Cell 2:713-20 (2002).
RN [10]; RE0042891.
RX PUBMED: 12198243.
RA Brendel C., Schoonjans K., Botrugno O. A., Treuter E., Auwerx J.
RT The Small Heterodimer Partner Interacts with the Liver X Receptor alpha and Represses Its Transcriptional Activity
RL Mol. Endocrinol. 16:2065-76 (2002).
RN [11]; RE0042892.
RX PUBMED: 11448950.
RA Kim Y. S., Han C. Y., Kim S. W., Kim J. H., Lee S. K., Jung D. J., Park S. Y., Kang H., Choi H. S., Lee J. W., Pak Y. K.
RT The orphan nuclear receptor small heterodimer partner as a novel coregulator of nuclear factor-kappa b in oxidized low density lipoprotein-treated macrophage cell line RAW 264.7
RL J. Biol. Chem. 276:33736-40 (2001).
RN [12]; RE0050336.
RX PUBMED: 17587566.
RA Meyer R., Wolf S. S., Obendorf M.
RT PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor.
RL J. Steroid Biochem. Mol. Biol. 107:1-14 (2007).
RN [13]; RE0051082.
RX PUBMED: 17895379.
RA Sanyal S., Bavner A., Haroniti A., Nilsson L. M., Lundasen T., Rehnmark S., Witt M. R., Einarsson C., Talianidis I., Gustafsson J. A., Treuter E.
RT Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis.
RL Proc. Natl. Acad. Sci. USA 104:15665-15670 (2007).
RN [14]; RE0053638.
RX PUBMED: 16488887.
RA Song K. H., Li T., Chiang J. Y.
RT A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene.
RL J. Biol. Chem. 281:10081-10088 (2006).
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