TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T23079 XX ID T23079 XX DT 10.03.2005 (created); nvo. DT 03.05.2013 (updated); jtr. CO Copyright (C), QIAGEN. XX FA CAR XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX IN T28267 PGC-1; Mammalia. IN T09964 RXR-alpha; Mammalia. IN T23084 SHP; Mammalia. XX MX M00966 V$DR3_Q4. MX M00965 V$DR4_Q2. MX M07280 V$NR1NR2_Q3. MX M00964 V$PXR_Q2. XX BS R27841. XX DR TRANSPATH: MO000046512. XX RN [1]; RE0006318. RX PUBMED: 8650544. RA Seol W., Choi H. S., Moore D. D. RT An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors RL Science 272:1336-1339 (1996). RN [2]; RE0018044. RX PUBMED: 10660604. RA Kassam A., Winrow C. J., Fernandez-Rachubinski F., Capone J. P., Rachubinski R. A. RT The peroxisome proliferator response element of the gene encoding the peroxisomal beta-oxidation enzyme enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase is a target for constitutive androstane receptor beta/9-cis-retinoic acid receptor-mediated transactivation. RL J. Biol. Chem. 275:4345-4350 (2000). RN [3]; RE0018105. RX PUBMED: 11706036. RA Kast H. R., Goodwin B., Tarr P. T., Jones S. A., Anisfeld A. M., Stoltz C. M., Tontonoz P., Kliewer S., Willson T. M., Edwards P. A. RT Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. RL J. Biol. Chem. 277:2908-2915 (2002). RN [4]; RE0023235. RX PUBMED: 11502872. RA Goodwin B., Moore L. B., Stoltz C. M., McKee D. D., Kliewer S. A. RT Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor. RL Mol. Pharmacol. 60:427-431 (2001). RN [5]; RE0030969. RX PUBMED: 14573755. RA Kobayashi K., Sueyoshi T., Inoue K., Moore R., Negishi M. RT Cytoplasmic accumulation of the nuclear receptor CAR by a tetratricopeptide repeat protein in HepG2 cells. RL Mol. Pharmacol. 64:1069-75 (2003). RN [6]; RE0035541. RX PUBMED: 12881517. RA Fraser D. J., Zumsteg A., Meyer U. A. RT Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene. RL J. Biol. Chem. 278:39392-39401 (2003). RN [7]; RE0036452. RX PUBMED: 12566446. RA Yueh M. F., Huang Y. H., Hiller A., Chen S., Nguyen N., Tukey R. H. RT Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1 RL J. Biol. Chem. 278:15001-6 (2003). RN [8]; RE0036497. RX PUBMED: 11752118. RA Guo G. L., Choudhuri S., Klaassen C. D. RT Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways RL J. Pharmacol. Exp. Ther. 300:206-12 (2002). RN [9]; RE0038353. RX PUBMED: 8603043. RA Choi H. S., Seol W., Moore D. D. RT A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily RL J. Steroid Biochem. Mol. Biol. 56:23-30 (1996). RN [10]; RE0039631. RX PUBMED: 14742670. RA Saini S. P., Sonoda J., Xu L., Toma D., Uppal H., Mu Y., Ren S., Moore D. D., Evans R. M., Xie W. RT A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification RL Mol. Pharmacol. 65:292-300 (2004). RN [11]; RE0040939. RX PUBMED: 15004031. RA Maglich J. M., Watson J., McMillen P. J., Goodwin B., Willson T. M., Moore J. T. RT The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction RL J. Biol. Chem. 279:19832-8 (2004). RN [12]; RE0040940. RX PUBMED: 11162490. RA Bertilsson G., Berkenstam A., Blomquist P. RT Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7 RL Biochem. Biophys. Res. Commun. 280:139-44 (2001). RN [13]; RE0040942. RX PUBMED: 11861787. RA Van Ess P. J., Mattson M. P., Blouin R. A. RT Enhanced induction of cytochrome P450 enzymes and CAR binding in TNF (p55(-/-)/p75(-/-)) double receptor knockout mice following phenobarbital treatment RL J. Pharmacol. Exp. Ther. 300:824-30 (2002). RN [14]; RE0040945. RX PUBMED: 15004017. RA Assem M., Schuetz E. G., Leggas M., Sun D., Yasuda K., Reid G., Zelcer N., Adachi M., Strom S., Evans R. M., Moore D. D., Borst P., Schuetz J. D. RT Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice RL J. Biol. Chem. 279:22250-7 (2004). RN [15]; RE0040947. RX PUBMED: 12695338. RA Staudinger J. L., Madan A., Carol K. M., Parkinson A. RT Regulation of drug transporter gene expression by nuclear receptors RL Drug Metab. Dispos. 31:523-7 (2003). RN [16]; RE0040948. RX PUBMED: 12869636. RA Chen Y., Ferguson S. S., Negishi M., Goldstein J. A. RT Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter RL Mol. Pharmacol. 64:316-24 (2003). RN [17]; RE0040949. RX PUBMED: 12896978. RA Frank C., Gonzalez M. M., Oinonen C., Dunlop T. W., Carlberg C. RT Characterization of DNA complexes formed by the nuclear receptor constitutive androstane receptor RL J. Biol. Chem. 278:43299-310 (2003). RN [18]; RE0040951. RX PUBMED: 12181452. RA Ferguson S. S., LeCluyse E. L., Negishi M., Goldstein J. A. RT Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site RL Mol. Pharmacol. 62:737-46 (2002). RN [19]; RE0040961. RX PUBMED: 12000748. RA Min G., Kemper J. K., Kemper B. RT Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo RL J. Biol. Chem. 277:26356-63 (2002). RN [20]; RE0040965. RX PUBMED: 11353743. RA Blizard D., Sueyoshi T., Negishi M., Dehal S. S., Kupfer D. RT Mechanism of induction of cytochrome p450 enzymes by the proestrogenic endocrine disruptor pesticide-methoxychlor: interactions of methoxychlor metabolites with the constitutive androstane receptor system RL Drug Metab. Dispos. 29:781-5 (2001). RN [21]; RE0046689. RX PUBMED: 12551939. RA Shiraki T., Sakai N., Kanaya E., Jingami H. RT Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state RL J. Biol. Chem. 278:11344-50 (2003). RN [22]; RE0050548. RX PUBMED: 16554032. RA Surapureddi S., Viswakarma N., Yu S., Guo D., Rao MS., Reddy JK. RT PRIC320, a transcription coactivator, isolated from peroxisome proliferator-binding protein complex. RL Biochem. Biophys. Res. Commun. 343:535-43 (2006). XX //