AC T10818
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ID T10818
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DT 10.03.2005 (created); nvo.
DT 30.09.2015 (updated); hna.
CO Copyright (C), QIAGEN.
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FA arnt
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SY Ah receptor nuclear translocator; Arnt; aryl hydrocarbon receptor nuclear translocator; HIF-1beta; hypoxia-inducible factor 1beta.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T23080 AhR; Mammalia.
IN T15204 brca1; Mammalia.
IN T09637 ER-alpha; Mammalia.
IN T16015 ER-beta; Mammalia.
IN T17446 HIF-1alpha-isoform2; human, Homo sapiens.
IN T10516 HIF-1alpha; Mammalia.
IN T15683 HIF2A; Mammalia.
IN T08612 HNF-4alpha; Mammalia.
IN T23091 p300; Mammalia.
IN T23084 SHP; Mammalia.
IN T08326 Sp1; Mammalia.
IN T21552 SRC-1; Mammalia.
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MX M00235 V$AHRARNT_01.
MX M00237 V$AHRARNT_02.
MX M00976 V$AHRHIF_Q6.
MX M08868 V$ARNTLIKE_Q6.
MX M00236 V$ARNT_01.
MX M00539 V$ARNT_02.
MX M03812 V$ARNT_Q6.
MX M08800 V$ARNT_Q6_01.
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BS R40617.
BS R24274.
BS R41060.
BS R42172.
BS R30398.
BS R66241.
BS R66222.
BS R00270.
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DR TRANSPATH: MO000047645.
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RN [1]; RE0013592.
RX PUBMED: 9079689.
RA Hogenesch J. B., Chan W. K., Jackiw V. H., Brown R. C., Gu Y.-Z., Pray-Grant M., Perdew G. H., Bradfield C. A.
RT Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
RL J. Biol. Chem. 272:8581-8593 (1997).
RN [2]; RE0021482.
RX PUBMED: 12097158.
RA Tsuchiya T., Kominato Y., Ueda M.
RT Human Hypoxic Signal Transduction through a Signature Motif in Hepatocyte Nuclear Factor 4
RL J. Biochem. 132:37-44 (2002).
RN [3]; RE0022293.
RX PUBMED: 11593383.
RA Suzuki H., Tomida A., Tsuruo T.
RT Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia.
RL Oncogene 20:5779-5788 (2001).
RN [4]; RE0022546.
RX PUBMED: 12024042.
RA Beischlag T. V., Wang S., Rose D. W., Torchia J., Reisz-Porszasz S., Muhammad K., Nelson W. E., Probst M. R., Rosenfeld M. G., Hankinson O.
RT Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex.
RL Mol. Cell. Biol. 22:4319-4333 (2002).
RN [5]; RE0022566.
RX PUBMED: 11368516.
RA Klinge C. M., Jernigan S. C., Risinger K. E., Lee J. E., Tyulmenkov V. V., Falkner K. C., Prough R. A.
RT Short heterodimer partner (SHP) orphan nuclear receptor inhibits the transcriptional activity of aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT).
RL Arch. Biochem. Biophys. 390:64-70 (2001).
RN [6]; RE0022582.
RX PUBMED: 11805098.
RA Wang S., Hankinson O.
RT Functional involvement of the Brahma/SWI2-related gene 1 protein in cytochrome P4501A1 transcription mediated by the aryl hydrocarbon receptor complex.
RL J. Biol. Chem. 277:11821-11827 (2002).
RN [7]; RE0026527.
RX PUBMED: 10799490.
RA Takahashi Y., Takahashi S., Shiga Y., Yoshimi T., Miura T.
RT Hypoxic induction of prolyl 4-hydroxylase alpha (I) in cultured cells.
RL J. Biol. Chem. 275:14139-46 (2000).
RN [8]; RE0034111.
RX PUBMED: 12051661.
RA Kohle C., Hassepass I., Bock-Hennig B. S., Walter Bock K., Poellinger L., McGuire J.
RT Conditional expression of a constitutively active aryl hydrocarbon receptor in MCF-7 human breast cancer cells.
RL Arch. Biochem. Biophys. 402:172-9 (2002).
RN [9]; RE0034409.
RX PUBMED: 12939282.
RA Kunz M., Moeller S., Koczan D., Lorenz P., Wenger R. H., Glocker M. O., Thiesen H. J., Gross G., Ibrahim S. M.
RT Mechanisms of hypoxic gene regulation of angiogenesis factor Cyr61 in melanoma cells.
RL J. Biol. Chem. 278:45651-60 (2003).
RN [10]; RE0034540.
RX PUBMED: 12376470.
RA Husbeck B., Powis G.
RT The redox protein thioredoxin-1 regulates the constitutive and inducible expression of the estrogen metabolizing cytochromes P450 1B1 and 1A1 in MCF-7 human breast cancer cells.
RL Carcinogenesis 23:1625-30 (2002).
RN [11]; RE0038646.
RX PUBMED: 12147270.
RA Ma Q.
RT Induction and superinduction of 2,3,7,8-tetrachlorodibenzo-rho-dioxin-inducible poly(ADP-ribose) polymerase: role of the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator transcription activation domains and a labile transcription repressor
RL Arch. Biochem. Biophys. 404:309-16 (2002).
RN [12]; RE0038949.
RX PUBMED: 12752442.
RA Gess B., Hofbauer K. H., Wenger R. H., Lohaus C., Meyer H. E., Kurtz A.
RT The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha
RL Eur. J. Biochem. 270:2228-35 (2003).
RN [13]; RE0042579.
RX PUBMED: 11084652.
RA Abbott B. D., Buckalew A. R.
RT Placental defects in ARNT-knockout conceptus correlate with localized decreases in VEGF-R2, ang-1, and tie-2
RL Dev. Dyn. 219:526-38 (2000).
RN [14]; RE0045600.
RX PUBMED: 15288808.
RA Shetty P. V., Wang X., Chan W. K.
RT CyP40, but not Hsp70, in rabbit reticulocyte lysate causes the aryl hydrocarbon receptor-DNA complex formation
RL Arch. Biochem. Biophys. 429:42-9 (2004).
RN [15]; RE0045607.
RX PUBMED: 15144902.
RA Sogawa K., Numayama-Tsuruta K., Takahashi T., Matsushita N., Miura C., Nikawa J., Gotoh O., Kikuchi Y., Fujii-Kuriyama Y.
RT A novel induction mechanism of the rat CYP1A2 gene mediated by Ah receptor-Arnt heterodimer
RL Biochem. Biophys. Res. Commun. 318:746-55 (2004).
RN [16]; RE0045608.
RX PUBMED: 11043581.
RA Tomita S., Sinal C. J., Yim S. H., Gonzalez F. J.
RT Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha
RL Mol. Endocrinol. 14:1674-81 (2000).
RN [17]; RE0045609.
RX PUBMED: 14701734.
RA Ooe N., Saito K., Mikami N., Nakatuka I., Kaneko H.
RT Identification of a novel basic helix-loop-helix-PAS factor, NXF, reveals a Sim2 competitive, positive regulatory role in dendritic-cytoskeleton modulator drebrin gene expression
RL Mol. Cell. Biol. 24:608-16 (2004).
RN [18]; RE0045647.
RX PUBMED: 9840812.
RA Gu Y. Z., Moran S. M., Hogenesch J. B., Wartman L., Bradfield C. A.
RT Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha
RL Gene Expr. 7:205-13 (1998).
RN [19]; RE0046748.
RX PUBMED: 12754377.
RA Brunnberg S., Pettersson K., Rydin E., Matthews J., Hanberg A., Pongratz I.
RT The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription
RL Proc. Natl. Acad. Sci. USA 100:6517-22 (2003).
RN [20]; RE0050884.
RX PUBMED: 16567799.
RA Kang H. J., Kim H. J., Kim S. K., Barouki R., Cho C. H., Khanna K. K., Rosen E. M., Bae I.
RT BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells.
RL J. Biol. Chem. 281:14654-14662 (2006).
RN [21]; RE0063464.
RX PUBMED: 16484282.
RA Metz R. P., Kwak H. I., Gustafson T., Laffin B., Porter W. W.
RT Differential transcriptional regulation by mouse single-minded 2s.
RL J. Biol. Chem. 281:10839-10848 (2006).
RN [22]; RE0069699.
RX PUBMED: 16397226.
RA Csiki I., Yanagisawa K., Haruki N., Nadaf S., Morrow J. D., Johnson D. H., Carbone D. P.
RT Thioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1alpha in non-small cell lung cancer.
RL Cancer Res. 66:143-150 (2006).
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