AC T33929
XX
ID T33929
XX
DT 10.04.2006 (created); man.
DT 27.03.2012 (updated); yre.
CO Copyright (C), QIAGEN.
XX
FA DRIP205-isoform1
XX
SY Activator-recruited cofactor 205 kDa component; ARC205; DRIP205; p53 regulatory protein RB18A; PBP; peroxisome proliferator-activated receptor binding protein; Peroxisome proliferator-activated receptor-binding protein; PPAR binding protein; PPAR-binding protein; PPARBP; RB18A; thyroid hormone receptor interactor 2; Thyroid hormone receptor-associated protein complex 220 kDa component; thyroid hormone receptor-associated protein complex component TRAP220; thyroid receptor interacting protein 2; Thyroid receptor-interacting protein 2; TRAP220; TRIP-2; TRIP2; vitamin D receptor-interacting protein complex component DRIP205.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004939 MED1; HGNC: MED1.
XX
SZ 1581 AA; 168.5 kDa (cDNA) (calc.).
XX
SQ MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVS
SQ CLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQL
SQ CDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSL
SQ EQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYVSPSDLLDDKTASPI
SQ ILHENNVSRSLGMNASVTIEGTSAVYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLP
SQ ACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPIPLNHN
SQ MRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTL
SQ IGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLY
SQ KGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNL
SQ PPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQ
SQ NPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTL
SQ YGSSPLERQNSSSGSPRMEICSGSNKTKKKKSSRLPPEKPKHQTEDDFQRELFSMDVDSQ
SQ NPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVT
SQ DILSDIAEEASKLPSTSDDCPAIGTPLRDSSSSGHSQSTLFDSDVFQTNNNENPYTDPAD
SQ LIADAAGSPSSDSPTNHFFHDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFAS
SQ QALNTLGVPMLGGDNGETKFKGNNQADTVDFSIISVAGKALAPADLMEHHSGSQGPLLTT
SQ GDLGKEKTQKRVKEGNGTSNSTLSGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGK
SQ SPSHSSSNRPFTPPTSTGGSKSPGSAGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSH
SQ SQYTSSGSVSSSGSKSHHSHSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGS
SQ SQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPG
SQ GSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTSSSSGMKSSSGLGSSGSLSQKTP
SQ PSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPG
SQ GEDPLDGQMGVSTNSSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGSSVDSSKKTSE
SQ SKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGST
SQ PKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKH
SQ KKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRL
SQ SPDFMIGEEDDDLMDVALIGN
XX
SC Swiss-Prot#Q15648-1
XX
IN T08487 AR-isoform1; human, Homo sapiens.
IN T08300 ER-alpha-L; human, Homo sapiens.
IN T05299 NR1B1; human, Homo sapiens.
IN T08255 PGC-1-isoform1; mouse, Mus musculus.
IN T02726 PPARalpha; human, Homo sapiens.
IN T05332 PPARgamma2; mouse, Mus musculus.
IN T08433 RXR-alpha; human, Homo sapiens.
IN T01152 T3R-alpha1; human, Homo sapiens.
IN T08482 VDR-isoform1; human, Homo sapiens.
XX
DR TRANSPATH: MO000080002.
DR EMBL: AF055994;
DR EMBL: AF283812; AF283812.
DR EMBL: L40366;
DR EMBL: Y13467;
DR UniProtKB: Q15648-1;
XX
RN [1]; RE0025974.
RX PUBMED: 9653119.
RA Yuan C. X., Ito M., Fondell J. D., Fu Z. Y., Roeder R. G.
RT The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
RL Proc. Natl. Acad. Sci. USA 95:7939-44 (1998).
RN [2]; RE0030588.
RX PUBMED: 14636573.
RA Wallberg A. E., Yamamura S., Malik S., Spiegelman B. M., Roeder R. G.
RT Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha.
RL Mol. Cell 12:1137-49 (2003).
RN [3]; RE0047548.
RX PUBMED: 10733574.
RA Rachez C., Gamble M., Chang C. P., Atkins G. B., Lazar M. A., Freedman L. P.
RT The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes.
RL Mol. Cell. Biol. 20:2718-2726 (2000).
RN [4]; RE0053029.
RX PUBMED: 12796488.
RA Yamamoto H., Shevde N. K., Warrier A., Plum L. A., DeLuca H. F., Pike J. W.
RT 2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts.
RL J. Biol. Chem. 278:31756-31765 (2003).
RN [5]; RE0073074.
RX PUBMED: 22102282.
RA Jin F., Claessens F., Fondell J. D.
RT Regulation of androgen receptor-dependent transcription by coactivator MED1 is mediated through a newly discovered noncanonical binding motif.
RL J. Biol. Chem. 287:858-870 (2012).
XX
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