TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02726 XX ID T02726 XX DT 27.05.1999 (created); mpr. DT 25.11.2014 (updated); hna. CO Copyright (C), QIAGEN. XX FA PPARalpha XX SY NR1C1; peroxisome proliferator-activated receptor alpha; PPARalpha. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002888 PPARA; HGNC: PPARA. XX CL C0002; CC (rec); XX SF forms heterodimers with RXR-alpha; SF 91% amino acid sequence identity with mouse PPAR T00694 [1]; XX FF activator as a heterodimer with RXR-alpha [1]; FF activated by (ligands) nafenopin, clofibrate, WY-14,643 [1]; FF mRNA is repressed during hypoxia [3]; XX IN T33929 DRIP205-isoform1; human, Homo sapiens. IN T08711 RelA-p65; human, Homo sapiens. IN T04807 RXR-gamma; human, Homo sapiens. IN T08236 RXR; mouse, Mus musculus. XX MX M00242 V$PPARA_01. MX M00518 V$PPARA_02. MX M01282 V$PPARA_Q6. MX M00763 V$PPARDR1_Q2. XX BS R62541. BS R62546. BS R62549. BS R19257. BS R27282. BS R27271. BS R64999. BS R65000. BS R65003. BS R70166. BS R57420. BS R62903. BS R27487. BS R61284. BS R27356. BS R27362. BS R27215. XX DR TRANSPATH: MO000026702. DR PATHODB: MT010529. DR UniProtKB: Q07869; PPARA_HUMAN. XX RN [1]; RE0013611. RX PUBMED: 7684926. RA Sher T., Yi H. F., McBride O. W., Gonzalez F. J. RT cDNA cloning, chromosomal mapping, and functional characterization of the human peroxisome proliferator activated receptor RL Biochemistry 32:5598-5604 (1993). RN [2]; RE0013625. RX PUBMED: 10219237. RA Nuclear Receptors Nomenclature Committee. RT A unified nomenclature system for the nuclear receptor superfamily RL Cell 97:161-163 (1999). RN [3]; RE0022204. RX PUBMED: 11390509. RA Narravula S., Colgan S. P. RT Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia. RL J. Immunol. 166:7543-7548 (2001). RN [4]; RE0025974. RX PUBMED: 9653119. RA Yuan C. X., Ito M., Fondell J. D., Fu Z. Y., Roeder R. G. RT The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion RL Proc. Natl. Acad. Sci. USA 95:7939-44 (1998). RN [5]; RE0047375. RX PUBMED: 11891224. RA Gonzalez M. M., Carlberg C. RT Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. RL J. Biol. Chem. 277:18501-18509 (2002). RN [6]; RE0047782. RX PUBMED: 12444922. RA Babb R., Bowen B. R. RT SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain. RL Biochem. J. 370:719-727 (2003). RN [7]; RE0063261. RX PUBMED: 16169070. RA Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F. H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., Timm J., Mintzlaff S., Abraham C., Bock N., Kietzmann S., Goedde A., Toksoz E., Droege A., Krobitsch S., Korn B., Birchmeier W., Lehrach H., Wanker E. E. RT A human protein-protein interaction network: a resource for annotating the proteome. RL Cell 122:957-968 (2005). RN [8]; RE0065504. RX PUBMED: 19823578. RA Wray J. A., Sugden M. C., Zeldin D. C., Greenwood G. K., Samsuddin S., Miller-Degraff L., Bradbury J. A., Holness M. J., Warner T. D., Bishop-Bailey D. RT The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo. RL PLoS ONE 4:e7421 (2009). RN [9]; RE0066377. RX PUBMED: 12107827. RA Nickoloff B. J., Qin J. Z., Chaturvedi V., Denning M. F., Bonish B., Miele L. RT Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. RL Cell Death Differ. 9:842-855 (2002). RN [10]; RE0066859. RX PUBMED: 20400503. RA Narala V. R., Adapala R. K., Suresh M. V., Brock T. G., Peters-Golden M., Reddy R. C. RT Leukotriene B4 is a physiologically relevant endogenous peroxisome proliferator-activated receptor-{alpha} agonist. RL J. Biol. Chem. 285:22067-22074 (2010). XX //