AC T00694
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ID T00694
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DT 27.01.1993 (created); hse.
DT 24.09.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA PPARalpha
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SY NR1C1; peroxisome proliferator-activated receptor; peroxisome proliferator-activated receptor alpha; PPAR; PPARalpha.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G004881 Ppara.
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CL C0002; CC (rec); 2.1.2.5.1.
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SF requires heterodimerization with RXR (RXRalpha) for DNA-binding;
SF binds to direct repeat elements with 1bp spacing (DR1) [3];
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CP liver, kidney, heart, brown adipose tissue cells.
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FF PPARalpha regulates myocardial as well as hepatic lipid metabolism [15];
FF member of the steroid hormone receptor superfamily;
FF control of peroxisomal beta-oxidation pathway;
FF reduces LXR-alpha:RXR-alpha heterodimerization in liver [6];
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IN T01318 CBP; mouse, Mus musculus.
IN T09997 Hsp90; mouse, Mus musculus.
IN T04688 NCOR1; mouse, Mus musculus.
IN T19194 PRIC285; human, Homo sapiens.
IN T01331 RXR-alpha; mouse, Mus musculus.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T01359 RXR-alpha; clawed frog, Xenopus laevis.
IN T04639 SRC-1; mouse, Mus musculus.
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MX M00242 V$PPARA_01.
MX M00518 V$PPARA_02.
MX M01282 V$PPARA_Q6.
MX M00763 V$PPARDR1_Q2.
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BS R69798.
BS R62843.
BS R68826.
BS R66788.
BS R38520.
BS R69797.
BS R72447.
BS R72449.
BS R72450.
BS R61243.
BS R61252.
BS R61255.
BS R02233.
BS R04600.
BS R20237.
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DR TRANSPATH: MO000025112.
DR UniProtKB: P23204;
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RN [1]; RE0000272.
RX PUBMED: 1312391.
RA Dreyer C., Krey G., Keller H., Givel F., Helftenbein G., Wahli W.
RT Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors
RL Cell 68:879-887 (1992).
RN [2]; RE0001932.
RX PUBMED: 2129546.
RA Issemann I., Green S.
RT Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
RL Nature 347:645-650 (1990).
RN [3]; RE0003809.
RX PUBMED: 7608174.
RA Palmer C. N. A., Hsu M.-H., Griffin K. J., Johnson E. F.
RT Novel sequence determinants in peroxisome proliferator signaling
RL J. Biol. Chem. 270:16114-16121 (1995).
RN [4]; RE0018238.
RX PUBMED: 12189208.
RA Surapureddi S., Yu S., Bu H., Hashimoto T., Yeldandi A. V., Kashireddy P., Cherkaoui-Malki M., Qi C., Zhu Y. J., Rao M. S., Reddy J. K.
RT Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.
RL Proc. Natl. Acad. Sci. USA 99:11836-11841 (2002).
RN [5]; RE0018281.
RX PUBMED: 8041794.
RA Kliewer S. A., Forman B. M., Blumberg B., Ong E. S., Borgmeyer U., Mangelsdorf D. J., Umesono K., Evans R. M.
RT Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.
RL Proc. Natl. Acad. Sci. USA 91:7355-7359 (1994).
RN [6]; RE0025510.
RX PUBMED: 12730331.
RA Yoshikawa T., Ide T., Shimano H., Yahagi N., Amemiya-Kudo M., Matsuzaka T., Yatoh S., Kitamine T., Okazaki H., Tamura Y., Sekiya M., Takahashi A., Hasty A. H., Sato R., Sone H., Osuga J., Ishibashi S., Yamada N.
RT Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.
RL Mol. Endocrinol. 17:1240-1254 (2003).
RN [7]; RE0032314.
RX PUBMED: 12482853.
RA Sumanasekera W. K., Tien E. S., Turpey R., Vanden Heuvel J. P., Perdew G. H.
RT Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2.
RL J. Biol. Chem. 278:4467-73 (2003).
RN [8]; RE0035800.
RX PUBMED: 10872826.
RA Yi Y. W., Kim D., Jung N., Hong S. S., Lee H. S., Bae I.
RT Gadd45 family proteins are coactivators of nuclear hormone receptors.
RL Biochem. Biophys. Res. Commun. 272:193-198 (2000).
RN [9]; RE0040896.
RX PUBMED: 11226238.
RA Wolfrum C., Borrmann C. M., Borchers T., Spener F.
RT Fatty acids and hypolipidemic drugs regulate peroxisome proliferator-activated receptors alpha - and gamma -mediated gene expression via liver fatty acid binding protein: A signaling path to the nucleus
RL Proc. Natl. Acad. Sci. USA 98:2323-2328 (2001).
RN [10]; RE0042462.
RX PUBMED: 10753967.
RA Hanley K., Komuves L. G., Ng D. C., Schoonjans K., He S. S., Lau P., Bikle D. D., Williams M. L., Elias P. M., Auwerx J., Feingold K. R.
RT Farnesol stimulates differentiation in epidermal keratinocytes via PPARalpha
RL J. Biol. Chem. 275:11484-91 (2000).
RN [11]; RE0050076.
RX PUBMED: 15774422.
RA Hostetler H. A., Petrescu A. D., Kier A. B., Schroeder F.
RT Peroxisome proliferator-activated receptor alpha interacts with high affinity and is conformationally responsive to endogenous ligands.
RL J. Biol. Chem. 280:18667-18682 (2005).
RN [12]; RE0050322.
RX PUBMED: 16768463.
RA Hostetler H. A., Kier A. B., Schroeder F.
RT Very-long-chain and branched-chain fatty acyl-CoAs are high affinity ligands for the peroxisome proliferator-activated receptor alpha (PPARalpha).
RL Biochemistry 45:7669-7681 (2006).
RN [13]; RE0054769.
RX PUBMED: 16807375.
RA Shin M., Kim I., Inoue Y., Kimura S., Gonzalez F. J.
RT Regulation of mouse hepatic alpha-amino-beta-carboxymuconate-epsilon-semialdehyde decarboxylase, a key enzyme in the tryptophan-nicotinamide adenine dinucleotide pathway, by hepatocyte nuclear factor 4alpha and peroxisome proliferator-activated receptor alpha.
RL Mol. Pharmacol. 70:1281-1290 (2006).
RN [14]; RE0054953.
RX PUBMED: 18445591.
RA Qiu L., Wu X., Chau J. F., Szeto I. Y., Tam W. Y., Guo Z., Chung S. K., Oates P. J., Chung S. S., Yang J. Y.
RT Aldose reductase regulates hepatic peroxisome proliferator-activated receptor alpha phosphorylation and activity to impact lipid homeostasis.
RL J. Biol. Chem. 283:17175-17183 (2008).
RN [15]; RE0026869.
RX PUBMED: 9726988.
RA Brandt J. M., Djouadi F., Kelly D. P.
RT Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha.
RL J. Biol. Chem. 273:23786-92 (1998).
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