AC T04639
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ID T04639
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DT 24.07.2001 (created); mas.
DT 03.06.2013 (updated); spk.
CO Copyright (C), QIAGEN.
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FA SRC-1
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SY MSRC-1; NCOA-1; NCOA1; nuclear receptor coactivator 1; steroid receptor coactivator-1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002758 Ncoa1.
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CL C0010; bHLH; 1.2.5.3.1.
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FF coactivator for the steroid hormone receptor superfamily [1];
FF binds directly to several nuclear receptors, for example mFXRbeta [2];
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IN T05687 CAR; mouse, Mus musculus.
IN T15118 CBP; Mammalia.
IN T00259 ER-alpha; mouse, Mus musculus.
IN T09602 ER; Mammalia.
IN T10857 LXR-alpha; mouse, Mus musculus.
IN T05299 NR1B1; human, Homo sapiens.
IN T00694 PPARalpha; mouse, Mus musculus.
IN T08431 PPARalpha; mouse, Mus musculus.
IN T23101 PXR; Mammalia.
IN T01330 RAR-gamma1; human, Homo sapiens.
IN T08348 RXR-alpha; mouse, Mus musculus.
IN T09519 SF-1-isoform1; mouse, Mus musculus.
IN T01574 STAT3; mouse, Mus musculus.
IN T01580 STAT6; human, Homo sapiens.
IN T08482 VDR-isoform1; human, Homo sapiens.
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DR TRANSPATH: MO000028472.
DR UniProtKB: P70365;
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RN [1]; RE0016476.
RX PUBMED: 10713439.
RA Leo C., Chen J. D.
RT The SRC family of nuclear receptor coactivators
RL Gene 245:1-11 (2000).
RN [2]; RE0023352.
RX PUBMED: 12529392.
RA Otte K., Kranz H., Kober I., Thompson P., Hoefer M., Haubold B., Remmel B., Voss H., Kaiser C., Albers M., Cheruvallath Z., Jackson D., Casari G., Koegl M., Paabo S., Mous J., Kremoser C., Deuschle U.
RT Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol.
RL Mol. Cell. Biol. 23:864-872 (2003).
RN [3]; RE0029151.
RX PUBMED: 11773079.
RA Giraud S., Bienvenu F., Avril S., Gascan H., Heery D. M., Coqueret O.
RT Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.
RL J. Biol. Chem. 277:8004-11 (2002).
RN [4]; RE0030488.
RX PUBMED: 12507421.
RA Picard F., Gehin M., Annicotte J., Rocchi S., Champy M. F., O'Malley B. W., Chambon P., Auwerx J.
RT SRC-1 and TIF2 control energy balance between white and brown adipose tissues.
RL Cell 111:931-41 (2002).
RN [5]; RE0048891.
RX PUBMED: 15923603.
RA Hong C. Y., Suh J. H., Kim K., Gong E. Y., Jeon S. H., Ko M., Seong R. H., Kwon H. B., Lee K.
RT Modulation of androgen receptor transactivation by the SWI3-related gene product (SRG3) in multiple ways.
RL Mol. Cell. Biol. 25:4841-4852 (2005).
RN [6]; RE0050076.
RX PUBMED: 15774422.
RA Hostetler H. A., Petrescu A. D., Kier A. B., Schroeder F.
RT Peroxisome proliferator-activated receptor alpha interacts with high affinity and is conformationally responsive to endogenous ligands.
RL J. Biol. Chem. 280:18667-18682 (2005).
RN [7]; RE0050322.
RX PUBMED: 16768463.
RA Hostetler H. A., Kier A. B., Schroeder F.
RT Very-long-chain and branched-chain fatty acyl-CoAs are high affinity ligands for the peroxisome proliferator-activated receptor alpha (PPARalpha).
RL Biochemistry 45:7669-7681 (2006).
RN [8]; RE0051015.
RX PUBMED: 12004058.
RA Cui J., Heard T. S., Yu J., Lo J. L., Huang L., Li Y., Schaeffer J. M., Wright S. D.
RT The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate.
RL J. Biol. Chem. 277:25963-25969 (2002).
RN [9]; RE0051265.
RX PUBMED: 17296605.
RA Yamamoto T., Shimano H., Inoue N., Nakagawa Y., Matsuzaka T., Takahashi A., Yahagi N., Sone H., Suzuki H., Toyoshima H., Yamada N.
RT Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver.
RL J. Biol. Chem. 282:11687-11695 (2007).
RN [10]; RE0051298.
RX PUBMED: 10707959.
RA Masuyama H., Hiramatsu Y., Kunitomi M., Kudo T., MacDonald P. N.
RT Endocrine disrupting chemicals, phthalic acid and nonylphenol, activate Pregnane X receptor-mediated transcription.
RL Mol. Endocrinol. 14:421-428 (2000).
RN [11]; RE0051799.
RX PUBMED: 9280066.
RA Masuyama H., Brownfield C. M., St-Arnaud R., MacDonald P. N.
RT Evidence for ligand-dependent intramolecular folding of the AF-2 domain in vitamin D receptor-activated transcription and coactivator interaction.
RL Mol. Endocrinol. 11:1507-1517 (1997).
RN [12]; RE0052028.
RX PUBMED: 10318858.
RA Kraichely D. M., Collins JJ 3. r. d., DeLisle R. K., MacDonald P. N.
RT The autonomous transactivation domain in helix H3 of the vitamin D receptor is required for transactivation and coactivator interaction.
RL J. Biol. Chem. 274:14352-14358 (1999).
RN [13]; RE0065548.
RX PUBMED: 19574399.
RA Chen J., An B. S., Cheng L., Hammond G. L., Leung P. C.
RT Gonadotropin-releasing hormone-mediated phosphorylation of estrogen receptor-alpha contributes to fosB expression in mouse gonadotrophs.
RL Endocrinology 150:4583-4593 (2009).
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