AC T10857
XX
ID T10857
XX
DT 26.09.2007 (created); bch.
DT 21.07.2014 (updated); yre.
CO Copyright (C), QIAGEN.
XX
FA LXR-alpha
XX
SY liver X receptor alpha; LXR; LXR A; LXR-A; NR1H3; nuclear orphan receptor LXR-alpha; oxysterol receptor LXR-alpha; oxysterol receptor LXRalpha; RLD1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G002739 Nr1h3.
XX
CL C0002; CC (rec); 2.1.2.7.1.1.
XX
SZ 445 AA; 50.5 kDa (cDNA) (calc.).
XX
SQ MSLWLEASMPDVSPDSATELWKTEPQDAGDQGGNTCILREEARMPQSTGVALGIGLESAE
SQ PTALLPRAETLPEPTELRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFF
SQ RRSVIKGARYVCHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQ
SQ EEEQAQATSVSPRVSSPPQVLPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPIAP
SQ DPQSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLET
SQ SRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAI
SQ SIFSADRPNVQDQLQVERLQHTYVEALHAYVSINHPHDRLMFPRMLMKLVSLRTLSSVHS
SQ EQVFALRLQDKKLPPLLSEIWDVHE
XX
SC translated from EMBL #AJ132599
XX
FT 93 164 
SM00399; c4gold.
FT 93 168 
PS51030; NUCLEAR_REC_DBD_2.
FT 94 169 
PF00105; Zinc finger, C4 type (two domains).
FT 104 397 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 257 416 
SM00430; holi.
FT 260 440 
PF00104; Ligand-binding domain of nuclear hormon.
FT 265 304 
putative transcriptional activation domain [2].
FT 317 412 
putative dimerization domain [2].
FT 436 442 
C-terminal stretch of hydrophic and charged residues [2].
XX
IN T08641 NCOR1-isoform1; mouse, Mus musculus.
IN T04639 SRC-1; mouse, Mus musculus.
XX
MX M00965 V$DR4_Q2.
MX M00647 V$LXR_Q3.
MX M03795 V$LXR_Q6.
MX M07280 V$NR1NR2_Q3.
XX
BS R09969.
BS R28552.
BS R28551.
BS R31143.
BS R60116.
BS R09968.
XX
DR TRANSPATH: MO000114386.
DR EMBL: AF085745;
DR EMBL: AJ132599;
DR UniProtKB: Q9Z0Y9;
XX
RN [1]; RE0010391.
RX PUBMED: 7744246.
RA Willy P. J., Umesono K., Ong E. S., Evans R. M., Heyman R. A., Mangelsdorf D. J.
RT LXR, a nuclear receptor that defines a distinct retinoid response pathway
RL Genes Dev. 9:1033-1045 (1995).
RN [2]; RE0016052.
RX PUBMED: 7935418.
RA Apfel R., Benbrook D., Lernhardt E., Ortiz M. A., Salbert G., Pfahl M.
RT A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily
RL Mol. Cell. Biol. 14:7025-7035 (1994).
RN [3]; RE0016108.
RX PUBMED: 9013544.
RA Lehmann J. M., Kliewer S. A., Moore L. B., Smith-Oliver T. A., Oliver B. B., Su J. L., Sundseth S. S., Winegar D. A., Blanchard D. E., Spencer T. A., Willson T. M.
RT Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
RL J. Biol. Chem. 272:3137-3140 (1997).
RN [4]; RE0016118.
RX PUBMED: 11035776.
RA Venkateswaran A., Laffitte B. A., Joseph S. B., Mak P. A., Wilpitz D. C., Edwards P. A., Tontonoz P.
RT Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha
RL Proc. Natl. Acad. Sci. USA 97:12097-12102 (2000).
RN [5]; RE0016121.
RX PUBMED: 11287605.
RA Yoshikawa T., Shimano H., Amemiya-Kudo M., Yahagi N., Hasty A. H., Matsuzaka T., Okazaki H., Tamura Y., Iizuka Y., Ohashi K., Osuga J. I., Harada K., Gotoda T., Kimura S., Ishibashi S., Yamada N.
RT Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter
RL Mol. Cell. Biol. 21:2991-3000 (2001).
RN [6]; RE0016208.
RX PUBMED: 11030331.
RA Lu T. T., Makishima M., Repa J. J., Schoonjans K., Kerr T. A., Auwerx J., Mangelsdorf D. J.
RT Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
RL Mol. Cell 6:507-515 (2000).
RN [7]; RE0023359.
RX PUBMED: 10858438.
RA Costet P., Luo Y., Wang N., Tall A. R.
RT Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor.
RL J. Biol. Chem. 275:28240-28245 (2000).
RN [8]; RE0023594.
RX PUBMED: 11781314.
RA Tobin K. A., Ulven S. M., Schuster G. U., Steineger H. H., Andresen S. M., Gustafsson J. A., Nebb H. I.
RT Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis.
RL J. Biol. Chem. 277:10691-10697 (2002).
RN [9]; RE0051160.
RX PUBMED: 12847102.
RA Kaneko E., Matsuda M., Yamada Y., Tachibana Y., Shimomura I., Makishima M.
RT Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist.
RL J. Biol. Chem. 278:36091-36098 (2003).
RN [10]; RE0051265.
RX PUBMED: 17296605.
RA Yamamoto T., Shimano H., Inoue N., Nakagawa Y., Matsuzaka T., Takahashi A., Yahagi N., Sone H., Suzuki H., Toyoshima H., Yamada N.
RT Protein kinase A suppresses sterol regulatory element-binding protein-1C expression via phosphorylation of liver X receptor in the liver.
RL J. Biol. Chem. 282:11687-11695 (2007).
XX
//