TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01574 XX ID T01574 XX DT 24.11.1995 (created); ewi. DT 23.03.2016 (updated); ros. CO Copyright (C), QIAGEN. XX FA STAT3 XX SY acute-phase response factor; APRF; signal transducer and activator of transcription 3. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005732 Stat3. XX CL C0039; STAT; XX SF tyrosine-phosphorylation [2] [4]; XX CP mammary tissues [40]; Bone marrow cells [42]. XX FF MPA (medroxyprogesterone acetate) inducible [45]; FF Increased expression in involution due to phosphorylation of Tyr 705 residue [40]; FF activator; FF functionally related to SIF (c-sis-inducible element-binding factor) [2]; FF activated by EGF and IL-6, not by IFN-gamma, by tyrosine phosphorylation [2] [4]; FF also modified by other cytokines whose receptors share the gp130 component [4]; FF maximal transcriptional activation after additional phosphorylation of Ser-727, possibly by MAP kinase [5]; FF activation induced by IFN-alpha and CSF-1 and IL-10 [8] [11]; FF positive autoregulation of the stat3 gene by the STAT3 factor [10]; XX IN T01318 CBP; mouse, Mus musculus. IN T00261 ER-alpha; human, Homo sapiens. IN T00305 GATA-1; mouse, Mus musculus. IN T10217 GATA-1; Mammalia. IN T17995 GATA-2; Mammalia. IN T04680 PR; mouse, Mus musculus. IN T04639 SRC-1; mouse, Mus musculus. IN T01575 STAT1alpha; mouse, Mus musculus. IN T01574 STAT3; mouse, Mus musculus. IN T27164 Tip60; human, Homo sapiens. XX MX M00225 V$STAT3_01. MX M00497 V$STAT3_02. MX M01595 V$STAT3_03. MX M07065 V$STAT3_Q4. MX M00223 V$STAT_01. MX M00777 V$STAT_Q6. XX BS R11779. BS R25860. BS R29395. BS R20996. BS R27391. BS R24063. BS R07556. BS R14619. BS R14236. BS R60283. BS R11115. BS R08485. BS R37129. BS R25957. BS R26890. BS R04223. BS R29841. BS R29842. BS R66285. BS R62245. BS R72615. BS R38535. BS R24504. BS R27183. BS R27184. BS R27185. BS R67262. BS R20985. BS R68092. BS R68087. BS R27180. BS R27181. BS R66162. BS R66163. BS R66164. BS R66165. BS R20772. BS R20777. BS R27182. BS R39069. BS R64795. BS R35594. BS R64319. BS R16945. BS R73957. BS R61507. BS R26293. BS R65222. BS R14495. BS R29859. BS R37122. BS R60638. BS R67266. BS R56944. BS R63903. BS R19616. BS R17088. BS R17089. BS R63917. BS R13581. BS R68661. BS R40230. BS R14446. BS R29885. BS R04650. BS R04652. XX DR TRANSPATH: MO000025777. DR TRANSCOMPEL: C00187. DR TRANSCOMPEL: C00294. DR TRANSCOMPEL: C00304. DR TRANSCOMPEL: C00392. DR TRANSCOMPEL: C00642. DR UniProtKB: P42227; XX RN [1]; RE0003481. RX PUBMED: 7774815. RA Horvath C. M., Wen Z., Darnell jr J. E. RT A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain RL Genes Dev. 9:984-994 (1995). RN [2]; RE0003503. RX PUBMED: 8140422. RA Zhong Z., Wen Z., Darnell J. E. RT Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6 RL Science 264:95-98 (1994). RN [3]; RE0003504. RX PUBMED: 7545930. RA Zhong Z., Wen Z., Darnell J. E. RT Stat3 and Stat4: members of the family of signal transducers and activators of transcription RL Proc. Natl. Acad. Sci. USA 91:4806-4810 (1994). RN [4]; RE0003506. RX PUBMED: 7512451. RA Akira S., Nishio Y., Inoue M., Wang X. J., Shi W., Matsusaka T., Yoshida K., Sudo T., Naruto M., Kishimoto T. RT Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway RL Cell 77:63-71 (1994). RN [5]; RE0003507. RX PUBMED: 7543024. RA Wen Z., Zhong Z., Darnell J. E. RT Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosophorylation RL Cell 82:241-250 (1995). RN [6]; RE0006063. RX PUBMED: 9009201. RA Liu X., Robinson G. W., Wagner K.-U., Garrett L., Wynshaw-Boris A., Hennighausen L. RT Stat5a is mandatory for adult mammary gland development and lactogenesis RL Genes Dev. 11:179-186 (1997). RN [7]; RE0010751. RX PUBMED: 7538664. RA Ruff-Jamison S., Chen K., Cohen S. RT Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver RL Proc. Natl. Acad. Sci. USA 92:4215-4218 (1995). RN [8]; RE0011175. RX PUBMED: 7588632. RA Hill C. S., Treisman R. RT Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors RL EMBO J. 14:5037-5047 (1995). RN [9]; RE0012661. RX PUBMED: 8670868. RA Nakajima K., Yamanaka Y., Nakae K., Kojima H., Ichiba M., Kiuchi N., Kitaoka T., Fukada T., Hibi M., Hirano T. RT A central role for Stat3 in IL-6-induced regulation of growth and differentiation in M1 leukemia cells RL EMBO J. 15:3651-3658 (1996). RN [10]; RE0023186. RX PUBMED: 9497331. RA Ichiba M., Nakajima K., Yamanaka Y., Kiuchi N., Hirano T. RT Autoregulation of the Stat3 gene through cooperation with a cAMP-responsive element-binding protein. RL J. Biol. Chem. 273:6132-6138 (1998). RN [11]; RE0023360. RX PUBMED: 8830676. RA Wehinger J., Gouilleux F., Groner B., Finke J., Mertelsmann R., Weber-Nordt R. M. RT IL-10 induces DNA binding activity of three STAT proteins (Stat1, Stat3, and Stat5) and their distinct combinatorial assembly in the promoters of selected genes. RL FEBS Lett. 394:365-370 (1996). RN [12]; RE0023482. RX PUBMED: 12244095. RA Schreiner S. J., Schiavone A. P., Smithgall T. E. RT Activation of STAT3 by the Src family kinase Hck requires a functional SH3 domain. RL J. Biol. Chem. 277:45680-45687 (2002). RN [13]; RE0025604. RX PUBMED: 10455148. RA Nakayama K., Hara T., Hibi M., Hirano T., Miyajima A. RT A novel oncostatin M-inducible gene OIG37 forms a gene family with MyD118 and GADD45 and negatively regulates cell growth. RL J. Biol. Chem. 274:24766-72 (1999). RN [14]; RE0026644. RX PUBMED: 10823829. RA Zhang Y., Turkson J., Carter-Su C., Smithgall T., Levitzki A., Kraker A., Krolewski J. J., Medveczky P., Jove R. RT Activation of stat3 in v-src-transformed fibroblasts requires cooperation of jak1 kinase activity RL J. Biol. Chem. 275:24935-44 (2000). RN [15]; RE0026736. RX PUBMED: 10859312. RA Tanuma N., Nakamura K., Shima H., Kikuchi K. RT Protein-tyrosine phosphatase PTPepsilon C inhibits Jak-STAT signaling and differentiation induced by interleukin-6 and leukemia inhibitory factor in M1 leukemia cells. RL J. Biol. Chem. 275:28216-21 (2000). RN [16]; RE0029151. RX PUBMED: 11773079. RA Giraud S., Bienvenu F., Avril S., Gascan H., Heery D. M., Coqueret O. RT Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a. RL J. Biol. Chem. 277:8004-11 (2002). RN [17]; RE0030568. RX PUBMED: 12959977. RA Duplomb L., Chaigne-Delalande B., Vusio P., Raher S., Jacques Y., Godard A., Blanchard F. RT Soluble mannose 6-phosphate/insulin-like growth factor II (IGF-II) receptor inhibits interleukin-6-type cytokine-dependent proliferation by neutralization of IGF-II. RL Endocrinology 144:5381-9 (2003). RN [18]; RE0030772. RX PUBMED: 12817006. RA Bode J. G., Schweigart J., Kehrmann J., Ehlting C., Schaper F., Heinrich P. C., Haussinger D. RT TNF-alpha induces tyrosine phosphorylation and recruitment of the Src homology protein-tyrosine phosphatase 2 to the gp130 signal-transducing subunit of the IL-6 receptor complex. RL J. Immunol. 171:257-66 (2003). RN [19]; RE0031901. RX PUBMED: 12707269. RA Plun-Favreau H., Perret D., Diveu C., Froger J., Chevalier S., Lelievre E., Gascan H., Chabbert M. RT Leukemia inhibitory factor (LIF), cardiotrophin-1, and oncostatin M share structural binding determinants in the immunoglobulin-like domain of LIF receptor. RL J. Biol. Chem. 278:27169-79 (2003). RN [20]; RE0031906. RX PUBMED: 15012602. RA Auernhammer C. J., Dorn F., Vlotides G., Hengge S., Kopp F. B., Spoettl G., Cengic N., Engelhardt D., Weber M. M. RT The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells. RL J. Endocrinol. 180:479-86 (2004). RN [21]; RE0032739. RX PUBMED: 9642280. RA Yeung Y. G., Wang Y., Einstein D. B., Lee P. S., Stanley E. R. RT Colony-stimulating factor-1 stimulates the formation of multimeric cytosolic complexes of signaling proteins and cytoskeletal components in macrophages. RL J. Biol. Chem. 273:17128-37 (1998). RN [22]; RE0038473. RX PUBMED: 11418668. RA Reche P. A., Soumelis V., Gorman D. M., Clifford T., Liu Mr, Travis M., Zurawski S. M., Johnston J., Liu Y. J., Spits H., de Waal Malefyt R., Kastelein R. A., Bazan J. F. RT Human thymic stromal lymphopoietin preferentially stimulates myeloid cells RL J. Immunol. 167:336-43 (2001). RN [23]; RE0042098. RX PUBMED: 11689697. RA Schaeffer M., Schneiderbauer M., Weidler S., Tavares R., Warmuth M., de Vos G., Hallek M. RT Signaling through a novel domain of gp130 mediates cell proliferation and activation of Hck and Erk kinases RL Mol. Cell. Biol. 21:8068-81 (2001). RN [24]; RE0043173. RX PUBMED: 9405487. RA Bjorbaek C., Uotani S., da Silva B., Flier J. S. RT Divergent signaling capacities of the long and short isoforms of the leptin receptor RL J. Biol. Chem. 272:32686-95 (1997). RN [25]; RE0047093. RX PUBMED: 14685156. RA Duval D., Malaise M., Reinhardt B., Kedinger C., Boeuf H. RT A p38 inhibitor allows to dissociate differentiation and apoptotic processes triggered upon LIF withdrawal in mouse embryonic stem cells RL Cell Death Differ. 11:331-41 (2004). RN [26]; RE0047322. RX PUBMED: 15673499. RA Ezoe S., Matsumura I., Gale K., Satoh Y., Ishikawa J., Mizuki M., Takahashi S., Minegishi N., Nakajima K., Yamamoto M., Enver T., Kanakura Y. RT GATA transcription factors inhibit cytokine-dependent growth and survival of a hematopoietic cell line through the inhibition of STAT3 activity. RL J. Biol. Chem. 280:13163-13170 (2005). RN [27]; RE0047407. RX PUBMED: 15284113. RA Tonozuka Y., Minoshima Y., Bao Y. C., Moon Y., Tsubono Y., Hatori T., Nakajima H., Nosaka T., Kawashima T., Kitamura T. RT A GTPase-activating protein binds STAT3 and is required for IL-6-induced STAT3 activation and for differentiation of a leukemic cell line. RL Blood 104:3550-3557 (2004). RN [28]; RE0047424. RX PUBMED: 15465816. RA Huang Y., Li T., Sane D. C., Li L. RT IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression. RL J. Biol. Chem. 279:51697-51703 (2004). RN [29]; RE0047437. RX PUBMED: 16199887. RA Tannahill G. M., Elliott J., Barry A. C., Hibbert L., Cacalano N. A., Johnston J. A. RT SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation. RL Mol. Cell. Biol. 25:9115-9126 (2005). RN [30]; RE0047808. RX PUBMED: 12738762. RA Taler M., Shpungin S., Salem Y., Malovani H., Pasder O., Nir U. RT Fer is a downstream effector of insulin and mediates the activation of signal transducer and activator of transcription 3 in myogenic cells. RL Mol. Endocrinol. 17:1580-1592 (2003). RN [31]; RE0047988. RX PUBMED: 15385932. RA Cho-Vega J. H., Rassidakis G. Z., Amin H. M., Tsioli P., Spurgers K., Remache Y. K., Vega F., Goy A. H., Gilles F., Medeiros L. J. RT Suppressor of cytokine signaling 3 expression in anaplastic large cell lymphoma. RL Leukemia 18:1872-1878 (2004). RN [32]; RE0049596. RX PUBMED: 15063116. RA Sarcar B., Ghosh A. K., Steele R., Ray R., Ray R. B. RT Hepatitis C virus NS5A mediated STAT3 activation requires co-operation of Jak1 kinase. RL Virology 322:51-60 (2004). RN [33]; RE0049976. RX PUBMED: 17434128. RA Huang W. C., Ju T. K., Hung M. C., Chen C. C. RT Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. RL Mol. Cell 26:75-87 (2007). RN [34]; RE0050787. RX PUBMED: 14498832. RA Zhang T., Ma J., Cao X. RT Grb2 regulates Stat3 activation negatively in epidermal growth factor signalling. RL Biochem. J. 376:457-464 (2003). RN [35]; RE0050815. RX PUBMED: 12873986. RA Shao H., Cheng H. Y., Cook R. G., Tweardy D. J. RT Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor. RL Cancer Res. 63:3923-3930 (2003). RN [36]; RE0051833. RX PUBMED: 11821424. RA Xie J., LeBaron M. J., Nevalainen M. T., Rui H. RT Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells. RL J. Biol. Chem. 277:14020-14030 (2002). RN [37]; RE0052011. RX PUBMED: 15572665. RA Sonnenblick A., Levy C., Razin E. RT Interplay between MITF, PIAS3, and STAT3 in mast cells and melanocytes. RL Mol. Cell. Biol. 24:10584-10592 (2004). RN [38]; RE0052377. RX PUBMED: 16901783. RA Guo W., Pylayeva Y., Pepe A., Yoshioka T., Muller W. J., Inghirami G., Giancotti F. G. RT Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. RL Cell 126:489-502 (2006). RN [39]; RE0052420. RX PUBMED: 8961260. RA Liu X., Robinson G. W., Hennighausen L. RT Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation. RL Mol. Endocrinol. 10:1496-1506 (1996). RN [40]; RE0052684. RX PUBMED: 8906870. RA Philp J. A., Burdon T. G., Watson C. J. RT Differential activation of STATs 3 and 5 during mammary gland development. RL FEBS Lett. 396:77-80 (1996). RN [41]; RE0052718. RX PUBMED: 11113455. RA Yamamoto T., Matsuda T., Junicho A., Kishi H., Saatcioglu F., Muraguchi A. RT Cross-talk between signal transducer and activator of transcription 3 and estrogen receptor signaling. RL FEBS Lett. 486:143-148 (2000). RN [42]; RE0052834. RX PUBMED: 16819138. RA Fu Z., Huang D., Cai J., Chen Q., Han L., Li B., Wang F., Gao J. RT Expression changes of ERK1/2, STAT3 and SHP-2 in bone marrow cells from gamma-ray induced leukemia mice. RL J. Radiat. Res. 47:121-130 (2006). RN [43]; RE0052859. RX PUBMED: 17027227. RA Godeny M. D., Sayyah J., VonDerLinden D., Johns M., Ostrov D. A., Caldwell-Busby J., Sayeski P. P. RT The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor. RL Cell. Signal. 19:600-609 (2007). RN [44]; RE0052895. RX PUBMED: 18077349. RA Ma Z., Gong Y., Patel V., Karner C. M., Fischer E., Hiesberger T., Carroll T. J., Pontoglio M., Igarashi P. RT Mutations of HNF-1beta inhibit epithelial morphogenesis through dysregulation of SOCS-3. RL Proc. Natl. Acad. Sci. USA 104:20386-20391 (2007). RN [45]; RE0053327. RX PUBMED: 15923602. RA Proietti C., Salatino M., Rosemblit C., Carnevale R., Pecci A., Kornblihtt A. R., Molinolo A. A., Frahm I., Charreau E. H., Schillaci R., Elizalde P. V. RT Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells. RL Mol. Cell. Biol. 25:4826-4840 (2005). RN [46]; RE0053637. RX PUBMED: 18490754. RA Vargas-Inchaustegui D. A., Xin L., Soong L. RT Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses. RL J. Immunol. 180:7537-7545 (2008). RN [47]; RE0053797. RX PUBMED: 16123385. RA Forrai A., Boyle K., Hart A. H., Hartley L., Rakar S., Willson T. A., Simpson K. M., Roberts A. W., Alexander W. S., Voss A. K., Robb L. RT Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cells. RL Stem Cells 24:604-614 (2006). RN [48]; RE0053877. RX PUBMED: 17925034. RA Quaglino A., Schere-Levy C., Romorini L., Meiss R. P., Kordon E. C. RT Mouse mammary tumors display Stat3 activation dependent on leukemia inhibitory factor signaling. RL Breast Cancer Res. 9:R69 (2007). RN [49]; RE0054009. RX PUBMED: 11457894. RA Ernst M., Inglese M., Waring P., Campbell I. K., Bao S., Clay F. J., Alexander W. S., Wicks I. P., Tarlinton D. M., Novak U., Heath J. K., Dunn A. R. RT Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation. RL J. Exp. Med. 194:189-203 (2001). RN [50]; RE0054351. RX PUBMED: 15292206. RA Zhao L., Hart S., Cheng J., Melenhorst J. J., Bierie B., Ernst M., Stewart C., Schaper F., Heinrich P. C., Ullrich A., Robinson G. W., Hennighausen L. RT Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK. RL J. Biol. Chem. 279:44093-44100 (2004). RN [51]; RE0054613. RX PUBMED: 17726024. RA Gong Y., Ishida-Takahashi R., Villanueva E. C., Fingar D. C., Munzberg H., Myers MG J. r. RT The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms. RL J. Biol. Chem. 282:31019-31027 (2007). RN [52]; RE0054661. RX PUBMED: 18782771. RA Hou T., Ray S., Lee C., Brasier A. R. RT The STAT3 NH2-terminal Domain Stabilizes Enhanceosome Assembly by Interacting with the p300 Bromodomain. RL J. Biol. Chem. 283:30725-30734 (2008). RN [53]; RE0055096. RX PUBMED: 12456808. RA Zhao L., Melenhorst J. J., Hennighausen L. RT Loss of interleukin 6 results in delayed mammary gland involution: a possible role for mitogen-activated protein kinase and not signal transducer and activator of transcription 3. RL Mol. Endocrinol. 16:2902-2912 (2002). RN [54]; RE0055160. RX PUBMED: 10364425. RA Burdon T., Stracey C., Chambers I., Nichols J., Smith A. RT Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. RL Dev. Biol. 210:30-43 (1999). RN [55]; RE0063497. RX PUBMED: 18192275. RA Bai Y., Ahmad U., Wang Y., Li J. H., Choy J. C., Kim R. W., Kirkiles-Smith N., Maher S. E., Karras J. G., Bennett C. F., Bothwell A. L., Pober J. S., Tellides G. RT Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation. RL J. Biol. Chem. 283:6832-6842 (2008). RN [56]; RE0063709. RX PUBMED: 18641358. RA Fielding C. A., McLoughlin R. M., McLeod L., Colmont C. S., Najdovska M., Grail D., Ernst M., Jones S. A., Topley N., Jenkins B. J. RT IL-6 regulates neutrophil trafficking during acute inflammation via STAT3. RL J. Immunol. 181:2189-2195 (2008). RN [57]; RE0063840. RX PUBMED: 17567983. RA Chalaris A., Rabe B., Paliga K., Lange H., Laskay T., Fielding C. A., Jones S. A., Rose-John S., Scheller J. RT Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. RL Blood 110:1748-1755 (2007). RN [58]; RE0063914. RX PUBMED: 17932422. RA Guo Y., Mantel C., Hromas R. A., Broxmeyer H. E. RT Oct-4 is critical for survival/antiapoptosis of murine embryonic stem cells subjected to stress: effects associated with Stat3/survivin. RL Stem Cells 26:30-34 (2008). RN [59]; RE0064415. RX PUBMED: 18467660. RA Tam W. L., Lim C. Y., Han J., Zhang J., Ang Y. S., Ng H. H., Yang H., Lim B. RT T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. RL Stem Cells 26:2019-2031 (2008). RN [60]; RE0064592. RX PUBMED: 15328362. RA Paling N. R., Wheadon H., Bone H. K., Welham M. J. RT Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. RL J. Biol. Chem. 279:48063-48070 (2004). RN [61]; RE0064701. RX PUBMED: 15277698. RA Humphrey R. K., Beattie G. M., Lopez A. D., Bucay N., King C. C., Firpo M. T., Rose-John S., Hayek A. RT Maintenance of pluripotency in human embryonic stem cells is STAT3 independent. RL Stem Cells 22:522-530 (2004). RN [62]; RE0064723. RX PUBMED: 19088203. RA Huber M., Brustle A., Reinhard K., Guralnik A., Walter G., Mahiny A., von Low E., Lohoff M. RT IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. RL Proc. Natl. Acad. Sci. USA 105:20846-20851 (2008). RN [63]; RE0064812. RX PUBMED: 15694390. RA Jeon S. B., Ji K. A., You H. J., Kim J. H., Jou I., Joe E. H. RT Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes. RL Biochem. Biophys. Res. Commun. 328:595-600 (2005). RN [64]; RE0064863. RX PUBMED: 18614536. RA Ozawa Y., Nakao K., Kurihara T., Shimazaki T., Shimmura S., Ishida S., Yoshimura A., Tsubota K., Okano H. RT Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation. RL J. Biol. Chem. 283:24561-24570 (2008). RN [65]; RE0064901. RX PUBMED: 16705160. RA Ishida-Takahashi R., Rosario F., Gong Y., Kopp K., Stancheva Z., Chen X., Feener E. P., Myers MG J. r. RT Phosphorylation of Jak2 on Ser(523) inhibits Jak2-dependent leptin receptor signaling. RL Mol. Cell. Biol. 26:4063-4073 (2006). RN [66]; RE0064990. RX PUBMED: 18715881. RA Labeur M., Refojo D., Wolfel B., Stalla J., Vargas V., Theodoropoulou M., Buchfelder M., Paez-Pereda M., Arzt E., Stalla G. K. RT Interferon-gamma inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway. RL J. Endocrinol. 199:177-189 (2008). RN [67]; RE0065171. RX PUBMED: 15649407. RA Ramana C. V., Kumar A., Enelow R. RT Stat1-independent induction of SOCS-3 by interferon-gamma is mediated by sustained activation of Stat3 in mouse embryonic fibroblasts. RL Biochem. Biophys. Res. Commun. 327:727-733 (2005). RN [68]; RE0065367. RX PUBMED: 15284232. RA Qing Y., Stark G. R. RT Alternative activation of STAT1 and STAT3 in response to interferon-gamma. RL J. Biol. Chem. 279:41679-41685 (2004). RN [69]; RE0065384. RX PUBMED: 15930175. RA Hogan J. C., Stephens J. M. RT Effects of leukemia inhibitory factor on 3T3-L1 adipocytes. RL J. Endocrinol. 185:485-496 (2005). RN [70]; RE0065425. RX PUBMED: 19632985. RA Dumoutier L., de Meester C., Tavernier J., Renauld J. C. RT New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain. RL J. Biol. Chem. 284:26377-26384 (2009). RN [71]; RE0065662. RX PUBMED: 16000408. RA Du Z., Shen Y., Yang W., Mecklenbrauker I., Neel B. G., Ivashkiv L. B. RT Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway. RL Proc. Natl. Acad. Sci. USA 102:10267-10272 (2005). RN [72]; RE0065712. RX PUBMED: 18362156. RA Yang C. H., Murti A., Pfeffer S. R., Fan M., Du Z., Pfeffer L. M. RT The role of TRAF2 binding to the type I interferon receptor in alternative NF kappaB activation and antiviral response. RL J. Biol. Chem. 283:14309-14316 (2008). RN [73]; RE0065726. RX PUBMED: 16698929. RA Chen Z., Laurence A., Kanno Y., Pacher-Zavisin M., Zhu B. M., Tato C., Yoshimura A., Hennighausen L., O'Shea J. J. RT Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. RL Proc. Natl. Acad. Sci. USA 103:8137-8142 (2006). RN [74]; RE0065767. RX PUBMED: 19064501. RA Su H. W., Wang S. W., Ghishan F. K., Kiela P. R., Tang M. J. RT Cell confluency-induced Stat3 activation regulates NHE3 expression by recruiting Sp1 and Sp3 to the proximal NHE3 promoter region during epithelial dome formation. RL Am. J. Physiol. Cell Physiol. 296:C13-24 (2009). RN [75]; RE0065994. RX PUBMED: 15166220. RA Dumoutier L., Tounsi A., Michiels T., Sommereyns C., Kotenko S. V., Renauld J. C. RT Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling. RL J. Biol. Chem. 279:32269-32274 (2004). RN [76]; RE0066419. RX PUBMED: 11070174. RA Shimoda K., Kato K., Aoki K., Matsuda T., Miyamoto A., Shibamori M., Yamashita M., Numata A., Takase K., Kobayashi S., Shibata S., Asano Y., Gondo H., Sekiguchi K., Nakayama K., Nakayama T., Okamura T., Okamura S., Niho Y., Nakayama K. RT Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. RL Immunity 13:561-571 (2000). RN [77]; RE0066808. RX PUBMED: 12646580. RA Ancey C., Kuster A., Haan S., Herrmann A., Heinrich P. C., Muller-Newen G. RT A fusion protein of the gp130 and interleukin-6Ralpha ligand-binding domains acts as a potent interleukin-6 inhibitor. RL J. Biol. Chem. 278:16968-16972 (2003). RN [78]; RE0066821. RX PUBMED: 10623831. RA Schmitz J., Dahmen H., Grimm C., Gendo C., Muller-Newen G., Heinrich P. C., Schaper F. RT The cytoplasmic tyrosine motifs in full-length glycoprotein 130 have different roles in IL-6 signal transduction. RL J. Immunol. 164:848-854 (2000). RN [79]; RE0066945. RX PUBMED: 16254248. RA Giese B., Roderburg C., Sommerauer M., Wortmann S. B., Metz S., Heinrich P. C., Muller-Newen G. RT Dimerization of the cytokine receptors gp130 and LIFR analysed in single cells. RL J. Cell Sci. 118:5129-5140 (2005). RN [80]; RE0066960. RX PUBMED: 12974672. RA Kretzschmar A. K., Dinger M. C., Henze C., Brocke-Heidrich K., Horn F. RT Analysis of Stat3 (signal transducer and activator of transcription 3) dimerization by fluorescence resonance energy transfer in living cells. RL Biochem. J. 377:289-297 (2004). RN [81]; RE0067228. RX PUBMED: 12643274. RA Schuster B., Kovaleva M., Sun Y., Regenhard P., Matthews V., Grotzinger J., Rose-John S., Kallen K. J. 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RT Signals through glycoprotein 130 regulate the endothelial differentiation of cardiac stem cells. RL Arterioscler. Thromb. Vasc. Biol. 29:754-760 (2009). RN [86]; RE0067594. RX PUBMED: 16293640. RA Clarkson R. W., Boland M. P., Kritikou E. A., Lee J. M., Freeman T. C., Tiffen P. G., Watson C. J. RT The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. RL Mol. Endocrinol. 20:675-685 (2006). RN [87]; RE0067754. RX PUBMED: 20051625. RA Walker E. C., McGregor N. E., Poulton I. J., Solano M., Pompolo S., Fernandes T. J., Constable M. J., Nicholson G. C., Zhang J. G., Nicola N. A., Gillespie M. T., Martin T. J., Sims N. A. RT Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice. RL J. Clin. Invest. 120:582-592 (2010). RN [88]; RE0067764. RX PUBMED: 16547273. RA Fritz D. K., Kerr C., Tong L., Smyth D., Richards C. D. RT Oncostatin-M up-regulates VCAM-1 and synergizes with IL-4 in eotaxin expression: involvement of STAT6. RL J. Immunol. 176:4352-4360 (2006). RN [89]; RE0067792. RX PUBMED: 16459330. RA Stross C., Radtke S., Clahsen T., Gerlach C., Volkmer-Engert R., Schaper F., Heinrich P. C., Hermanns H. M. RT Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism. RL J. Biol. Chem. 281:8458-8468 (2006). RN [90]; RE0068007. RX PUBMED: 19651781. RA Wang X., Zhao Q., Matta R., Meng X., Liu X., Liu C. G., Nelin L. D., Liu Y. RT Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1. RL J. Biol. Chem. 284:27123-27134 (2009). RN [91]; RE0068169. RX PUBMED: 19112126. RA Juan T. S., Bolon B., Lindberg R. A., Sun Y., Van G., Fletcher F. A. RT Mice overexpressing murine oncostatin M (OSM) exhibit changes in hematopoietic and other organs that are distinct from those of mice overexpressing human OSM or bovine OSM. RL Vet. Pathol. 46:124-137 (2009). RN [92]; RE0068170. RX PUBMED: 17609432. RA Brender C., Tannahill G. M., Jenkins B. J., Fletcher J., Columbus R., Saris C. J., Ernst M., Nicola N. A., Hilton D. J., Alexander W. S., Starr R. RT Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27. RL Blood 110:2528-2536 (2007). RN [93]; RE0068254. RX PUBMED: 14611646. RA Fischer P., Lehmann U., Sobota R. M., Schmitz J., Niemand C., Linnemann S., Haan S., Behrmann I., Yoshimura A., Johnston J. A., Muller-Newen G., Heinrich P. C., Schaper F. RT The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling. RL Biochem. J. 378:449-460 (2004). RN [94]; RE0068301. RX PUBMED: 9711940. RA Kunisada K., Tone E., Fujio Y., Matsui H., Yamauchi-Takihara K., Kishimoto T. RT Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes. RL Circulation 98:346-352 (1998). RN [95]; RE0068341. RX PUBMED: 20584990. RA Larsen J. V., Hansen M., Moller B., Madsen P., Scheller J., Nielsen M., Petersen C. M. RT Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer. RL Mol. Cell. Biol. 30:4175-4187 (2010). RN [96]; RE0068397. RX PUBMED: 19023034. RA Muller S., Chakrapani B. P., Schwegler H., Hofmann H. D., Kirsch M. RT Neurogenesis in the dentate gyrus depends on ciliary neurotrophic factor and signal transducer and activator of transcription 3 signaling. RL Stem Cells 27:431-441 (2009). RN [97]; RE0068438. RX PUBMED: 16966486. RA Samardzija M., Wenzel A., Aufenberg S., Thiersch M., Reme C., Grimm C. RT Differential role of Jak-STAT signaling in retinal degenerations. RL FASEB J. 20:2411-2413 (2006). RN [98]; RE0068463. RX PUBMED: 20042582. RA Matsumoto S., Hara T., Mitsuyama K., Yamamoto M., Tsuruta O., Sata M., Scheller J., Rose-John S., Kado S., Takada T. RT Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. RL J. Immunol. 184:1543-1551 (2010). RN [99]; RE0068582. RX PUBMED: 15194489. RA Gorogawa S., Fujitani Y., Kaneto H., Hazama Y., Watada H., Miyamoto Y., Takeda K., Akira S., Magnuson M. A., Yamasaki Y., Kajimoto Y., Hori M. RT Insulin secretory defects and impaired islet architecture in pancreatic beta-cell-specific STAT3 knockout mice. RL Biochem. Biophys. Res. Commun. 319:1159-1170 (2004). RN [100]; RE0068797. RX PUBMED: 16616006. RA He F., Stephens J. M. RT Induction of SOCS-3 is insufficient to confer IRS-1 protein degradation in 3T3-L1 adipocytes. RL Biochem. Biophys. Res. Commun. 344:95-98 (2006). RN [101]; RE0069025. RX PUBMED: 19254694. RA Muromoto R., Taira N., Ikeda O., Shiga K., Kamitani S., Togi S., Kawakami S., Sekine Y., Nanbo A., Oritani K., Matsuda T. RT The exon-junction complex proteins, Y14 and MAGOH regulate STAT3 activation. RL Biochem. Biophys. Res. Commun. 382:63-68 (2009). RN [102]; RE0069070. RX PUBMED: 16140268. RA Sato N., Tsuruma R., Imoto S., Sekine Y., Muromoto R., Sugiyama K., Matsuda T. RT Nuclear retention of STAT3 through the coiled-coil domain regulates its activity. RL Biochem. Biophys. Res. Commun. 336:617-624 (2005). RN [103]; RE0069089. RX PUBMED: 15607729. RA Scheller J., Schuster B., Holscher C., Yoshimoto T., Rose-John S. RT No inhibition of IL-27 signaling by soluble gp130. RL Biochem. Biophys. Res. Commun. 326:724-728 (2005). RN [104]; RE0069145. RX PUBMED: 16636663. RA Sekine Y., Tsuji S., Ikeda O., Sato N., Aoki N., Aoyama K., Sugiyama K., Matsuda T. RT Regulation of STAT3-mediated signaling by LMW-DSP2. RL Oncogene 25:5801-5806 (2006). RN [105]; RE0069149. RX PUBMED: 11846786. RA Mellott T., Lopez-Coviella I., Blusztajn J. K., Berse B. RT Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression. RL Eur. J. Biochem. 269:850-858 (2002). RN [106]; RE0069210. RX PUBMED: 8592940. RA Lowe C., Gillespie G. A., Pike J. W. RT Leukemia inhibitory factor as a mediator of JAK/STAT activation in murine osteoblasts. RL J. Bone Miner. Res. 10:1644-1650 (1995). RN [107]; RE0069424. RX PUBMED: 19712053. RA Lin H. W., Levison S. W. RT Context-dependent IL-6 potentiation of interferon- gamma-induced IL-12 secretion and CD40 expression in murine microglia. RL J. Neurochem 111:808-818 (2009). RN [108]; RE0070066. RX PUBMED: 20696842. RA Martin P., Gomez M., Lamana A., Cruz-Adalia A., Ramirez-Huesca M., Ursa M. A., Yanez-Mo M., Sanchez-Madrid F. RT CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation. RL Mol. Cell. Biol. 30:4877-4889 (2010). RN [109]; RE0070088. RX PUBMED: 19818650. RA Gomez-Rodriguez J., Sahu N., Handon R., Davidson T. S., Anderson S. M., Kirby M. R., August A., Schwartzberg P. L. RT Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. RL Immunity 31:587-597 (2009). RN [110]; RE0070879. RX PUBMED: 9582023. RA Chaturvedi P., Reddy M. V., Reddy E. P. RT Src kinases and not JAKs activate STATs during IL-3 induced myeloid cell proliferation. RL Oncogene 16:1749-1758 (1998). RN [111]; RE0070958. RX PUBMED: 21829342. RA Beyer T., Busse M., Hristov K., Gurbiel S., Smida M., Haus U. U., Ballerstein K., Pfeuffer F., Weismantel R., Schraven B., Lindquist J. A. 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