AC T27164
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ID T27164
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DT 12.11.2003 (created); spi.
DT 03.02.2015 (updated); spk.
CO Copyright (C), QIAGEN.
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FA Tip60
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SY 60 kDa Tat interactive protein; cPLA(2) interacting protein; cPLA2; ESA1; HIV-1 Tat interactive protein; HTATIP; HTATIP1; K(lysine) acetyltransferase 5; KAT5; PLIP; TIP; TIP60.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009000 KAT5; HGNC: KAT5.
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CL C0071; C2HC; 2.7.3.0.5.
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IN T08910 Bcl-3; human, Homo sapiens.
IN T10067 c-Krox; human, Homo sapiens.
IN T00137 c-Myb; human, Homo sapiens.
IN T00140 c-Myc-isoform1; human, Homo sapiens.
IN T31295 CBX8; human, Homo sapiens.
IN T01542 E2F-1; human, Homo sapiens.
IN T08297 Kaiso; human, Homo sapiens.
IN T33704 PCGF4; human, Homo sapiens.
IN T01574 STAT3; mouse, Mus musculus.
IN T20157 uhrf1; human, Homo sapiens.
IN T04981 ZNF-24; human, Homo sapiens.
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DR TRANSPATH: MO000037844.
DR UniProtKB: Q92993;
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RN [1]; RE0028144.
RX PUBMED: 10362352.
RA Dechend R., Hirano F., Lehmann K., Heissmeyer V., Ansieau S., Wulczyn F. G., Scheidereit C., Leutz A.
RT The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.
RL Oncogene 18:3316-23 (1999).
RN [2]; RE0029628.
RX PUBMED: 11994312.
RA Gaughan L., Logan I. R., Cook S., Neal D. E., Robson C. N.
RT Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor.
RL J. Biol. Chem. 277:25904-13 (2002).
RN [3]; RE0048055.
RX PUBMED: 15383276.
RA Goehler H., Lalowski M., Stelzl U., Waelter S., Stroedicke M., Worm U., Droege A., Lindenberg K. S., Knoblich M., Haenig C., Herbst M., Suopanki J., Scherzinger E., Abraham C., Bauer B., Hasenbank R., Fritzsche A., Ludewig A. H., Bussow K., Coleman S. H., Gutekunst C. A., Landwehrmeyer B. G., Lehrach H., Wanker E. E.
RT A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
RL Mol. Cell 15:853-865 (2004).
RN [4]; RE0052998.
RX PUBMED: 16705183.
RA Eymin B., Claverie P., Salon C., Leduc C., Col E., Brambilla E., Khochbin S., Gazzeri S.
RT p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress.
RL Mol. Cell. Biol. 26:4339-4350 (2006).
RN [5]; RE0063261.
RX PUBMED: 16169070.
RA Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F. H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., Timm J., Mintzlaff S., Abraham C., Bock N., Kietzmann S., Goedde A., Toksoz E., Droege A., Krobitsch S., Korn B., Birchmeier W., Lehrach H., Wanker E. E.
RT A human protein-protein interaction network: a resource for annotating the proteome.
RL Cell 122:957-968 (2005).
RN [6]; RE0063827.
RX PUBMED: 19308289.
RA Xu L., Chen Y., Song Q., Xu D., Wang Y., Ma D.
RT PDCD5 interacts with Tip60 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis.
RL Neoplasia 11:345-354 (2009).
RN [7]; RE0067198.
RX PUBMED: 16387653.
RA Doyon Y., Cayrou C., Ullah M., Landry A. J., Cote V., Selleck W., Lane W. S., Tan S., Yang X. J., Cote J.
RT ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.
RL Mol. Cell 21:51-64 (2006).
RN [8]; RE0069698.
RX PUBMED: 21045206.
RA Du Z., Song J., Wang Y., Zhao Y., Guda K., Yang S., Kao H. Y., Xu Y., Willis J., Markowitz S. D., Sedwick D., Ewing R. M., Wang Z.
RT DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination.
RL Sci. Signal. 3:ra80 (2010).
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