TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00137 XX ID T00137 XX DT 26.01.1993 (created); hse. DT 29.06.2016 (updated); sup. CO Copyright (C), QIAGEN. XX FA c-Myb XX SY c-Myb; MYB; MYB PROTO-ONCOGENE PROTEIN. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G000220 MYB; HGNC: MYB. XX CL C0022; trp; XX SF C-terminal inhibitory domain, involving the leucine zipper motif which can act on the activating domain in cis and in trans [12] [3]; XX CP hematopoietic system, tumor cell lines; Jurkat [16]. XX FF enhances DNA polymerase alpha expression in T lymphocytes; FF required for G1/S transition [9]; FF expression of the c-myb gene is enhanced by c-Jun and JunD, but not JunB, through an AP-1 element [6]; FF autostimulation of c-myb gene expression through multiple binding sites [4]; XX IN T00048 ATBF1-B; human, Homo sapiens. IN T04106 HDAC1; human, Homo sapiens. IN T25625 hdac2; human, Homo sapiens. IN T18835 Mi2-alpha; human, Homo sapiens. IN T18838 Mi2-BETA; human, Homo sapiens. IN T27164 Tip60; human, Homo sapiens. XX MX M00004 V$CMYB_01. MX M01821 V$CMYB_Q5. MX M00773 V$MYB_Q3. MX M07299 V$MYB_Q4. MX M00913 V$MYB_Q5_01. MX M08890 V$MYB_Q5_02. MX M00183 V$MYB_Q6. XX BS R32837. BS R01098. BS R31097. BS R20700. BS R60154. BS R40862. BS R72874. BS R25384. BS R41357. BS R31128. BS R31131. BS R71216. BS R73993. BS R29667. BS R38716. BS R63879. BS R63882. BS R63883. BS R63884. BS R63885. BS R63886. BS R63599. BS R63890. BS R63891. BS R26922. BS R26923. BS R63887. BS R63889. BS R39196. BS R04082. BS R31140. BS R31141. BS R31218. BS R73794. BS R23912. BS R23914. BS R35416. BS R35421. BS R70543. BS R70544. BS R31179. BS R58911. BS R62280. BS R59156. BS R28489. BS R31109. BS R25847. BS R33925. BS R73867. BS R21711. BS R21712. BS R21713. BS R21714. BS R21719. BS R21723. BS R62519. BS R68630. BS R31170. BS R31171. BS R34946. BS R38136. BS R73986. BS R21801. BS R58919. BS R02206. XX DR TRANSPATH: MO000009619. DR TRANSCOMPEL: C00003. DR TRANSCOMPEL: C00229. DR TRANSCOMPEL: C00230. DR TRANSCOMPEL: C00240. DR UniProtKB: P10242; XX RN [1]; RE0000112. RX PUBMED: 2688896. RA Ness S. A., Marknell A., Graf T. RT The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene RL Cell 59:1115-1125 (1989). RN [2]; RE0000684. RX PUBMED: 2279697. RA Luescher B., Eisenman R. N. RT New light on Myc and Myb. part II. Myb RL Genes Dev. 4:2235-2241 (1990). RN [3]; RE0002237. RX PUBMED: 2189102. RA Kalkbrenner F., Guehmann St., Moelling K. RT Transcriptional activation by human c-myb and v-myb genes RL Oncogene 5:657-661 (1990). RN [4]; RE0002861. RX PUBMED: 1944282. RA Nicolaides N. C., Gualdi R., Casadevall C., Manzella L., Calabretta B. RT Positive autoregulation of c-myb expression via Myb binding sites in the 5 flanking region of the human c-myb gene RL Mol. Cell. Biol. 11:6166-6176 (1991). RN [5]; RE0002952. RX PUBMED: 1465383. RA Sureau A., Soret J., Vellard M., Crochet J., Perbal B. RT The PR264/c-myb connection: Expression of a splicing factor modulated by a nuclear protooncogene RL Proc. Natl. Acad. Sci. USA 89:11683-11687 (1992). RN [6]; RE0003487. RX PUBMED: 1527086. RA Nicolaides N. C., Correa I., Casadevall C., Travali S., Soprano K. J., Calabretta B. RT The jun family members, c- Jun and JunD, transactivate the human c-myb promoter via an Ap1-like element RL J. Biol. Chem. 267:19665-19672 (1992). RN [7]; RE0003553. RX PUBMED: 3014652. RA Slamon D. J., Boone T. C., Murdock D. C., Keith D. E., Press M. F., Larson R. A., Souza L. M. RT Studies of the human c-myb gene and its product in human acute leukemias RL Science 233:347-351 (1986). RN [8]; RE0003554. RX PUBMED: 3540945. RA Majello B., Kenyon L. C., Dalla-Favera R. RT Huamn c-myb protooncogene: Nucleotide sequence of cDNA and organization of the genomic locus RL Proc. Natl. Acad. Sci. USA 83:9636-9640 (1986). RN [9]; RE0003563. RX PUBMED: 1696013. RA Venturelli D., Travali S., Calabretta B. RT Inhibition of T-cell proliferation by a myb antisense oligomer is accompanied by selective down-regulation of DNA polymerase alpha expression RL Proc. Natl. Acad. Sci. USA 87:5963-5967 (1990). RN [10]; RE0003568. RX PUBMED: 2572967. RA Frampton J., Leutz A., Gibson T., Graf T. RT DNA-binding domain ancestry RL Nature 342:134-134 (1989). RN [11]; RE0003573. RX PUBMED: 8420994. RA Ku D.-H., Wen S.-C., Engelhard A., Nicolaides N. C., Lipson K. E., Marino T. A., Calabretta B. RT c-myb transactivates cdc2 expression via myb binding sites in the 5'-flanking region of the human cdc2 gene RL J. Biol. Chem. 268:2255-2259 (1993). RN [12]; RE0003577. RX PUBMED: 8041607. RA Vorbrueggen G., Kalkbrenner F., Guehmann S., Moelling K. RT The carboxyterminus of human c-myb protein stimulates activated transcription in trans RL Nucleic Acids Res. 22:2466-2475 (1994). RN [13]; RE0013449. RX PUBMED: 8643572. RA Melotti P., Calabretta B. RT The transcription factors c-myb and GATA-2 act independently in the regulation of normal hematopoiesis. RL Proc. Natl. Acad. Sci. USA 93:5313-5318 (1996). RN [14]; RE0015127. RX PUBMED: 10318867. RA Kaspar P., Dvorakova M., Kralova J., Pajer P., Kozmik Z., Dvorak M. RT Myb-interacting protein, ATBF1, represses transcriptional activity of Myb oncoprotein RL J. Biol. Chem. 274:14422-14428 (1999). RN [15]; RE0041248. RX PUBMED: 12631292. RA Dahle O., Andersen T. O., Nordgard O., Matre V., Del Sal G., Gabrielsen O. S. RT Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner RL Eur. J. Biochem. 270:1338-48 (2003). RN [16]; RE0050557. RX PUBMED: 12540291. RA Yeung L. H., Read J. T., Sorenson P., Nelson C. C., Jia W., Rennie P. S. RT Identification and characterization of a prostate-specific androgen-independent protein-binding site in the probasin promoter. RL Biochem. J. 371:843-855 (2003). RN [17]; RE0067653. RX PUBMED: 20547751. RA Deisenroth C., Thorner A. R., Enomoto T., Perou C. M., Zhang Y. RT Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53. RL Mol. Cell. Biol. 30:3981-3993 (2010). XX //