AC T00137
XX
ID T00137
XX
DT 26.01.1993 (created); hse.
DT 29.06.2016 (updated); sup.
CO Copyright (C), QIAGEN.
XX
FA c-Myb
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SY c-Myb; MYB; MYB PROTO-ONCOGENE PROTEIN.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G000220 MYB; HGNC: MYB.
XX
CL C0022; trp; 3.5.1.1.1.
XX
SF C-terminal inhibitory domain, involving the leucine zipper motif which can act on the activating domain in cis and in trans [12] [3];
XX
CP hematopoietic system, tumor cell lines; Jurkat [16].
XX
FF enhances DNA polymerase alpha expression in T lymphocytes;
FF required for G1/S transition [9];
FF expression of the c-myb gene is enhanced by c-Jun and JunD, but not JunB, through an AP-1 element [6];
FF autostimulation of c-myb gene expression through multiple binding sites [4];
XX
IN T00048 ATBF1-B; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
IN T25625 hdac2; human, Homo sapiens.
IN T18835 Mi2-alpha; human, Homo sapiens.
IN T18838 Mi2-BETA; human, Homo sapiens.
IN T27164 Tip60; human, Homo sapiens.
XX
MX M00004 V$CMYB_01.
MX M01821 V$CMYB_Q5.
MX M00773 V$MYB_Q3.
MX M07299 V$MYB_Q4.
MX M00913 V$MYB_Q5_01.
MX M08890 V$MYB_Q5_02.
MX M00183 V$MYB_Q6.
XX
BS R32837.
BS R01098.
BS R31097.
BS R20700.
BS R60154.
BS R40862.
BS R72874.
BS R25384.
BS R41357.
BS R31128.
BS R31131.
BS R71216.
BS R73993.
BS R29667.
BS R38716.
BS R63879.
BS R63882.
BS R63883.
BS R63884.
BS R63885.
BS R63886.
BS R63599.
BS R63890.
BS R63891.
BS R26922.
BS R26923.
BS R63887.
BS R63889.
BS R39196.
BS R04082.
BS R31140.
BS R31141.
BS R31218.
BS R73794.
BS R23912.
BS R23914.
BS R35416.
BS R35421.
BS R70543.
BS R70544.
BS R31179.
BS R58911.
BS R62280.
BS R59156.
BS R28489.
BS R31109.
BS R25847.
BS R33925.
BS R73867.
BS R21711.
BS R21712.
BS R21713.
BS R21714.
BS R21719.
BS R21723.
BS R62519.
BS R68630.
BS R31170.
BS R31171.
BS R34946.
BS R38136.
BS R73986.
BS R21801.
BS R58919.
BS R02206.
XX
DR TRANSPATH: MO000009619.
DR TRANSCOMPEL: C00003.
DR TRANSCOMPEL: C00229.
DR TRANSCOMPEL: C00230.
DR TRANSCOMPEL: C00240.
DR UniProtKB: P10242;
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RN [1]; RE0000112.
RX PUBMED: 2688896.
RA Ness S. A., Marknell A., Graf T.
RT The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene
RL Cell 59:1115-1125 (1989).
RN [2]; RE0000684.
RX PUBMED: 2279697.
RA Luescher B., Eisenman R. N.
RT New light on Myc and Myb. part II. Myb
RL Genes Dev. 4:2235-2241 (1990).
RN [3]; RE0002237.
RX PUBMED: 2189102.
RA Kalkbrenner F., Guehmann St., Moelling K.
RT Transcriptional activation by human c-myb and v-myb genes
RL Oncogene 5:657-661 (1990).
RN [4]; RE0002861.
RX PUBMED: 1944282.
RA Nicolaides N. C., Gualdi R., Casadevall C., Manzella L., Calabretta B.
RT Positive autoregulation of c-myb expression via Myb binding sites in the 5 flanking region of the human c-myb gene
RL Mol. Cell. Biol. 11:6166-6176 (1991).
RN [5]; RE0002952.
RX PUBMED: 1465383.
RA Sureau A., Soret J., Vellard M., Crochet J., Perbal B.
RT The PR264/c-myb connection: Expression of a splicing factor modulated by a nuclear protooncogene
RL Proc. Natl. Acad. Sci. USA 89:11683-11687 (1992).
RN [6]; RE0003487.
RX PUBMED: 1527086.
RA Nicolaides N. C., Correa I., Casadevall C., Travali S., Soprano K. J., Calabretta B.
RT The jun family members, c- Jun and JunD, transactivate the human c-myb promoter via an Ap1-like element
RL J. Biol. Chem. 267:19665-19672 (1992).
RN [7]; RE0003553.
RX PUBMED: 3014652.
RA Slamon D. J., Boone T. C., Murdock D. C., Keith D. E., Press M. F., Larson R. A., Souza L. M.
RT Studies of the human c-myb gene and its product in human acute leukemias
RL Science 233:347-351 (1986).
RN [8]; RE0003554.
RX PUBMED: 3540945.
RA Majello B., Kenyon L. C., Dalla-Favera R.
RT Huamn c-myb protooncogene: Nucleotide sequence of cDNA and organization of the genomic locus
RL Proc. Natl. Acad. Sci. USA 83:9636-9640 (1986).
RN [9]; RE0003563.
RX PUBMED: 1696013.
RA Venturelli D., Travali S., Calabretta B.
RT Inhibition of T-cell proliferation by a myb antisense oligomer is accompanied by selective down-regulation of DNA polymerase alpha expression
RL Proc. Natl. Acad. Sci. USA 87:5963-5967 (1990).
RN [10]; RE0003568.
RX PUBMED: 2572967.
RA Frampton J., Leutz A., Gibson T., Graf T.
RT DNA-binding domain ancestry
RL Nature 342:134-134 (1989).
RN [11]; RE0003573.
RX PUBMED: 8420994.
RA Ku D.-H., Wen S.-C., Engelhard A., Nicolaides N. C., Lipson K. E., Marino T. A., Calabretta B.
RT c-myb transactivates cdc2 expression via myb binding sites in the 5'-flanking region of the human cdc2 gene
RL J. Biol. Chem. 268:2255-2259 (1993).
RN [12]; RE0003577.
RX PUBMED: 8041607.
RA Vorbrueggen G., Kalkbrenner F., Guehmann S., Moelling K.
RT The carboxyterminus of human c-myb protein stimulates activated transcription in trans
RL Nucleic Acids Res. 22:2466-2475 (1994).
RN [13]; RE0013449.
RX PUBMED: 8643572.
RA Melotti P., Calabretta B.
RT The transcription factors c-myb and GATA-2 act independently in the regulation of normal hematopoiesis.
RL Proc. Natl. Acad. Sci. USA 93:5313-5318 (1996).
RN [14]; RE0015127.
RX PUBMED: 10318867.
RA Kaspar P., Dvorakova M., Kralova J., Pajer P., Kozmik Z., Dvorak M.
RT Myb-interacting protein, ATBF1, represses transcriptional activity of Myb oncoprotein
RL J. Biol. Chem. 274:14422-14428 (1999).
RN [15]; RE0041248.
RX PUBMED: 12631292.
RA Dahle O., Andersen T. O., Nordgard O., Matre V., Del Sal G., Gabrielsen O. S.
RT Transactivation properties of c-Myb are critically dependent on two SUMO-1 acceptor sites that are conjugated in a PIASy enhanced manner
RL Eur. J. Biochem. 270:1338-48 (2003).
RN [16]; RE0050557.
RX PUBMED: 12540291.
RA Yeung L. H., Read J. T., Sorenson P., Nelson C. C., Jia W., Rennie P. S.
RT Identification and characterization of a prostate-specific androgen-independent protein-binding site in the probasin promoter.
RL Biochem. J. 371:843-855 (2003).
RN [17]; RE0067653.
RX PUBMED: 20547751.
RA Deisenroth C., Thorner A. R., Enomoto T., Perou C. M., Zhang Y.
RT Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53.
RL Mol. Cell. Biol. 30:3981-3993 (2010).
XX
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