AC T00048
XX
ID T00048
XX
DT 10.11.1992 (created); ewi.
DT 06.02.2015 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA ATBF1-B
XX
SY AT motif binding factor 1B; ATBF1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004657 ZFHX3; HGNC: ZFHX3.
XX
HO zfh-2 (Drosophila) T00920.
XX
CL C0006; homeo; 3.1.8.4.2.2.
XX
SZ 2783 AA; 305.7 kDa (cDNA) (calc.).
XX
SQ MRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDMLGLHMNVERSLSED
SQ EWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKEGGKANEWRLKCVAI
SQ GNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESGVEGESCYYHCVLCN
SQ YSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFTIRRCPSTDPEEAIE
SQ DVEGPSETAADPEELAKDQEGGASSSQAEKELTDSPATSKRISFPGSSESPLSSKRPKTA
SQ EEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPLCQDMLNNKIHLQLHLTHL
SQ HSVAPDCVEKLIMTVTTPEMVMPSSMFLPAAVPDRDGNSNLEEAGKQPETSEDLGKNILP
SQ SASTEQSGDLKPSPADPGSVREDSGFICWKKGCNQVFKTSAALQTHFNEVHAKRPQLPVS
SQ DRHVYKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLCQRSFRTFQALKKHLETSHLE
SQ LSEADIQQLYGGLLANGDLLAMGDPTLAEDHTIIVEEDKEEESDLEDKQSPTGSDSGSVQ
SQ EDSGSEPKRALPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNILLVHYNSVSHLHKLK
SQ RALQESATGQPEPTSSPDNKPFKCNTCNVAYSQSSTLEIHMRSVLHQTKARAAKLEAASG
SQ SSNGTGNSSSISLSSSTPSPVSTSGSNTFTTSNPSSAGIAPSSNLLSQVPTESVGMPPLG
SQ NPIGANIASPSEPKEANRKKLADMIASRQQQQQQQQQQQQQQQQQQQAQTLAQAQAQVQA
SQ HLQQELQQQAALIQSQLFNPTLLPHFPMTTETLLQLQQQQHLLFPFYIPSAEFQLNPEVS
SQ LPVTSGALTLTGTGPGLLEDLKAQVQVPQQSHQQILPQQQQNQLSIAQSHSALLQPSQHP
SQ EKKNKLVIKEKEKESQRERDSAEGGEGNTGPKETLPDALKAKEKKELAPGGGSEPSMLPP
SQ RIASDARGNATKALLENFGFELVIQYNENKQKVQKKNGKTDQGENLEKLECDSCGKLFSN
SQ ILILKSHQEHVHQNYFPFKQLERFAKQYRDHYDKLYPLRPQTPEPPPPPPPPPPPPLPAA
SQ PPQPASTPAIPASAPPITSPTIAPAQPSVPLTQLSMPMELPIFSPLMMQTMPLQTLPAQL
SQ PPQLGPVEPLPADLAQLYQHQLNPTLLQQQNKRPRTRITDDQLRVLRQYFDINNSPSEEQ
SQ IKEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITSLEELKIDSRPPSPEPP
SQ KQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLNLPTRVIVVWFQNAR
SQ QKARKNYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLVFQRIFDLIKHQKKLCYKD
SQ EDEEGQDDSQNEDSMDAMEILTPTSSSCSTPMPSQAYSAPAPSANNTASSAFLQLTAEAE
SQ ELATFNSKTEAGDEKPKLAEAPSAQPNQTQEKQGQPKPELQQQEQPEQKTNTPQQKLPQL
SQ VSLPSLPQPPPQAPPPQCPLPQSSPSPSQLSHLPLKPLHTSTPQQLANLPPQLIPYQCDQ
SQ CKLAFPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPSNPLLASQLLSGAIP
SQ QIPASSATSPSTPTSTMNTLKRKLEEKASASPGENDSGTGGEEPQRDKRLRTTITPEQLE
SQ ILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQFRAVGPAQAHRRCP
SQ FCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQMKGDIFDGTSFSHLP
SQ PSSSDGQGVPLSPVSKTMELSPRTLLSPSSIKVEGIEDFESPSMSSVNLNFDQTKLDNDD
SQ CSSVNTAITDTTTGDEGNADNDSATGIATETKSSSAPNEGLTKAAMMAMSEYEDRLSSGL
SQ VSPAPSFYSKEYDNEGTVDYSETSSLADPCSPSPGASGSAGKSGDSGDRPGQKRFRTQMT
SQ NLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAKEKKSKLSMAKHFGI
SQ NQTSYEGPKTECTLCGIKYSARLSVRDHIFSQQHISKVKDTIGSQLDKEKEYFDPATVRQ
SQ LMAQQELDRIKKANEVLGLAAQQQGMFDNTPLQALNLPTAYPALQGIPPVLLPGLNSPSL
SQ PGFTPSNTALTSPKPNLMGLPSTTVPSPGLPTSGLPNKPSSASLSSPTPAQATMAMGPQQ
SQ PPQQQQQQQQPQVQQPPPPPAAQPPPTPQLPLQQQQQRKDKDSEKVKEKEKAHKGKGEPL
SQ PVPKKEKGEAPTATAATISAPLPTMEYAVDPAQLQALQAALTSDPTALLTSQFLPYFVPG
SQ FSPYYAPQIPGALQSGYLQPMYGMEGLFPYSPALSQALMGLSPGSLLQQYQQYQQSLQEA
SQ IQQQQQQKVQQQQPKASQTPVPPGAPSPDKDPAKESPKPEEQKNTPREVSPLLPKLPEEP
SQ EAESKSADSLYDPFIVPKVQYKLVCRKCQAGFSDEEAARSHLKSLCFFGQSVVNLQEMVL
SQ HVPTGGGGGGSGGGGGGGGGGGGGGGGSYHCLACESALCGEEALSQHLESALHKHRTITR
SQ AARNAKEHPSLLPHSACFPDPSTASTSQSAAHSNDSPPPPSAAAPSSASPHASRKSWPQV
SQ VSRASAAKPPSFPPLSSSSTVTSSSCSTSGVQPSMPTDDYSEESDTDLSQKSDGPASPVE
SQ GPKDPSCPKDSGLTSVGTDTFRL
XX
SC translated from EMBL #D10250
XX
FT 67 101 
SM00451; ZnF_U1_5.
FT 70 94 
SM00355; c2h2final6.
FT 126 150 
SM00355; c2h2final6.
FT 171 205 
SM00451; ZnF_U1_5.
FT 174 198 
SM00355; c2h2final6.
FT 309 332 
SM00355; c2h2final6.
FT 338 361 
SM00355; c2h2final6.
FT 446 471 
PF00096; zf-C2H2.
FT 446 471 
SM00355; c2h2final6.
FT 446 476 
PS50157; ZINC_FINGER_C2H2_2.
FT 487 509 PF00096; zf-C2H2.
FT 487 509 PS50157; ZINC_FINGER_C2H2_2.
FT 487 509 SM00355; c2h2final6.
FT 515 538 PF00096; zf-C2H2.
FT 515 538 SM00355; c2h2final6.
FT 628 662 SM00451; ZnF_U1_5.
FT 631 655 PF00096; zf-C2H2.
FT 631 655 SM00355; c2h2final6.
FT 631 662 PS50157; ZINC_FINGER_C2H2_2.
FT 679 713 SM00451; ZnF_U1_5.
FT 682 706 PF00096; zf-C2H2.
FT 682 706 SM00355; c2h2final6.
FT 682 711 PS50157; ZINC_FINGER_C2H2_2.
FT 874 2480 PF00478; IMP dehydrogenase / GMP reductase domain.
FT 937 946 PF00904; Involucrin repeat.
FT 1069 1092 SM00355; c2h2final6.
FT 1069 1097 PS50157; ZINC_FINGER_C2H2_2.
FT 1229 1289 PS50071; HOMEOBOX_2.
FT 1231 1293 SM00389; HOX_1.
FT 1232 1288 PF00046; Homeobox domain.
FT 1326 1386 PS50071; HOMEOBOX_2.
FT 1328 1390 SM00389; HOX_1.
FT 1329 1385 PF00046; Homeobox domain.
FT 1414 1434 SM00355; c2h2final6.
FT 1414 1437 PF00096; zf-C2H2.
FT 1414 1443 PS50157; ZINC_FINGER_C2H2_2.
FT 1616 1638 PF00096; zf-C2H2.
FT 1616 1638 PS50157; ZINC_FINGER_C2H2_2.
FT 1616 1638 SM00355; c2h2final6.
FT 1725 1785 PS50071; HOMEOBOX_2.
FT 1727 1789 SM00389; HOX_1.
FT 1728 1784 PF00046; Homeobox domain.
FT 1797 1820 SM00355; c2h2final6.
FT 1797 1827 PS50157; ZINC_FINGER_C2H2_2.
FT 2030 2090 PS50071; HOMEOBOX_2.
FT 2032 2094 SM00389; HOX_1.
FT 2033 2089 PF00046; Homeobox domain.
FT 2107 2141 SM00451; ZnF_U1_5.
FT 2110 2134 SM00355; c2h2final6.
FT 2311 2320 PF00904; Involucrin repeat.
FT 2460 2469 PF00904; Involucrin repeat.
FT 2484 2520 v-Myb T00895 interaction domain [5].
FT 2543 2563 SM00355; c2h2final6.
FT 2606 2640 SM00451; ZnF_U1_5.
FT 2609 2633 SM00355; c2h2final6.
XX
SF largest DNA-binding protein known to date: 17 zinc finger motifs and 4 homeo domains;
SF proline-rich region, glutamine-rich region, acidic region, serine/threonine-rich region [1];
SF a splice variant is ATBF1-A T01665 [2];
SF retinoic acid induces high expression in P19 cells [2];
XX
CP neuronal cell lines upon differentiation [2]; (cell lines:) caco-2 cells [6] [6] [2].
CN brain (measured in mice) [2].
XX
FF binds to the alpha-fetoprotein (AFP) enhancer [3] [1];
FF repressor of AFP enhancer activity, due to competition (at least in part) between ATBF1 and HNF1 T00368 for the same binding site [3];
FF represses transcriptional activity of v-Myb T00895 oncoprotein [5];
FF may play a role in the development of the mammalian CNS [4];
XX
IN T00137 c-Myb; human, Homo sapiens.
IN T00139 c-Myb; chick, Gallus gallus.
IN T00895 v-Myb; AMV, avian myeloblastosis virus.
XX
BS R09386.
XX
DR TRANSPATH: MO000024666.
DR EMBL: D10250;
DR UniProtKB: Q15911-2;
XX
RN [1]; RE0001649.
RX PUBMED: 1719379.
RA Morinaga T., Yasuda H., Hashimoto T., Higashio K., Tamaoki T.
RT A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers
RL Mol. Cell. Biol. 11:6041-6049 (1991).
RN [2]; RE0003793.
RX PUBMED: 7592926.
RA Miura Y., Tam T., Ido A., Morinaga T., Miki T., Hashimoto T., Tamaoki T.
RT Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner
RL J. Biol. Chem. 270:26840-26848 (1995).
RN [3]; RE0008382.
RX PUBMED: 7507206.
RA Yasuda H., Mizuno A., Tamaoki T., Morinaga T.
RT ATBF1, a multiple-homeodomain zinc finger protein, selectively down-regulates AT-rich elements of the human alpha-fetoprotein gene
RL Mol. Cell. Biol. 14:1395-1401 (1994).
RN [4]; RE0015113.
RX PUBMED: 8654949.
RA Ido A., Miura Y., Watanabe M., Sakai M., Inoue Y., Miki T., Hashimoto T., Morinaga T., Nishi S., Tamaoki T.
RT Cloning of the cDNA encoding the mouse ATBF1 transcription factor
RL Gene 168:227-231 (1996).
RN [5]; RE0015127.
RX PUBMED: 10318867.
RA Kaspar P., Dvorakova M., Kralova J., Pajer P., Kozmik Z., Dvorak M.
RT Myb-interacting protein, ATBF1, represses transcriptional activity of Myb oncoprotein
RL J. Biol. Chem. 274:14422-14428 (1999).
RN [6]; RE0015133.
RX PUBMED: 10623580.
RA Kataoka H., Joh T., Miura Y., Tamaoki T., Senoo K., Ohara H., Nomura T., Tada T., Asai K., Kato T., Itoh M.
RT AT motif binding factor 1-A (ATBF1-A) negatively regulates transcription of the aminopeptidase N gene in the crypt-villus axis of small intestine
RL Biochem. Biophys. Res. Commun. 267:91-95 (2000).
XX
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