AC T01665
XX
ID T01665
XX
DT 08.02.1996 (created); ewi.
DT 06.02.2015 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA ATBF1-A
XX
SY AT motif binding factor 1A.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004657 ZFHX3; HGNC: ZFHX3.
XX
HO zfh-2 (Drosophila) T00920.
XX
CL C0006; homeo; 3.1.8.4.2.1.
XX
SZ 3703 AA; 404.4 kDa (cDNA) (calc.).
XX
SQ MEGCDSPVVSGKDNGCGIPQHQQWTELNSTHLPDKPSSMEQSTGESHGPLDSLRAPFNER
SQ LAESTASAGPPAEPASKEVTCNECSASFASLQTYMEHHCPSARPPPPLREESASDTGEEG
SQ DEESDVENLAGEIVYQPDGSAYIVESLSQLTQGGGACGSGSGSGPLPSLFLNSLPGAGGK
SQ QGDPSCAAPVYPQIINTFHIASSFGKWFEGPDQAFPNTSALAGLSPVLHSFRVFDVRHKS
SQ NKDYLNSDGSAKSSCVSKDVPNNVDLSKFDGFVLYGKRKPILMCFLCKLSFGYVRSFVTH
SQ AVHDHRMTLSEDERKILSNKNISAIIQGIGKDKEPLVSFLEPKNKNFQHPLVSTANLIGP
SQ GHSFYGKFSGIRMEGEEALPAGSAAGPEQPQAGLLTPSTLLNLGGLTSSVLKTPITSVPL
SQ GALASSPTKSSEGKDSGAAEGEKQEVGDGDCFSEKVEPAEEEAEEEEEEEEAEEEEEEEE
SQ EEEEEEEDEGCKGLFPSELDEELEDRPHEEPGAAAGSSSKKDLALSNQSISNSPLMPNVL
SQ QTLSRGTASTSSNSASSFVVFDGANRRNRLSFNSEGVRTNVAEGGRRLDFADESANKDNA
SQ TAPEPNESTEGDDGGFVPHHQHAGSLCELGVGECPSGSGVECPKCDTVLGSSRSLGGHMT
SQ MMHSRNSCKTLKCPKCNWHYKYQQTLEAHMKEKHPEPGGSCVYCKSGQPHPRLARGESYT
SQ CGYKPFRCEVCNYSTTTKGNLSIHMQSDKHLNNMQNLQNGGGEQVFIHTAGAAAAAAAAA
SQ AAAANISSSCGAPSPTKPKTKPTWRCEVCDYETNVARNLRIHMTSEKHMHNMMLLQQNMT
SQ QIQHNHHRVLGSLPSPAEAELYQYYLAQNMNLPNLKMDSAASDAQFMMSGFQLDPAGPMA
SQ AMTPALVGGEIPLDMRLGGGQLVSEELMNLGESFIQTNDPSLKLFQCAVCNKFTTDNLDM
SQ LGLHMNVERSLSEDEWKAVMGDSYQCKLCRYNTQLKANFQLHCKTDKHVQKYQLVAHIKE
SQ GGKANEWRLKCVAIGNPVHLKCNACDYYTNSLEKLRLHTVNSRHEASLKLYKHLQQHESG
SQ VEGESCYYHCVLCNYSTKAKLNLIQHVRSMKHQRSESLRKLQRLQKGLPEEDEDLGQIFT
SQ IRRCPSTDPEEAIEDVEGPSETAADPEELAKDQEGGASSSQAEKELTDSPATSKRISFPG
SQ SSESPLSSKRPKTAEEIKPEQMYQCPYCKYSNADVNRLRVHAMTQHSVQPMLRCPLCQDM
SQ LNNKIHLQLHLTHLHSVAPDCVEKLIMTVTTPEMVMPSSMFLPAAVPDRDGNSNLEEAGK
SQ QPETSEDLGKNILPSASTEQSGDLKPSPADPGSVREDSGFICWKKGCNQVFKTSAALQTH
SQ FNEVHAKRPQLPVSDRHVYKYRCNQCSLAFKTIEKLQLHSQYHVIRAATMCCLCQRSFRT
SQ FQALKKHLETSHLELSEADIQQLYGGLLANGDLLAMGDPTLAEDHTIIVEEDKEEESDLE
SQ DKQSPTGSDSGSVQEDSGSEPKRALPFRKGPNFTMEKFLDPSRPYKCTVCKESFTQKNIL
SQ LVHYNSVSHLHKLKRALQESATGQPEPTSSPDNKPFKCNTCNVAYSQSSTLEIHMRSVLH
SQ QTKARAAKLEAASGSSNGTGNSSSISLSSSTPSPVSTSGSNTFTTSNPSSAGIAPSSNLL
SQ SQVPTESVGMPPLGNPIGANIASPSEPKEANRKKLADMIASRQQQQQQQQQQQQQQQQQQ
SQ QAQTLAQAQAQVQAHLQQELQQQAALIQSQLFNPTLLPHFPMTTETLLQLQQQQHLLFPF
SQ YIPSAEFQLNPEVSLPVTSGALTLTGTGPGLLEDLKAQVQVPQQSHQQILPQQQQNQLSI
SQ AQSHSALLQPSQHPEKKNKLVIKEKEKESQRERDSAEGGEGNTGPKETLPDALKAKEKKE
SQ LAPGGGSEPSMLPPRIASDARGNATKALLENFGFELVIQYNENKQKVQKKNGKTDQGENL
SQ EKLECDSCGKLFSNILILKSHQEHVHQNYFPFKQLERFAKQYRDHYDKLYPLRPQTPEPP
SQ PPPPPPPPPPLPAAPPQPASTPAIPASAPPITSPTIAPAQPSVPLTQLSMPMELPIFSPL
SQ MMQTMPLQTLPAQLPPQLGPVEPLPADLAQLYQHQLNPTLLQQQNKRPRTRITDDQLRVL
SQ RQYFDINNSPSEEQIKEMADKSGLPQKVIKHWFRNTLFKERQRNKDSPYNFSNPPITSLE
SQ ELKIDSRPPSPEPPKQEYWGSKRSSRTRFTDYQLRVLQDFFDANAYPKDDEFEQLSNLLN
SQ LPTRVIVVWFQNARQKARKNYENQGEGKDGERRELTNDRYIRTSNLNYQCKKCSLVFQRI
SQ FDLIKHQKKLCYKDEDEEGQDDSQNEDSMDAMEILTPTSSSCSTPMPSQAYSAPAPSANN
SQ TASSAFLQLTAEAEELATFNSKTEAGDEKPKLAEAPSAQPNQTQEKQGQPKPELQQQEQP
SQ EQKTNTPQQKLPQLVSLPSLPQPPPQAPPPQCPLPQSSPSPSQLSHLPLKPLHTSTPQQL
SQ ANLPPQLIPYQCDQCKLAFPSFEHWQEHQQLHFLSAQNQFIHPQFLDRSLDMPFMLFDPS
SQ NPLLASQLLSGAIPQIPASSATSPSTPTSTMNTLKRKLEEKASASPGENDSGTGGEEPQR
SQ DKRLRTTITPEQLEILYQKYLLDSNPTRKMLDHIAHEVGLKKRVVQVWFQNTRARERKGQ
SQ FRAVGPAQAHRRCPFCRALFKAKTALEAHIRSRHWHEAKRAGYNLTLSAMLLDCDGGLQM
SQ KGDIFDGTSFSHLPPSSSDGQGVPLSPVSKTMELSPRTLLSPSSIKVEGIEDFESPSMSS
SQ VNLNFDQTKLDNDDCSSVNTAITDTTTGDEGNADNDSATGIATETKSSSAPNEGLTKAAM
SQ MAMSEYEDRLSSGLVSPAPSFYSKEYDNEGTVDYSETSSLADPCSPSPGASGSAGKSGDS
SQ GDRPGQKRFRTQMTNLQLKVLKSCFNDYRTPTMLECEVLGNDIGLPKRVVQVWFQNARAK
SQ EKKSKLSMAKHFGINQTSYEGPKTECTLCGIKYSARLSVRDHIFSQQHISKVKDTIGSQL
SQ DKEKEYFDPATVRQLMAQQELDRIKKANEVLGLAAQQQGMFDNTPLQALNLPTAYPALQG
SQ IPPVLLPGLNSPSLPGFTPSNTALTSPKPNLMGLPSTTVPSPGLPTSGLPNKPSSASLSS
SQ PTPAQATMAMGPQQPPQQQQQQQQPQVQQPPPPPAAQPPPTPQLPLQQQQQRKDKDSEKV
SQ KEKEKAHKGKGEPLPVPKKEKGEAPTATAATISAPLPTMEYAVDPAQLQALQAALTSDPT
SQ ALLTSQFLPYFVPGFSPYYAPQIPGALQSGYLQPMYGMEGLFPYSPALSQALMGLSPGSL
SQ LQQYQQYQQSLQEAIQQQQQRQLQQQQQQKVQQQQPKASQTPVPPGAPSPDKDPAKESPK
SQ PEEQKNTPREVSPLLPKLPEEPEAESKSADSLYDPFIVPKVQYKLVCRKCQAGFSDEEAA
SQ RSHLKSLCFFGQSVVNLQEMVLHVPTGGGGGGSGGGGGGGGGGGGGGSYHCLACESALCG
SQ EEALSQHLESALHKHRTITRAARNAKEHPSLLPHSACFPDPSTASTSQSAAHSNDSPPPP
SQ SAAAPSSASPHASRKSWPQVVSRASAAKPPSFPPLSSSSTVTSSSCSTSGVQPSMPTDDY
SQ SEESDTDLSQKSDGPASPVEGPKDPSCPKDSGLTSVGTDTFRL
XX
SC translated from EMBL #L32832
XX
FT 79 98 
SM00355; c2h2final6.
FT 282 305 
SM00355; c2h2final6.
FT 640 663 
SM00355; c2h2final6.
FT 671 694 
PF00096; zf-C2H2.
FT 671 694 
SM00355; c2h2final6.
FT 723 757 
SM00451; ZnF_U1_5.
FT 726 750 
PF00096; zf-C2H2.
FT 726 750 
SM00355; c2h2final6.
FT 726 755 
PS50157; ZINC_FINGER_C2H2_2.
FT 804 828 
PF00096; zf-C2H2.
FT 804 828 SM00355; c2h2final6.
FT 835 844 PF00904; Involucrin repeat.
FT 981 1015 SM00451; ZnF_U1_5.
FT 984 1008 SM00355; c2h2final6.
FT 1040 1064 SM00355; c2h2final6.
FT 1085 1119 SM00451; ZnF_U1_5.
FT 1088 1112 SM00355; c2h2final6.
FT 1223 1246 SM00355; c2h2final6.
FT 1252 1275 SM00355; c2h2final6.
FT 1360 1385 PF00096; zf-C2H2.
FT 1360 1385 SM00355; c2h2final6.
FT 1360 1390 PS50157; ZINC_FINGER_C2H2_2.
FT 1401 1423 PF00096; zf-C2H2.
FT 1401 1423 PS50157; ZINC_FINGER_C2H2_2.
FT 1401 1423 SM00355; c2h2final6.
FT 1429 1452 PF00096; zf-C2H2.
FT 1429 1452 SM00355; c2h2final6.
FT 1542 1576 SM00451; ZnF_U1_5.
FT 1545 1569 PF00096; zf-C2H2.
FT 1545 1569 SM00355; c2h2final6.
FT 1545 1576 PS50157; ZINC_FINGER_C2H2_2.
FT 1593 1627 SM00451; ZnF_U1_5.
FT 1596 1620 PF00096; zf-C2H2.
FT 1596 1620 SM00355; c2h2final6.
FT 1596 1625 PS50157; ZINC_FINGER_C2H2_2.
FT 1788 3397 PF00478; IMP dehydrogenase / GMP reductase domain.
FT 1851 1860 PF00904; Involucrin repeat.
FT 1983 2006 SM00355; c2h2final6.
FT 1983 2011 PS50157; ZINC_FINGER_C2H2_2.
FT 2143 2203 PS50071; HOMEOBOX_2.
FT 2145 2207 SM00389; HOX_1.
FT 2146 2202 PF00046; Homeobox domain.
FT 2240 2300 PS50071; HOMEOBOX_2.
FT 2242 2304 SM00389; HOX_1.
FT 2243 2299 PF00046; Homeobox domain.
FT 2328 2348 SM00355; c2h2final6.
FT 2328 2351 PF00096; zf-C2H2.
FT 2328 2357 PS50157; ZINC_FINGER_C2H2_2.
FT 2530 2552 PF00096; zf-C2H2.
FT 2530 2552 PS50157; ZINC_FINGER_C2H2_2.
FT 2530 2552 SM00355; c2h2final6.
FT 2639 2699 PS50071; HOMEOBOX_2.
FT 2641 2703 SM00389; HOX_1.
FT 2642 2698 PF00046; Homeobox domain.
FT 2711 2734 SM00355; c2h2final6.
FT 2711 2741 PS50157; ZINC_FINGER_C2H2_2.
FT 2944 3004 PS50071; HOMEOBOX_2.
FT 2946 3008 SM00389; HOX_1.
FT 2947 3003 PF00046; Homeobox domain.
FT 3021 3055 SM00451; ZnF_U1_5.
FT 3024 3048 SM00355; c2h2final6.
FT 3225 3234 PF00904; Involucrin repeat.
FT 3465 3485 SM00355; c2h2final6.
FT 3526 3560 SM00451; ZnF_U1_5.
FT 3529 3553 SM00355; c2h2final6.
XX
SF 23 zinc finger motifs and 4 homeo domains;
SF a splice variant generated by alternative promoter usage is ATBF1-B T00048 [1];
SF the N-terminal extension is encoded by another exon [1];
SF retinoic acid induces high expression in P19 cells [1];
XX
CP neuronal cell lines upon differentiation, (embryonal and newborn mice:) brain [1]; (cell lines:) caco-2 cells [3] [3] [1].
XX
FF may play a role in the development of the mammalian CNS [2];
FF suppressor of APN (aminopeptidase N) transcription [3];
XX
BS R09388.
XX
DR TRANSPATH: MO000025850.
DR EMBL: L32832;
DR EMBL: L32833;
DR UniProtKB: Q15911-1;
XX
RN [1]; RE0003793.
RX PUBMED: 7592926.
RA Miura Y., Tam T., Ido A., Morinaga T., Miki T., Hashimoto T., Tamaoki T.
RT Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner
RL J. Biol. Chem. 270:26840-26848 (1995).
RN [2]; RE0015113.
RX PUBMED: 8654949.
RA Ido A., Miura Y., Watanabe M., Sakai M., Inoue Y., Miki T., Hashimoto T., Morinaga T., Nishi S., Tamaoki T.
RT Cloning of the cDNA encoding the mouse ATBF1 transcription factor
RL Gene 168:227-231 (1996).
RN [3]; RE0015133.
RX PUBMED: 10623580.
RA Kataoka H., Joh T., Miura Y., Tamaoki T., Senoo K., Ohara H., Nomura T., Tada T., Asai K., Kato T., Itoh M.
RT AT motif binding factor 1-A (ATBF1-A) negatively regulates transcription of the aminopeptidase N gene in the crypt-villus axis of small intestine
RL Biochem. Biophys. Res. Commun. 267:91-95 (2000).
XX
//