AC T00368
XX
ID T00368
XX
DT 15.10.1992 (created); ewi.
DT 07.02.2007 (updated); sts.
CO Copyright (C), QIAGEN.
XX
FA HNF-1alpha-A
XX
SY APF; Hepatocyte Nuclear Factor 1alpha; HNF-1; HNF-1A; HNF-1alpha; HNF1; LF-B1; TCF-1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004661 HNF1A; HGNC: HNF1A.
XX
CL C0007; POU; 3.1.10.7.1.1.
XX
SZ 631 AA; 67.4 kDa (cDNA) (calc.), 92 kDa (SDS)
XX
SQ MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAEL
SQ PNGLGETRGSEDETDDDGEDFTPPILKELENLSPEEAAHQKAVVETLLQEDPWRVAKMVK
SQ SYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA
SQ GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAE
SQ CIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALP
SQ AHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSH
SQ SLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPA
SQ SLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPV
SQ QSHVTQSPFMATMAQLQSPHALYSHKPEVAQYTHTGLLPQTMLITDTTNLSALASLTPTK
SQ QVFTSDTEASSESGLHTPASQATTLHVPSQDPAGIQHLQPAHRLSASPTVSSSSLVLYQS
SQ SDSSNGQSHLLPSNHSVIETFISTQMASSSQ
XX
SC Swiss-Prot#P20823, Tyr-322 taken from Ref. [5]
XX
FT 1 176 
PF04814; Hepatocyte nuclear factor 1 (HNF-1), N termi.
FT 118 556 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 197 278 
PS50071; HOMEOBOX_2.
FT 199 282 
SM00389; HOX_1.
FT 208 219 
helix 1 [4].
FT 226 240 
helix 2 [4].
FT 261 274 
helix 3 [4].
FT 282 541 
PF04812; Hepatocyte nuclear factor 1 (HNF-1), beta is.
FT 438 631 
replaced by 438-494 in HNF-1alpha-C [5].
FT 501 631 
replaced by 501-542 in HNF-1alpha-B [5].
FT 542 631 PF04813; Hepatocyte nuclear factor 1 (HNF-1), alpha i.
XX
SF usage of an alternative poly(A) signal leads to HNF-1alpha-B, whereas an unspliced intron introduces a new stop codon giving rise to HNF-1alpha-C [5];
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CP liver, intestine, spleen, stomach, kidney; cell lines (Caco cells) [7].
CN cell lines (Colo-DM cells) [7].
XX
FF activator [5];
FF synergistic interaction with C/EBPalpha [6];
FF activator of some intestine-specific promoters [8] [7];
XX
IN T01950 HNF-1alpha-B; human, Homo sapiens.
IN T01951 HNF-1alpha-C; human, Homo sapiens.
IN T00889 HNF-1beta; rat, Rattus norvegicus.
IN T00890 HNF-1beta; mouse, Mus musculus.
XX
MX M07044 V$HNF1A_Q4.
MX M02013 V$HNF1A_Q5.
MX M00132 V$HNF1_01.
MX M01379 V$HNF1_02.
MX M00206 V$HNF1_C.
MX M00790 V$HNF1_Q6.
MX M01011 V$HNF1_Q6_01.
XX
BS R01913.
BS R01807.
BS R02174.
BS R04717.
BS R13038.
BS R00077.
BS R03260.
BS R03666.
BS R14713.
BS R00237.
BS R00238.
BS R15909.
BS R04122.
BS R04474.
BS R08083.
BS R57167.
BS R17191.
BS R17192.
BS R13051.
BS R02910.
BS R03302.
BS R03305.
BS R15363.
BS R04237.
BS R04238.
BS R73049.
BS R17072.
BS R18913.
BS R18909.
BS R18912.
BS R14722.
BS R14761.
BS R14764.
BS R02970.
BS R03485.
BS R12712.
BS R12711.
BS R01625.
BS R00431.
BS R15848.
BS R15849.
BS R08491.
XX
DR TRANSPATH: MO000024883.
DR TRANSCOMPEL: C00051.
DR TRANSCOMPEL: C00095.
DR TRANSCOMPEL: C00281.
DR TRANSCOMPEL: C00286.
DR TRANSCOMPEL: C00368.
DR TRANSCOMPEL: C00417.
DR PATHODB: MT010535.
DR PATHODB: MT010536.
DR PATHODB: MT010537.
DR PATHODB: MT010538.
DR PATHODB: MT010539.
DR PATHODB: MT010540.
DR PATHODB: MT010541.
DR PATHODB: MT010542.
DR PATHODB: MT010543.
DR PATHODB: MT010544.
DR PATHODB: MT010872.
DR PATHODB: MT010873.
DR PATHODB: MT010874.
DR PATHODB: MT010875.
DR PATHODB: MT010876.
DR PATHODB: MT010877.
DR PATHODB: MT010878.
DR PATHODB: MT010884.
DR PATHODB: MT010885.
DR PATHODB: MT010886.
DR EMBL: M57732;
DR UniProtKB: P20823-1;
XX
RN [1]; RE0000321.
RX PUBMED: 3262058.
RA Monaci P., Nicosia A., Cortese R.
RT Two different liver-specific factors stimulate in vitro transcription from the human alpha1-antitrypsin promoter
RL EMBO J. 7:2075-2087 (1988).
RN [2]; RE0000632.
RX PUBMED: 3063603.
RA Williams T., Admon A., Luescher B., Tjian R.
RT Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements
RL Genes Dev. 2:1557-1569 (1988).
RN [3]; RE0001405.
RX PUBMED: 2479822.
RA Feuerman M. H., Godbout R., Ingram R. S., Tilghman S. M.
RT Tissue-Specific Transcription of the Mouse alpha-Fetoprotein Gene Promoter Is Dependent of HNF-1
RL Mol. Cell. Biol. 9:4204-4212 (1989).
RN [4]; RE0004697.
RX PUBMED: 8491172.
RA Leiting B., de Francesco R., Tomei L., Cortese R., Otting G., Whthrich K.
RT The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a non-classical homeodomain
RL EMBO J. 12:1797-1803 (1993).
RN [5]; RE0004699.
RX PUBMED: 7900999.
RA Bach I., Yaniv M.
RT More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing
RL EMBO J. 12:4229-4242 (1993).
RN [6]; RE0006229.
RX PUBMED: 8288579.
RA Wu K.-J., Wilson D. R., Shih C., Darlington G. J.
RT The transcription factor HNF1 acts with C/EBPalpha to synergistically activate the human albumin promoter through a novel domain
RL J. Biol. Chem. 269:1177-1182 (1994).
RN [7]; RE0009286.
RX PUBMED: 8006012.
RA Wu G. D., Chen L., Forslund K., Traber P. G.
RT Hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta regulate transcription via two elements in an intestine-specific promoter
RL J. Biol. Chem. 269:17080-17085 (1994).
RN [8]; RE0014376.
RX PUBMED: 7908650.
RA Olsen J., Laustsen L., Troelsen J.
RT HNF1 alpha activates the aminopeptidase N promoter in intestinal (Caco-2) cells
RL FEBS Lett. 342:325-328 (1994).
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