AC T00889
AS T00468.
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ID T00889
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DT 15.10.1992 (created); ewi.
DT 22.01.2016 (updated); smt.
CO Copyright (C), QIAGEN.
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FA HNF-1beta
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SY hepatocyte nuclear factors 2; HNF-1B; LF-A1; LF-B3 (mouse); TCF-2; vHNF-1; vHNF1.
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OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G013739 Hnf1b.
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HO NF-BA1.
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CL C0007; POU; 3.1.10.7.2.
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CP (liver).
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FF activator, may modulate the activity of HNF-1 [12];
FF predominantly found in dedifferentiated hepatoma cells [4];
FF expressed in several endodermal and mesodermal embryonal tissues before HNF-1 [14];
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IN T00368 HNF-1alpha-A; human, Homo sapiens.
IN T00369 HNF-1alpha; rat, Rattus norvegicus.
IN T01211 HNF-1alpha; mouse, Mus musculus.
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MX M01425 V$HNF1B_01.
MX M03826 V$HNF1B_Q6.
MX M03872 V$HNF1B_Q6_01.
MX M00790 V$HNF1_Q6.
MX M01011 V$HNF1_Q6_01.
MX M00646 V$LFA1_Q6.
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BS R71542.
BS R00114.
BS R00115.
BS R00116.
BS R00118.
BS R21077.
BS R02192.
BS R17145.
BS R00099.
BS R00438.
BS R35849.
BS R25806.
BS R25808.
BS R25886.
BS R25889.
BS R02175.
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DR TRANSPATH: MO000045337.
DR TRANSCOMPEL: C00602.
DR UniProtKB: P23899;
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RN [1]; RE0000320.
RX PUBMED: 2844524.
RA Hardon E. M., Frain M., Paonessa G., Cortese R.
RT Two distinct factors interact with the promoter regions of several liver-specific genes
RL EMBO J. 7:1711-1719 (1988).
RN [2]; RE0000321.
RX PUBMED: 3262058.
RA Monaci P., Nicosia A., Cortese R.
RT Two different liver-specific factors stimulate in vitro transcription from the human alpha1-antitrypsin promoter
RL EMBO J. 7:2075-2087 (1988).
RN [3]; RE0000341.
RX PUBMED: 2847919.
RA Baumhueter S., Courtois G., Crabtree G. R.
RT A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the beta fibrinogen gene promoter as HNF-1
RL EMBO J. 7:2485-2493 (1988).
RN [4]; RE0000454.
RX PUBMED: 2357969.
RA Cereghini S., Yaniv M., Cortese R.
RT Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1
RL EMBO J. 9:2257-2263 (1990).
RN [5]; RE0000457.
RX PUBMED: 1673926.
RA Rey-Campos J., Chouard T., Yaniv M., Cereghini S.
RT vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1
RL EMBO J. 10:1445-1457 (1991).
RN [6]; RE0000675.
RX PUBMED: 2044952.
RA Mendel D. B., Hansen L. P., Graves M. K., Conley P. B., Crabtree G. R.
RT HNF-1alpha and HNF-1beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro
RL Genes Dev. 5:1042-1056 (1991).
RN [7]; RE0000921.
RX PUBMED: 2341408.
RA Rangan V. S., Das G. C.
RT Purification and Biochemical Characterization of Hepatocyte Nuclear Factor 2 Involved in Liver-specific Transcription of the Human alpha1-Antitrypsin Gene
RL J. Biol. Chem. 265:8874-8879 (1990).
RN [8]; RE0000971.
RX PUBMED: 1900840.
RA Papazafiri P., Ogami K., Ramji D. P., Nicosia A., Monaci P., Cladaras C., Zannis V. I.
RT Promoter elements and factors involved in hepatic transcription of the human ApoA-I gene positive and negative regulators bind to overlapping sites
RL J. Biol. Chem. 266:5790-5797 (1991).
RN [9]; RE0001221.
RX PUBMED: 3263567.
RA Li Y., Shen R.-F., Tsai S. Y., Woo S. L. C.
RT Multiple Hepatic trans-Acting Factors Are Required for In Vitro Transcription of the Human Alpha-1-Antitrypsin Gene
RL Mol. Cell. Biol. 8:4362-4369 (1988).
RN [10]; RE0001961.
RX PUBMED: 2495523.
RA Lucero M. A., Sanchez D., Ochoa A. R., Brunel F., Cohen G. N., Baralle F. E., Zakin M. M.
RT Interaction of DNA-binding proteins with the tissue-specific human apolipoprotein-AII enhancer
RL Nucleic Acids Res. 17:2283-2300 (1989).
RN [11]; RE0002093.
RX PUBMED: 2020548.
RA Ramji D. P., Tadros M. H., Hardon E. M., Cortese R.
RT The transcription factor LF-A1 interacts with a bipartite recognition sequence in the promoter regions of several liver-specific genes
RL Nucleic Acids Res. 19:1139-1146 (1991).
RN [12]; RE0004698.
RX PUBMED: 7678342.
RA Babajko S., Tronch J. F., Groyer A.
RT Liver-specific expression of human insulin-like growth factor binding protein 1: Functional role of transcription factor HNF1 in vivo
RL Proc. Natl. Acad. Sci. USA 90:272-276 (1993).
RN [13]; RE0004755.
RX PUBMED: 8388098.
RA Menoud P.-A., Matthies R., Hofsteenge J., Nagamine Y.
RT Purification and cDNA cloning of a transcription factor which functionally cooperates within a cAMP regulatory unit in the porcine uPA gene
RL Nucleic Acids Res. 21:1845-1852 (1993).
RN [14]; RE0004756.
RX PUBMED: 1685890.
RA Ott M.-O., Rey-Campos J., Cereghini S., Yaniv M.
RT vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression
RL Mech. Dev. 36:47-58 (1991).
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