TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00889 AS T00468. XX ID T00889 XX DT 15.10.1992 (created); ewi. DT 22.01.2016 (updated); smt. CO Copyright (C), QIAGEN. XX FA HNF-1beta XX SY hepatocyte nuclear factors 2; HNF-1B; LF-A1; LF-B3 (mouse); TCF-2; vHNF-1; vHNF1. XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G013739 Hnf1b. XX HO NF-BA1. XX CL C0007; POU; XX CP (liver). XX FF activator, may modulate the activity of HNF-1 [12]; FF predominantly found in dedifferentiated hepatoma cells [4]; FF expressed in several endodermal and mesodermal embryonal tissues before HNF-1 [14]; XX IN T00368 HNF-1alpha-A; human, Homo sapiens. IN T00369 HNF-1alpha; rat, Rattus norvegicus. IN T01211 HNF-1alpha; mouse, Mus musculus. XX MX M01425 V$HNF1B_01. MX M03826 V$HNF1B_Q6. MX M03872 V$HNF1B_Q6_01. MX M00790 V$HNF1_Q6. MX M01011 V$HNF1_Q6_01. MX M00646 V$LFA1_Q6. XX BS R71542. BS R00114. BS R00115. BS R00116. BS R00118. BS R21077. BS R02192. BS R17145. BS R00099. BS R00438. BS R35849. BS R25806. BS R25808. BS R25886. BS R25889. BS R02175. XX DR TRANSPATH: MO000045337. DR TRANSCOMPEL: C00602. DR UniProtKB: P23899; XX RN [1]; RE0000320. RX PUBMED: 2844524. RA Hardon E. M., Frain M., Paonessa G., Cortese R. RT Two distinct factors interact with the promoter regions of several liver-specific genes RL EMBO J. 7:1711-1719 (1988). RN [2]; RE0000321. RX PUBMED: 3262058. RA Monaci P., Nicosia A., Cortese R. RT Two different liver-specific factors stimulate in vitro transcription from the human alpha1-antitrypsin promoter RL EMBO J. 7:2075-2087 (1988). RN [3]; RE0000341. RX PUBMED: 2847919. RA Baumhueter S., Courtois G., Crabtree G. R. RT A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the beta fibrinogen gene promoter as HNF-1 RL EMBO J. 7:2485-2493 (1988). RN [4]; RE0000454. RX PUBMED: 2357969. RA Cereghini S., Yaniv M., Cortese R. RT Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1 RL EMBO J. 9:2257-2263 (1990). RN [5]; RE0000457. RX PUBMED: 1673926. RA Rey-Campos J., Chouard T., Yaniv M., Cereghini S. RT vHNF1 is a homeoprotein that activates transcription and forms heterodimers with HNF1 RL EMBO J. 10:1445-1457 (1991). RN [6]; RE0000675. RX PUBMED: 2044952. RA Mendel D. B., Hansen L. P., Graves M. K., Conley P. B., Crabtree G. R. RT HNF-1alpha and HNF-1beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro RL Genes Dev. 5:1042-1056 (1991). RN [7]; RE0000921. RX PUBMED: 2341408. RA Rangan V. S., Das G. C. RT Purification and Biochemical Characterization of Hepatocyte Nuclear Factor 2 Involved in Liver-specific Transcription of the Human alpha1-Antitrypsin Gene RL J. Biol. Chem. 265:8874-8879 (1990). RN [8]; RE0000971. RX PUBMED: 1900840. RA Papazafiri P., Ogami K., Ramji D. P., Nicosia A., Monaci P., Cladaras C., Zannis V. I. RT Promoter elements and factors involved in hepatic transcription of the human ApoA-I gene positive and negative regulators bind to overlapping sites RL J. Biol. Chem. 266:5790-5797 (1991). RN [9]; RE0001221. RX PUBMED: 3263567. RA Li Y., Shen R.-F., Tsai S. Y., Woo S. L. C. RT Multiple Hepatic trans-Acting Factors Are Required for In Vitro Transcription of the Human Alpha-1-Antitrypsin Gene RL Mol. Cell. Biol. 8:4362-4369 (1988). RN [10]; RE0001961. RX PUBMED: 2495523. RA Lucero M. A., Sanchez D., Ochoa A. R., Brunel F., Cohen G. N., Baralle F. E., Zakin M. M. RT Interaction of DNA-binding proteins with the tissue-specific human apolipoprotein-AII enhancer RL Nucleic Acids Res. 17:2283-2300 (1989). RN [11]; RE0002093. RX PUBMED: 2020548. RA Ramji D. P., Tadros M. H., Hardon E. M., Cortese R. RT The transcription factor LF-A1 interacts with a bipartite recognition sequence in the promoter regions of several liver-specific genes RL Nucleic Acids Res. 19:1139-1146 (1991). RN [12]; RE0004698. RX PUBMED: 7678342. RA Babajko S., Tronch J. F., Groyer A. RT Liver-specific expression of human insulin-like growth factor binding protein 1: Functional role of transcription factor HNF1 in vivo RL Proc. Natl. Acad. Sci. USA 90:272-276 (1993). RN [13]; RE0004755. RX PUBMED: 8388098. RA Menoud P.-A., Matthies R., Hofsteenge J., Nagamine Y. RT Purification and cDNA cloning of a transcription factor which functionally cooperates within a cAMP regulatory unit in the porcine uPA gene RL Nucleic Acids Res. 21:1845-1852 (1993). RN [14]; RE0004756. RX PUBMED: 1685890. RA Ott M.-O., Rey-Campos J., Cereghini S., Yaniv M. RT vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression RL Mech. Dev. 36:47-58 (1991). XX //