TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01211 XX ID T01211 XX DT 15.10.1992 (created); ewi. DT 01.12.2014 (updated); pro. CO Copyright (C), QIAGEN. XX FA HNF-1alpha XX SY APF; Hepatocyte Nuclear Factor 1alpha; HNF-1A; HNF1; LF-B1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G013737 Hnf1a. XX CL C0007; POU; XX SF glycosylation; SF similar factor in lung: 110 + 120 kDa (SDS); SF dimerizes in the absence of DNA [2]; SF unusual for homeobox genes, gene regions encoding helix 2 and 3 are separated by an intron [9]; XX CP liver, intestine, spleen, stomach, kidney. CN lung. XX FF induced in F9 cells by RA, plateau after 5d [1]; XX IN T00889 HNF-1beta; rat, Rattus norvegicus. IN T00890 HNF-1beta; mouse, Mus musculus. XX MX M02013 V$HNF1A_Q5. MX M00132 V$HNF1_01. MX M01379 V$HNF1_02. MX M00206 V$HNF1_C. MX M00790 V$HNF1_Q6. MX M01011 V$HNF1_Q6_01. MX M02815 V$TCF1_06. MX M02919 V$TCF1_07. XX BS R06970. BS R06971. BS R06972. BS R06973. BS R06974. BS R06975. BS R06976. BS R06977. BS R06978. BS R06979. BS R06980. BS R06981. BS R06982. BS R06983. BS R06984. BS R06985. BS R06986. BS R06987. BS R06988. BS R06989. BS R06990. BS R06991. BS R06992. BS R06993. BS R06994. BS R06995. BS R74047. BS R02174. BS R04717. BS R27148. BS R13053. BS R20966. BS R71086. BS R74024. BS R14649. BS R21077. BS R21078. BS R04019. BS R38855. BS R32185. BS R62835. BS R33016. BS R38096. BS R38099. BS R38100. BS R40124. BS R40127. BS R65106. BS R21010. BS R21013. BS R40461. BS R56847. BS R28267. BS R62810. BS R62834. BS R00439. BS R72324. BS R21329. XX DR TRANSPATH: MO000045335. DR TRANSCOMPEL: C00282. DR TRANSCOMPEL: C00303. DR TRANSCOMPEL: C00624. DR TRANSCOMPEL: C00625. DR TRANSCOMPEL: C00626. DR TRANSCOMPEL: C00627. DR TRANSCOMPEL: C00628. DR UniProtKB: P22361; XX RN [1]; RE0000510. RX PUBMED: 2065662. RA Kuo C. J., Mendel D. B., Hansen L. P., Crabtree G. R. RT Independent regulation of HNF-1alpha and HNF-1beta by retinoic acid in F9 teratocarcinoma cells RL EMBO J. 10:2231-2236 (1991). RN [2]; RE0000675. RX PUBMED: 2044952. RA Mendel D. B., Hansen L. P., Graves M. K., Conley P. B., Crabtree G. R. RT HNF-1alpha and HNF-1beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro RL Genes Dev. 5:1042-1056 (1991). RN [3]; RE0001365. RX PUBMED: 1694011. RA Abraham L. J., Bradshaw A. D., Shiels B. R., Northemann W., Hudson G., Fey G. H. RT Hepatic Transcription of the Acute-Phase alpha1-Inhibitor III Gene Is Controlled by a Novel Combination of cis-Acting Regulatory Elements RL Mol. Cell. Biol. 10:3483-3491 (1990). RN [4]; RE0001386. RX PUBMED: 2601716. RA Chang H.-K., Wang B.-Y., Yuh C.-H., Wei C.-L., Ting L.-P. RT A Liver-Specific Nuclear Factor Interacts with the Promoter Region of the Large Surface Protein Gene of Human Hepatitis B Virus RL Mol. Cell. Biol. 9:5189-5197 (1989). RN [5]; RE0001392. RX PUBMED: 2601701. RA Tsutsumi K.-I., Ito K., Ishikawa K. RT Developmental Appearance of Transcription Factors That Regulate Liver-Specific Expression of the Aldolase B Gene RL Mol. Cell. Biol. 9:4923-4931 (1989). RN [6]; RE0001582. RX PUBMED: 1990282. RA Liu J.-K., DiPersio C. M., Zaret K. S. RT Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro RL Mol. Cell. Biol. 11:773-784 (1991). RN [7]; RE0002415. RX PUBMED: 2263635. RA Kuo C. J., Conley P. B., Hsieh C.-L., Francke U., Crabtree S. RT Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1 RL Proc. Natl. Acad. Sci. USA 87:9838-9842 (1990). RN [8]; RE0002595. RX PUBMED: 3499668. RA Courtois G., Morgan J. G., Campbell L. A., Fourel G., Crabtree G. R. RT Interaction of a liver-specific nuclear factor with the fibrinogen and alpha1-antitrypsin promoters RL Science 238:688-692 (1987). RN [9]; RE0004692. RX PUBMED: 1354855. RA Bach I., Pontoglio M., Yaniv M. RT Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1) RL Nucleic Acids Res. 20:4199-4204 (1992). RN [10]; RE0004693. RX PUBMED: 1734282. RA Kuo C. J., Conley P. B., Chen L., Sladek F. M., Darnell J. E., Crabtree G. R. RT A transcriptional hierarchy involved in mammalian cell-type specification RL Nature 355:457-461 (1992). RN [11]; RE0004697. RX PUBMED: 8491172. RA Leiting B., de Francesco R., Tomei L., Cortese R., Otting G., Whthrich K. RT The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a non-classical homeodomain RL EMBO J. 12:1797-1803 (1993). RN [12]; RE0067673. RX PUBMED: 17855651. RA Kikuchi R., Kusuhara H., Hattori N., Kim I., Shiota K., Gonzalez F. J., Sugiyama Y. RT Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation. RL Mol. Pharmacol. 72:1619-1625 (2007). XX //