AC T01211
XX
ID T01211
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DT 15.10.1992 (created); ewi.
DT 01.12.2014 (updated); pro.
CO Copyright (C), QIAGEN.
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FA HNF-1alpha
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SY APF; Hepatocyte Nuclear Factor 1alpha; HNF-1A; HNF1; LF-B1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G013737 Hnf1a.
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CL C0007; POU; 3.1.10.7.1.
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SF glycosylation;
SF similar factor in lung: 110 + 120 kDa (SDS);
SF dimerizes in the absence of DNA [2];
SF unusual for homeobox genes, gene regions encoding helix 2 and 3 are separated by an intron [9];
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CP liver, intestine, spleen, stomach, kidney.
CN lung.
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FF induced in F9 cells by RA, plateau after 5d [1];
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IN T00889 HNF-1beta; rat, Rattus norvegicus.
IN T00890 HNF-1beta; mouse, Mus musculus.
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MX M02013 V$HNF1A_Q5.
MX M00132 V$HNF1_01.
MX M01379 V$HNF1_02.
MX M00206 V$HNF1_C.
MX M00790 V$HNF1_Q6.
MX M01011 V$HNF1_Q6_01.
MX M02815 V$TCF1_06.
MX M02919 V$TCF1_07.
XX
BS R06970.
BS R06971.
BS R06972.
BS R06973.
BS R06974.
BS R06975.
BS R06976.
BS R06977.
BS R06978.
BS R06979.
BS R06980.
BS R06981.
BS R06982.
BS R06983.
BS R06984.
BS R06985.
BS R06986.
BS R06987.
BS R06988.
BS R06989.
BS R06990.
BS R06991.
BS R06992.
BS R06993.
BS R06994.
BS R06995.
BS R74047.
BS R02174.
BS R04717.
BS R27148.
BS R13053.
BS R20966.
BS R71086.
BS R74024.
BS R14649.
BS R21077.
BS R21078.
BS R04019.
BS R38855.
BS R32185.
BS R62835.
BS R33016.
BS R38096.
BS R38099.
BS R38100.
BS R40124.
BS R40127.
BS R65106.
BS R21010.
BS R21013.
BS R40461.
BS R56847.
BS R28267.
BS R62810.
BS R62834.
BS R00439.
BS R72324.
BS R21329.
XX
DR TRANSPATH: MO000045335.
DR TRANSCOMPEL: C00282.
DR TRANSCOMPEL: C00303.
DR TRANSCOMPEL: C00624.
DR TRANSCOMPEL: C00625.
DR TRANSCOMPEL: C00626.
DR TRANSCOMPEL: C00627.
DR TRANSCOMPEL: C00628.
DR UniProtKB: P22361;
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RN [1]; RE0000510.
RX PUBMED: 2065662.
RA Kuo C. J., Mendel D. B., Hansen L. P., Crabtree G. R.
RT Independent regulation of HNF-1alpha and HNF-1beta by retinoic acid in F9 teratocarcinoma cells
RL EMBO J. 10:2231-2236 (1991).
RN [2]; RE0000675.
RX PUBMED: 2044952.
RA Mendel D. B., Hansen L. P., Graves M. K., Conley P. B., Crabtree G. R.
RT HNF-1alpha and HNF-1beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro
RL Genes Dev. 5:1042-1056 (1991).
RN [3]; RE0001365.
RX PUBMED: 1694011.
RA Abraham L. J., Bradshaw A. D., Shiels B. R., Northemann W., Hudson G., Fey G. H.
RT Hepatic Transcription of the Acute-Phase alpha1-Inhibitor III Gene Is Controlled by a Novel Combination of cis-Acting Regulatory Elements
RL Mol. Cell. Biol. 10:3483-3491 (1990).
RN [4]; RE0001386.
RX PUBMED: 2601716.
RA Chang H.-K., Wang B.-Y., Yuh C.-H., Wei C.-L., Ting L.-P.
RT A Liver-Specific Nuclear Factor Interacts with the Promoter Region of the Large Surface Protein Gene of Human Hepatitis B Virus
RL Mol. Cell. Biol. 9:5189-5197 (1989).
RN [5]; RE0001392.
RX PUBMED: 2601701.
RA Tsutsumi K.-I., Ito K., Ishikawa K.
RT Developmental Appearance of Transcription Factors That Regulate Liver-Specific Expression of the Aldolase B Gene
RL Mol. Cell. Biol. 9:4923-4931 (1989).
RN [6]; RE0001582.
RX PUBMED: 1990282.
RA Liu J.-K., DiPersio C. M., Zaret K. S.
RT Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro
RL Mol. Cell. Biol. 11:773-784 (1991).
RN [7]; RE0002415.
RX PUBMED: 2263635.
RA Kuo C. J., Conley P. B., Hsieh C.-L., Francke U., Crabtree S.
RT Molecular cloning, functional expression, and chromosomal localization of mouse hepatocyte nuclear factor 1
RL Proc. Natl. Acad. Sci. USA 87:9838-9842 (1990).
RN [8]; RE0002595.
RX PUBMED: 3499668.
RA Courtois G., Morgan J. G., Campbell L. A., Fourel G., Crabtree G. R.
RT Interaction of a liver-specific nuclear factor with the fibrinogen and alpha1-antitrypsin promoters
RL Science 238:688-692 (1987).
RN [9]; RE0004692.
RX PUBMED: 1354855.
RA Bach I., Pontoglio M., Yaniv M.
RT Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1)
RL Nucleic Acids Res. 20:4199-4204 (1992).
RN [10]; RE0004693.
RX PUBMED: 1734282.
RA Kuo C. J., Conley P. B., Chen L., Sladek F. M., Darnell J. E., Crabtree G. R.
RT A transcriptional hierarchy involved in mammalian cell-type specification
RL Nature 355:457-461 (1992).
RN [11]; RE0004697.
RX PUBMED: 8491172.
RA Leiting B., de Francesco R., Tomei L., Cortese R., Otting G., Whthrich K.
RT The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a non-classical homeodomain
RL EMBO J. 12:1797-1803 (1993).
RN [12]; RE0067673.
RX PUBMED: 17855651.
RA Kikuchi R., Kusuhara H., Hattori N., Kim I., Shiota K., Gonzalez F. J., Sugiyama Y.
RT Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation.
RL Mol. Pharmacol. 72:1619-1625 (2007).
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