TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00369 XX ID T00369 XX DT 15.10.1992 (created); ewi. DT 01.10.2014 (updated); hna. CO Copyright (C), QIAGEN. XX FA HNF-1alpha XX SY APF; Hepatocyte Nuclear Factor 1alpha; HNF1; HNF1A; LF-B1. XX OS rat, Rattus norvegicus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G000756 Hnf1a. XX CL C0007; POU; XX SF tripartite DNA-binding domain comprising the POUs homology region extended towards the N-terminus (pos. 113), the homeo domain, and the dimerization domain [19]; SF dimerization domain comprises a kinked alpha helix (7-18 and 23-32), both helices in a parallel orientation within the dimer [19] [22]; SF dimerization constant > 10E+8/mol [23]; SF instead of the usual 3 AA, there is a long loop of 21 residues between helices 2 and 3, which both are encoded by different exons [24]; SF of the homeo domain, helix 3 contacts the major groove of the DNA, the loop is irregularly folded, and helix 2 is extended by one extra helical turn [27] [28]; SF dimer docking to the DNA requires either bending of the DNA or rearrangement of the peptide monomers within the dimer [27]; SF the homeo domain is sufficient for monomeric DNA-binding, the POUs is auxiliary in mediating full affinity and specificity [26]; SF may be glycosylated; SF a similar factor in lung has 110 + 120 kDa (SDS); XX CP liver, intestine, spleen, stomach, kidney [8]. CN brain, heart, lung, skin, thymus [8], spleen [17] [17] [8]. XX FF activator [1] [6]; FF may act synergistically when bound to two distant sites [6]; FF involved in hepatocyte-specific gene expression, although not being the sole determinant [17] [8]; FF cooperates with other liver-enriched factors such as C/EBP, HNF-3, HNF-4 [17]; FF expressed in hepatocytes only after differentiation, its gene being regulated by other liver-enriched factors such as HNF-4 [9] [25] [5]; FF down-regulates its own expression by an indirect mechanism, but dependent on an intact NF-1 DNA-binding domain an a C-terminal region different from ADI [31]; FF dimerization is facilitated by cofactor DCoH, two molecules of which interact with an HNF-1 dimer thus stabilizing it and augmenting transcription activation [21]; FF HNF-1 activity may be modulated by HNF-1beta (vHNF-1) [29]; XX IN T00889 HNF-1beta; rat, Rattus norvegicus. IN T00890 HNF-1beta; mouse, Mus musculus. IN T08191 NF-1C; rat, Rattus norvegicus. XX MX M02013 V$HNF1A_Q5. MX M00132 V$HNF1_01. MX M01379 V$HNF1_02. MX M00206 V$HNF1_C. MX M00790 V$HNF1_Q6. MX M01011 V$HNF1_Q6_01. XX BS R02174. BS R04717. BS R00118. BS R00120. BS R00121. BS R00123. BS R64198. BS R64199. BS R12423. BS R00081. BS R35356. BS R04122. BS R04123. BS R13051. BS R13053. BS R21045. BS R20966. BS R71086. BS R71073. BS R74020. BS R21077. BS R02045. BS R00091. BS R17145. BS R33016. BS R00432. BS R00436. BS R00099. BS R01800. BS R15848. BS R15849. BS R13269. BS R02780. BS R36172. BS R35849. BS R21329. BS R39329. BS R19432. BS R23503. BS R25886. BS R25889. BS R34465. BS R21051. BS R18920. BS R02895. XX DR TRANSPATH: MO000045336. DR TRANSCOMPEL: C00279. DR TRANSCOMPEL: C00280. DR TRANSCOMPEL: C00581. DR UniProtKB: P15257; DR PDB: 1lfb. XX RN [1]; RE0000042. RX PUBMED: 2571419. RA Frain M., Swart G., Monaci P., Nicosia A., Staempfli S., Frank R., Cortese R. RT The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain RL Cell 59:145-157 (1989). RN [2]; RE0000151. RX PUBMED: 2736625. RA Lichtsteiner S., Schibler U. RT A Glycosylated Liver-Specific Transcription Factor Stimulates Transcription of the Albumin Gene RL Cell 57:1179-1187 (1989). RN [3]; RE0000320. RX PUBMED: 2844524. RA Hardon E. M., Frain M., Paonessa G., Cortese R. RT Two distinct factors interact with the promoter regions of several liver-specific genes RL EMBO J. 7:1711-1719 (1988). RN [4]; RE0000341. RX PUBMED: 2847919. RA Baumhueter S., Courtois G., Crabtree G. R. RT A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the beta fibrinogen gene promoter as HNF-1 RL EMBO J. 7:2485-2493 (1988). RN [5]; RE0000454. RX PUBMED: 2357969. RA Cereghini S., Yaniv M., Cortese R. RT Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1 RL EMBO J. 9:2257-2263 (1990). RN [6]; RE0000455. RX PUBMED: 2265613. RA Toniatti C., Demartis A., Monaci P., Nicosia A., Ciliberto G. RT Synergistic trans-activation of the human C-reactive protein promoter by transcription factor HNF-1 binding at two distinct sites RL EMBO J. 9:4467-4475 (1990). RN [7]; RE0000456. RX PUBMED: 1673925. RA de Simone V., de Magistris L., Lazzaro D., Gerstner J., Monaci P., Nicosia A., Cortese R. RT LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is expressed in specialized epithelia RL EMBO J. 10:1435-1443 (1991). RN [8]; RE0000600. RX PUBMED: 1970973. RA Baumhueter S., Mendel D. B., Conley P. B., Kuo C. J., Turk C., Graves M. K., Edwards C. A., Courtois G., Crabtree G. R. RT HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF RL Genes Dev. 4:372-379 (1990). RN [9]; RE0000786. RX PUBMED: 1748280. RA Tian J.-M., Schibler U. RT Tissue-specific expression of the gene encoding hepatocyte nuclear factor 1 may involve hepatocyte nuclear factor 4 RL Genes Dev. 5:2225-2234 (1991). RN [10]; RE0000834. RX PUBMED: 2455718. RA Jose-Estanyol M., Danan J.-L. RT A Liver-Specific Factor and Nuclear Factor I Bind to the Rat alpha-Fetoprotein Promoter RL J. Biol. Chem. 263:10865-10871 (1988). RN [11]; RE0001004. RX PUBMED: 1904868. RA Chambaz J., Cardot P., Pastier D., Zannis V. I., Cladaras C. RT Promoter elements and factors required for hepatic transcription of the human apoA-II gene RL J. Biol. Chem. 266:11676-11685 (1991). RN [12]; RE0001221. RX PUBMED: 3263567. RA Li Y., Shen R.-F., Tsai S. Y., Woo S. L. C. RT Multiple Hepatic trans-Acting Factors Are Required for In Vitro Transcription of the Human Alpha-1-Antitrypsin Gene RL Mol. Cell. Biol. 8:4362-4369 (1988). RN [13]; RE0001365. RX PUBMED: 1694011. RA Abraham L. J., Bradshaw A. D., Shiels B. R., Northemann W., Hudson G., Fey G. H. RT Hepatic Transcription of the Acute-Phase alpha1-Inhibitor III Gene Is Controlled by a Novel Combination of cis-Acting Regulatory Elements RL Mol. Cell. Biol. 10:3483-3491 (1990). RN [14]; RE0001386. RX PUBMED: 2601716. RA Chang H.-K., Wang B.-Y., Yuh C.-H., Wei C.-L., Ting L.-P. RT A Liver-Specific Nuclear Factor Interacts with the Promoter Region of the Large Surface Protein Gene of Human Hepatitis B Virus RL Mol. Cell. Biol. 9:5189-5197 (1989). RN [15]; RE0001392. RX PUBMED: 2601701. RA Tsutsumi K.-I., Ito K., Ishikawa K. RT Developmental Appearance of Transcription Factors That Regulate Liver-Specific Expression of the Aldolase B Gene RL Mol. Cell. Biol. 9:4923-4931 (1989). RN [16]; RE0001554. RX PUBMED: 2388615. RA Ueno T., Gonzalez F. J. RT Transcriptional control of the rat hepatic CYP2E1 gene RL Mol. Cell. Biol. 10:4495-4505 (1990). RN [17]; RE0002544. RX PUBMED: 2023930. RA Xanthopoulos K. G., Prezioso V. R., Chen W. S., Sladek F. M., Cortese R., Darnell jr J. E. RT The different tissue trancription patterns of genes for HNF-1, C/EBP, HNF-3 and HNF-4, protein factors that govern liver-specific transcription RL Proc. Natl. Acad. Sci. USA 88:3807-3811 (1991). RN [18]; RE0002595. RX PUBMED: 3499668. RA Courtois G., Morgan J. G., Campbell L. A., Fourel G., Crabtree G. R. RT Interaction of a liver-specific nuclear factor with the fibrinogen and alpha1-antitrypsin promoters RL Science 238:688-692 (1987). RN [19]; RE0004687. RX PUBMED: 2364427. RA Nicosia A., Monaci P., Tomei L., de Francesco R., Nuzzo M., Stunnenberg H., Cortese R. RT A myosin-like dimerization helix and an extra-large homeodomain are essential elements of the tripartite DNA binding structure of LFB1 RL Cell 61:1225-1236 (1990). RN [20]; RE0004688. RX PUBMED: 2460858. RA Courtois G., Baumhueter S., Crabtree G. R. RT Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters RL Proc. Natl. Acad. Sci. USA 85:7937-7941 (1988). RN [21]; RE0004689. RX PUBMED: 1763325. RA Mendel D. B., Khavari P. A., Conley P. B., Graves M. K., Hansen L. P., Admon A., Crabtree G. R. RT Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein RL Science 254:1762-1767 (1991). RN [22]; RE0004690. RX PUBMED: 1988016. RA Pastore A., de Francesco R., Barbato G., Castiglione Morelli M. A., Motta A., Cortese R. RT 1H Resonance assigment and secondary structure determination of the dimerization domain of transcription factor LFB1 RL Biochemistry 30:148-153 (1991). RN [23]; RE0004691. RX PUBMED: 1988015. RA de Francesco R., Pastore A., Vecchio G., Cortese R. RT Circular dichroism study on the conformational stability of the dimerization domain of transcription factor LFB1 RL Biochemistry 30:143-147 (1991). RN [24]; RE0004692. RX PUBMED: 1354855. RA Bach I., Pontoglio M., Yaniv M. RT Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1) RL Nucleic Acids Res. 20:4199-4204 (1992). RN [25]; RE0004693. RX PUBMED: 1734282. RA Kuo C. J., Conley P. B., Chen L., Sladek F. M., Darnell J. E., Crabtree G. R. RT A transcriptional hierarchy involved in mammalian cell-type specification RL Nature 355:457-461 (1992). RN [26]; RE0004694. RX PUBMED: 1356766. RA Tomei L., Cortese R., de Francesco R. RT A POU-A related region dictates DNA binding specificity of LFB1/HNF1 by orienting the two XL-homeodomains in the dimer RL EMBO J. 11:4119-4129 (1992). RN [27]; RE0004696. RX PUBMED: 8491173. RA Ceska T. A., Lamers M., Monaci P., Nicosia A., Cortese R., Suck D. RT The X-ray structure of an atypical homeodomain present in the rat liver transcription factorLFB1/HNF1 and implications for DNA binding RL EMBO J. 12:1805-1810 (1993). RN [28]; RE0004697. RX PUBMED: 8491172. RA Leiting B., de Francesco R., Tomei L., Cortese R., Otting G., Whthrich K. RT The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a non-classical homeodomain RL EMBO J. 12:1797-1803 (1993). RN [29]; RE0004698. RX PUBMED: 7678342. RA Babajko S., Tronch J. F., Groyer A. RT Liver-specific expression of human insulin-like growth factor binding protein 1: Functional role of transcription factor HNF1 in vivo RL Proc. Natl. Acad. Sci. USA 90:272-276 (1993). RN [30]; RE0004700. RX PUBMED: 1465414. RA Citron B. A., Davis M. D., Milstien S., Gutierrez J., Mendel D. B., Crabtree G. R., Kaufman S. RT Identity of 4a-carbinolamine dehydratase, a component of the phenylalanine hydroxylation system, and DCoH, a transregulator of homeodomain proteins RL Proc. Natl. Acad. Sci. USA 89:11891-11894 (1992). RN [31]; RE0004702. RX PUBMED: 7937157. RA Piaggio G., Tomei L., Toniatti C., de Francesco R., Gerstner J., Cortese R. RT LFB1/HNF1 acts as a repressor of its own transcription RL Nucleic Acids Res. 22:4284-4290 (1994). RN [32]; RE0004703. RX PUBMED: 2216777. RA Chouard T., Blumenfeld M., Bach I., Vandekerckhove J., Cereghini S., Yaniv M. RT A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain RL Nucleic Acids Res. 18:5853-5863 (1990). RN [33]; RE0004704. RX PUBMED: 1967225. RA Finney M. RT The homeodomain of the transcription factor LF-B1 has a 21 amino acid loop between helix 2 and helix 3 RL Cell 60:5-6 (1990). XX //