AC T01950
XX
ID T01950
XX
DT 19.11.1996 (created); ewi.
DT 07.03.2012 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA HNF-1alpha-B
XX
SY HNF-1A; HNF-1alpha; HNF1; LFB1; TCF1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004661 HNF1A; HGNC: HNF1A.
XX
CL C0007; POU; 3.1.10.7.1.2.
XX
SZ 542 AA; 57.9 kDa (cDNA) (calc.).
XX
SQ MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAEL
SQ PNGLGETRGSEDETDDDGEDFTPPILKELENLSPEEAAHQKAVVETLLQEDPWRVAKMVK
SQ SYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA
SQ GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAE
SQ CIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALP
SQ AHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSH
SQ SLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPA
SQ SLGPTFTNTGASTLVIGLASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPV
SQ QSHVTQSPFMATMAQLQSPHGEHPVPHTAGDDDRGWLSMDAGERGAWQALQSACVSGTSV
SQ FP
XX
SC Swiss-Prot#P20823 and edited; Tyr-322 according to Ref. [2]
XX
FT 1 176 
PF04814; Hepatocyte nuclear factor 1 (HNF-1), N termi.
FT 118 541 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 197 278 
PS50071; HOMEOBOX_2.
FT 199 282 
SM00389; HOX_1.
FT 208 219 
helix 1 [1].
FT 226 240 
helix 2 [1].
FT 261 274 
helix 3 [1].
FT 282 535 
PF04812; Hepatocyte nuclear factor 1 (HNF-1), beta is.
FT 438 542 
replaced by 438-494 in HNF-1alpha-C [2].
FT 501 542 
replaced by 501-631 in HNF-1alpha-A [2].
XX
SF usage of an alternative poly(A) signal leads to HNF-1alpha-A, whereas an unspliced intron introduces a new stop codon giving rise to HNF-1alpha-C [2];
XX
FF activator, 5-fold more potent than HNF-1alpha-A [2];
XX
IN T00368 HNF-1alpha-A; human, Homo sapiens.
IN T01951 HNF-1alpha-C; human, Homo sapiens.
XX
MX M02162 V$HNF1A_01.
MX M02013 V$HNF1A_Q5.
MX M00132 V$HNF1_01.
MX M01379 V$HNF1_02.
MX M00206 V$HNF1_C.
MX M00790 V$HNF1_Q6.
MX M01011 V$HNF1_Q6_01.
XX
BS R01913.
BS R01807.
BS R02174.
BS R00077.
BS R03260.
BS R03666.
BS R00237.
BS R00238.
BS R02910.
BS R03302.
BS R03305.
BS R18909.
BS R02970.
BS R01625.
BS R00431.
XX
DR TRANSPATH: MO000026046.
DR EMBL: X71346;
DR UniProtKB: P20823-2;
XX
RN [1]; RE0004697.
RX PUBMED: 8491172.
RA Leiting B., de Francesco R., Tomei L., Cortese R., Otting G., Whthrich K.
RT The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a non-classical homeodomain
RL EMBO J. 12:1797-1803 (1993).
RN [2]; RE0004699.
RX PUBMED: 7900999.
RA Bach I., Yaniv M.
RT More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing
RL EMBO J. 12:4229-4242 (1993).
XX
//