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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T01951 XX ID T01951 XX DT 19.11.1996 (created); ewi. DT 07.03.2012 (updated); mkl. CO Copyright (C), QIAGEN. XX FA HNF-1alpha-C XX SY HNF-1A; HNF-1alpha; HNF1; LFB1; TCF1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G004661 HNF1A; HGNC: HNF1A. XX CL C0007; POU; 3.1.10.7.1.3. XX SZ 494 AA; 52.8 kDa (cDNA) (calc.). XX SQ MVSKLSQLQTELLAALLESGLSKEALIQALGEPGPYLLAGEGPLDKGESCGGGRGELAEL SQ PNGLGETRGSEDETDDDGEDFTPPILKELENLSPEEAAHQKAVVETLLQEDPWRVAKMVK SQ SYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVRKQREVAQQFTHA SQ GQGGLIEEPTGDELPTKKGRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNRAE SQ CIQRGVSPSQAQGLGSNLVTEVRVYNWFANRRKEEAFRHKLAMDTYSGPPPGPGPGPALP SQ AHSSPGLPPPALSPSKVHGVRYGQPATSETAEVPSSSGGPLVTVSTPLHQVSPTGLEPSH SQ SLLSTEAKLVSAAGGPLPPVSTLTALHSLEQTSPGLNQQPQNLIMASLPGVMTIGPGEPA SQ SLGPTFTNTGASTLVIGKLVGMGGHLGGRLMGQPQNPGAGRATGTHSFIHSFIQHVFIQC SQ LLWTSHCATSVIPG XX SC Swiss-Prot#P20823 and edited; Tyr-322 according to Ref. [2] XX FT 1 176 PF04814; Hepatocyte nuclear factor 1 (HNF-1), N termi. FT 197 278 PS50071; HOMEOBOX_2. FT 199 282 SM00389; HOX_1. FT 208 219 helix 1 [1]. FT 226 240 helix 2 [1]. FT 261 274 helix 3 [1]. FT 282 493 PF04812; Hepatocyte nuclear factor 1 (HNF-1), beta is. FT 438 494 replaced by 438-631 in HNF-1alpha-A [2]. XX SF usage of an alternative poly(A) signal leads to HNF-1alpha-A [2]; XX FF activator, 5-fold more potent than HNF-1alpha-A [2]; FF mRNA levels are about 4-11% of HNF-1alpha-A mRNA except fetal and adult kidney (86% and 27%, resp.) [2]; XX IN T00368 HNF-1alpha-A; human, Homo sapiens. IN T01950 HNF-1alpha-B; human, Homo sapiens. XX MX M02162 V$HNF1A_01. MX M02013 V$HNF1A_Q5. MX M00132 V$HNF1_01. MX M01379 V$HNF1_02. MX M00206 V$HNF1_C. MX M00790 V$HNF1_Q6. MX M01011 V$HNF1_Q6_01. XX BS R01913. BS R01807. BS R02174. BS R00077. BS R03260. BS R03666. BS R00237. BS R00238. BS R02910. BS R03302. BS R03305. BS R02970. BS R01625. BS R00431. XX DR TRANSPATH: MO000026047. DR EMBL: X71347; DR UniProtKB: P20823-3; XX RN [1]; RE0004697. RX PUBMED: 8491172. RA Leiting B., de Francesco R., Tomei L., Cortese R., Otting G., Whthrich K. RT The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a non-classical homeodomain RL EMBO J. 12:1797-1803 (1993). RN [2]; RE0004699. RX PUBMED: 7900999. RA Bach I., Yaniv M. RT More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing RL EMBO J. 12:4229-4242 (1993). XX //