AC T01580
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ID T01580
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DT 24.11.1995 (created); ewi.
DT 14.09.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA STAT6
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SY Signal Transducer and Activator of Transcription 1; signal transducer and activator of transcription 6; Stat-6.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001089 STAT6; HGNC: STAT6.
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CL C0039; STAT; 6.2.1.0.7.
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CP hemopoietic cell lines (mainly) [1]; B-CLL and B-Lymphocytes [10].
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FF mediates promoter activation of TARC/CCL17 by IL4 stimulation [6];
FF mediates response to IL-3 and IL-4 (which induce tyrosine phosphorylation) [1];
FF no induction by IL-2, IL-12, erythropoietin [1];
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IN T01318 CBP; mouse, Mus musculus.
IN T01427 p300; human, Homo sapiens.
IN T08171 PSF; human, Homo sapiens.
IN T04639 SRC-1; mouse, Mus musculus.
XX
MX M00494 V$STAT6_01.
MX M00500 V$STAT6_02.
MX M07066 V$STAT6_Q4.
MX M00223 V$STAT_01.
MX M00777 V$STAT_Q6.
XX
BS R24227.
BS R30603.
BS R68191.
BS R68197.
BS R13321.
BS R33462.
BS R71290.
BS R62461.
BS R57384.
BS R57387.
BS R57389.
BS R57391.
BS R62605.
BS R32883.
BS R19526.
BS R19527.
BS R61729.
BS R29822.
BS R24094.
BS R11115.
BS R11183.
BS R30133.
BS R35847.
BS R35848.
BS R41568.
BS R33498.
BS R33499.
BS R60503.
BS R60504.
BS R60650.
BS R69714.
BS R69715.
BS R23774.
BS R66267.
BS R66268.
BS R25470.
BS R25471.
BS R64633.
BS R29824.
BS R55969.
BS R41564.
BS R37809.
BS R19668.
BS R25447.
BS R74048.
BS R29233.
BS R29236.
BS R62306.
BS R62307.
BS R27186.
BS R27188.
BS R27191.
BS R34735.
BS R33282.
BS R33284.
BS R33285.
BS R33286.
BS R26945.
BS R04650.
XX
DR TRANSPATH: MO000031956.
DR TRANSCOMPEL: C00306.
DR TRANSCOMPEL: C00317.
DR TRANSCOMPEL: C00349.
DR UniProtKB: P42226; STA6_HUMAN.
XX
RN [1]; RE0003483.
RX PUBMED: 7760829.
RA Quelle F. W., Shimoda K., Thierfelder W., Fischer C., Kim A., Ruben S. M., Cleveland J. L., Pierce J. H., Keegan A. D., Nelms K., Paul W. E., Ihle J. N.
RT Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosporylated in responses to IL-4 and IL-3 but are not required for mitogenesis
RL Mol. Cell. Biol. 15:3336-3343 (1995).
RN [2]; RE0022476.
RX PUBMED: 11572871.
RA Kraus J., Borner C., Giannini E., Hickfang K., Braun H., Mayer P., Hoehe M. R., Ambrosch A., Konig W., Hollt V.
RT Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site.
RL J. Biol. Chem. 276:43901-43908 (2001).
RN [3]; RE0029630.
RX PUBMED: 11994288.
RA Yamada T., Zhu D., Saxon A., Zhang K.
RT CD45 controls interleukin-4-mediated IgE class switch recombination in human B cells through its function as a Janus kinase phosphatase.
RL J. Biol. Chem. 277:28830-5 (2002).
RN [4]; RE0029945.
RX PUBMED: 12435740.
RA Kovanen P. E., Rosenwald A., Fu J., Hurt E. M., Lam L. T., Giltnane J. M., Wright G., Staudt L. M., Leonard W. J.
RT Analysis of gamma c-family cytokine target genes. Identification of dual-specificity phosphatase 5 (DUSP5) as a regulator of mitogen-activated protein kinase activity in interleukin-2 signaling.
RL J. Biol. Chem. 278:5205-13 (2003).
RN [5]; RE0032828.
RX PUBMED: 11801527.
RA Miscia S., Marchisio M., Grilli A., Di Valerio V., Centurione L., Sabatino G., Garaci F., Zauli G., Bonvini E., Di Baldassarre A.
RT Tumor necrosis factor alpha (TNF-alpha) activates Jak1/Stat3-Stat5B signaling through TNFR-1 in human B cells.
RL Cell Growth Differ. 13:13-8 (2002).
RN [6]; RE0048374.
RX PUBMED: 16810739.
RA Wirnsberger G., Hebenstreit D., Posselt G., Horejs-Hoeck J., Duschl A.
RT IL-4 induces expression of TARC/CCL17 via two STAT6 binding sites.
RL Eur. J. Immunol. 36:1882-1891 (2006).
RN [7]; RE0049465.
RX PUBMED: 16273093.
RA Jones R. B., Gordus A., Krall J. A., MacBeath G.
RT A quantitative protein interaction network for the ErbB receptors using protein microarrays.
RL Nature 439:168-174 (2006).
RN [8]; RE0052482.
RX PUBMED: 15069079.
RA Wang Y., Malabarba M. G., Nagy Z. S., Kirken R. A.
RT Interleukin 4 regulates phosphorylation of serine 756 in the transactivation domain of Stat6. Roles for multiple phosphorylation sites and Stat6 function.
RL J. Biol. Chem. 279:25196-25203 (2004).
RN [9]; RE0052499.
RX PUBMED: 10627454.
RA Pesu M., Takaluoma K., Aittomaki S., Lagerstedt A., Saksela K., Kovanen P. E., Silvennoinen O.
RT Interleukin-4-induced transcriptional activation by stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of stat6.
RL Blood 95:494-502 (2000).
RN [10]; RE0052852.
RX PUBMED: 10713330.
RA Kneitz C., Goller M., Seggewiss R., Yaman A., Serfling E., Tony H. P.
RT STAT6 and the regulation of CD23 expression in B-chronic lymphocytic leukemia.
RL Leuk. Res. 24:331-337 (2000).
RN [11]; RE0054714.
RX PUBMED: 15634336.
RA Hekerman P., Zeidler J., Bamberg-Lemper S., Knobelspies H., Lavens D., Tavernier J., Joost H. G., Becker W.
RT Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines.
RL FEBS J. 272:109-119 (2005).
RN [12]; RE0064742.
RX PUBMED: 18774776.
RA Nishi N., Yamamoto S., Ou W., Muro E., Inada Y., Hamasaki Y.
RT Enhanced CCL26 production by IL-4 through IFN-gamma-induced upregulation of type 1 IL-4 receptor in keratinocytes.
RL Biochem. Biophys. Res. Commun. 376:234-240 (2008).
RN [13]; RE0065249.
RX PUBMED: 16951370.
RA Rahman M. S., Yamasaki A., Yang J., Shan L., Halayko A. J., Gounni A. S.
RT IL-17A induces eotaxin-1/CC chemokine ligand 11 expression in human airway smooth muscle cells: role of MAPK (Erk1/2, JNK, and p38) pathways.
RL J. Immunol. 177:4064-4071 (2006).
RN [14]; RE0068941.
RX PUBMED: 14697238.
RA Yamamoto T., Imoto S., Sekine Y., Sugiyama K., Akimoto T., Muraguchi A., Matsuda T.
RT Involvement of NF-kappaB in TGF-beta-mediated suppression of IL-4 signaling.
RL Biochem. Biophys. Res. Commun. 313:627-634 (2004).
RN [15]; RE0069187.
RX PUBMED: 18945965.
RA Tahvanainen J., Kallonen T., Lahteenmaki H., Heiskanen K. M., Westermarck J., Rao K. V., Lahesmaa R.
RT PRELI is a mitochondrial regulator of human primary T-helper cell apoptosis, STAT6, and Th2-cell differentiation.
RL Blood 113:1268-1277 (2009).
RN [16]; RE0069503.
RX PUBMED: 20974963.
RA Rochman Y., Kashyap M., Robinson G. W., Sakamoto K., Gomez-Rodriguez J., Wagner K. U., Leonard W. J.
RT Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
RL Proc. Natl. Acad. Sci. USA 107:19455-19460 (2010).
RN [17]; RE0070409.
RX PUBMED: 17624801.
RA Liu C., Mills J., Dixon K., Vennarini J., Cunningham M., Del Vecchio A., Das A., Glass W.
RT IL-16 signaling specifically induces STAT6 activation through CD4.
RL Cytokine 38:145-150 (2007).
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