AC T08994
XX
ID T08994
XX
DT 05.06.2006 (created); din.
DT 17.09.2014 (updated); pos.
CO Copyright (C), QIAGEN.
XX
FA HIF-1alpha-isoform1
XX
SY HIF1alpha; hypoxia Induced Factor 1 alpha; hypoxia-inducible factor 1alpha; member of PAS superfamily 1; MOP1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003959 HIF1A; HGNC: HIF1A.
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CL C0010; bHLH; 1.2.5.1.5.1.
XX
SZ 826 AA; 92.7 kDa (cDNA) (calc.), 120 kDa (SDS)
XX
SQ MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
SQ RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
SQ GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
SQ TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
SQ TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
SQ TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
SQ LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
SQ DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
SQ NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
SQ AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
SQ VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
SQ DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
SQ KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
SQ RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
XX
SC translated from EMBL #U22431
XX
FT 16 71 
PS50888; HLH.
FT 18 71 
PF00010; Helix-loop-helix DNA-binding domain.
FT 23 78 
SM00353; finulus.
FT 87 153 
SM00091; pas_2.
FT 93 158 
PS50112; PAS.
FT 230 296 
SM00091; pas_2.
FT 247 298 
PS50112; PAS.
FT 302 345 
SM00086; pac_2.
FT 401 603 
ODD (oxygen-dependent degradation) domain [9].
FT 531 583 
TAD-1 [19].
FT 573 817 PF00478; IMP dehydrogenase / GMP reductase domain.
FT 775 826 TAD-2 [19].
XX
IN T10835 arnt; human, Homo sapiens.
IN T02214 CBP-isoform1; human, Homo sapiens.
IN T34277 mcm7; human, Homo sapiens.
IN T33892 MTA-1; Mammalia.
IN T01427 p300; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T23097 Slim-3; Mammalia.
XX
MX M00976 V$AHRHIF_Q6.
MX M02378 V$HIF1AARNT_01.
MX M07384 V$HIF1A_Q3.
MX M07043 V$HIF1A_Q5.
MX M02012 V$HIF1A_Q6.
MX M00797 V$HIF1_Q3.
MX M00466 V$HIF1_Q5.
XX
BS R18841.
BS R18842.
BS R18844.
BS R18845.
BS R18846.
BS R30398.
XX
DR TRANSPATH: MO000082449.
DR EMBL: U22431;
DR EMBL: U29165;
DR UniProtKB: Q16665-1;
XX
RN [1]; RE0003597.
RX PUBMED: 7539918.
RA Wang G. L., Jiang B.-H., Rue E. A., Semenza G. L.
RT Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
RL Proc. Natl. Acad. Sci. USA 92:5510-5514 (1995).
RN [2]; RE0013068.
RX PUBMED: 8816435.
RA Gradin K., Guire J., Wenger R. H., Kvietikova I., Whitelaw M. L., Toftgard R., Tora L., Gassmann M., Poellinger L.
RT Functional interference between hypoxia and dioxin signal transduction pathways: competition for recruitment of the Arnt transcription factor
RL Mol. Cell. Biol. 16:5221-5231 (1996).
RN [3]; RE0013520.
RX PUBMED: 9000051.
RA Tian H., McKnight S. L., Russel D. W.
RT Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
RL Genes Dev. 11:72-82 (1997).
RN [4]; RE0013592.
RX PUBMED: 9079689.
RA Hogenesch J. B., Chan W. K., Jackiw V. H., Brown R. C., Gu Y.-Z., Pray-Grant M., Perdew G. H., Bradfield C. A.
RT Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
RL J. Biol. Chem. 272:8581-8593 (1997).
RN [5]; RE0021482.
RX PUBMED: 12097158.
RA Tsuchiya T., Kominato Y., Ueda M.
RT Human Hypoxic Signal Transduction through a Signature Motif in Hepatocyte Nuclear Factor 4
RL J. Biochem. 132:37-44 (2002).
RN [6]; RE0022318.
RX PUBMED: 11823643.
RA Lando D., Peet D. J., Whelan D. A., Gorman J. J., Whitelaw M. L.
RT Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.
RL Science 295:858-861 (2002).
RN [7]; RE0022327.
RX PUBMED: 11595184.
RA Epstein A. C., Gleadle J. M., McNeill L. A., Hewitson K. S., O'Rourke J., Mole D. R., Mukherji M., Metzen E., Wilson M. I., Dhanda A., Tian Y.-M., Masson N., Hamilton D. L., Jaakkola P., Barstead R., Hodgkin J., Maxwell P. H., Pugh C. W., Schofield C. J., Ratcliffe P. J.
RT C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.
RL Cell 107:43-54 (2001).
RN [8]; RE0022396.
RX PUBMED: 10207038.
RA Chan W. K., Yao G., Gu Y. Z., Bradfield C. A.
RT Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation.
RL J. Biol. Chem. 274:12115-12123 (1999).
RN [9]; RE0022414.
RX PUBMED: 9653127.
RA Huang L. E., Gu J., Schau M., Bunn H. F.
RT Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.
RL Proc. Natl. Acad. Sci. USA 95:7987-7992 (1998).
RN [10]; RE0022425.
RX PUBMED: 11100117.
RA Kung A. L., Wang S., Klco J. M., Kaelin W. G., Livingston D. M.
RT Suppression of tumor growth through disruption of hypoxia-inducible transcription.
RL Nat. Med. 6:1335-1340 (2000).
RN [11]; RE0022461.
RX PUBMED: 11382768.
RA Fatyol K., Szalay A. A.
RT The p14ARF tumor suppressor protein facilitates nucleolar sequestration of hypoxia-inducible factor-1alpha (HIF-1alpha ) and inhibits HIF-1-mediated transcription.
RL J. Biol. Chem. 276:28421-28429 (2001).
RN [12]; RE0064662.
RX PUBMED: 17875644.
RA Baek J. H., Liu Y. V., McDonald K. R., Wesley J. B., Zhang H., Semenza G. L.
RT Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha.
RL J. Biol. Chem. 282:33358-33366 (2007).
RN [13]; RE0068723.
RX PUBMED: 16511565.
RA Yoo Y. G., Kong G., Lee M. O.
RT Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.
RL EMBO J. 25:1231-1241 (2006).
RN [14]; RE0068774.
RX PUBMED: 15721254.
RA Baek J. H., Mahon P. C., Oh J., Kelly B., Krishnamachary B., Pearson M., Chan D. A., Giaccia A. J., Semenza G. L.
RT OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
RL Mol. Cell 17:503-512 (2005).
RN [15]; RE0068793.
RX PUBMED: 17382325.
RA Cho H., Ahn D. R., Park H., Yang E. G.
RT Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha.
RL FEBS Lett. 581:1542-1548 (2007).
RN [16]; RE0068794.
RX PUBMED: 18838541.
RA Koh M. Y., Darnay B. G., Powis G.
RT Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.
RL Mol. Cell. Biol. 28:7081-7095 (2008).
RN [17]; RE0068903.
RX PUBMED: 19147576.
RA Aprelikova O., Pandolfi S., Tackett S., Ferreira M., Salnikow K., Ward Y., Risinger J. I., Barrett J. C., Niederhuber J.
RT Melanoma antigen-11 inhibits the hypoxia-inducible factor prolyl hydroxylase 2 and activates hypoxic response.
RL Cancer Res. 69:616-624 (2009).
RN [18]; RE0069561.
RX PUBMED: 20699359.
RA Kalousi A., Mylonis I., Politou A. S., Chachami G., Paraskeva E., Simos G.
RT Casein kinase 1 regulates human hypoxia-inducible factor HIF-1.
RL J. Cell Sci. 123:2976-2986 (2010).
RN [19]; RE0047485.
RX PUBMED: 11237857.
RA Kietzmann T., Cornesse Y., Brechtel K., Modaressi S., Jungermann K.
RT Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver.
RL Biochem. J. 354:531-537 (2001).
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