AC T25618
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ID T25618
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DT 12.08.2002 (created); cch.
DT 17.05.2013 (updated); prb.
CO Copyright (C), QIAGEN.
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FA Cdc6
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SY CDC18-like; CDC18L, HsCDC6, HsCDC18; CDC6 cell division cycle 6 homolog; CDC6-related protein; HsCDC18; HsCDC6; p62(cdc6).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G001725 CDC6; HGNC: CDC6.
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FF Cdc6 binds to chromatin important in the initiation of DNA replication [1];
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IN T01610 HIF-1alpha; human, Homo sapiens.
IN T03335 HOXD13; human, Homo sapiens.
IN T16381 HOXD13; Mammalia.
IN T34275 mcm5; human, Homo sapiens.
IN T34277 mcm7; human, Homo sapiens.
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DR TRANSPATH: MO000032415.
DR UniProtKB: Q99741;
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RN [1]; RE0021083.
RX PUBMED: 12151338.
RA Pelizon C., d'Adda di Fagagna F., Farrace L., Laskey R. A.
RT Human replication protein Cdc6 is selectively cleaved by caspase 3 during apoptosis
RL EMBO Rep. 3:780-784 (2002).
RN [2]; RE0049886.
RX PUBMED: 14517333.
RA Yim H., Jin Y. H., Park B. D., Choi H. J., Lee S. K.
RT Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49-truncated Cdc6 and apoptosis.
RL Mol. Biol. Cell 14:4250-4259 (2003).
RN [3]; RE0049893.
RX PUBMED: 16801388.
RA Yim H., Hwang I. S., Choi J. S., Chun K. H., Jin Y. H., Ham Y. M., Lee K. Y., Lee S. K.
RT Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells.
RL J. Cell Biol. 174:77-88 (2006).
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