AC T04597
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ID T04597
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DT 17.07.2001 (created); mas.
DT 09.04.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA SKIP
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SY BX42-homolog; NCoA-62; SKI-interacting protein; SNW1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002746 SNW1; HGNC: SNW1.
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SF nuclear receptor coactivator [3];
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CP (adult:) high levels in pancreas, placenta [3]; also expressed in kidney, skeletal muscle, liver, lung, brain, heart [3] [3].
EX brain,,,adult; high; Northern blot; mRNA (poly-A); [3].
EX heart,,,adult; medium; Northern blot; mRNA (poly-A); [3].
EX kidney (right and left),,,adult; high; Northern blot; mRNA (poly-A); [3].
EX liver,,,adult; high; Northern blot; mRNA (poly-A); [3].
EX lung (right and left),,,adult; medium; Northern blot; mRNA (poly-A); [3].
EX muscles,,,adult; medium; Northern blot; mRNA (poly-A); [3].
EX pancreas,,,adult; very high; Northern blot; mRNA (poly-A); [3].
EX placenta,,,adult; very high; Northern blot; mRNA (poly-A); [3].
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FF augments VDR-mediated transcription in response to 1,25-(OH)-vitamin D3 [3];
FF augments ligand-dependent transcription mediated by other nuclear receptors (ER T00261, GR T00335, RAR-alpha T01327) too [3];
FF interacts with Smad-2 T04095 and Smad-3 T04096 to augment TGF-beta dependent transcription [2] [4] [5] [1];
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IN T02776 DAX1; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T00335 GR; mouse, Mus musculus.
IN T01327 NR1B1; mouse, Mus musculus.
IN T18009 Rad21; human, Homo sapiens.
IN T01616 RBPJK; human, Homo sapiens.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T02738 SHP; human, Homo sapiens.
IN T04095 Smad2-L; human, Homo sapiens.
IN T04096 Smad3-isoform1; human, Homo sapiens.
IN T04689 SMRT; human, Homo sapiens.
IN T00885 VDR; human, Homo sapiens.
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DR TRANSPATH: MO000028431.
DR UniProtKB: Q13573;
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RN [1]; RE0006171.
RX PUBMED: 8774881.
RA Zhang Y., Feng X. H., Wu R. Y., Derynck R.
RT Receptor-associated Mad homologues synergize as effectors of the TGF-beta response
RL Nature 383:168-172 (1996).
RN [2]; RE0015727.
RX PUBMED: 9311995.
RA Nakao A., Imamura T., Souchelnytskyi S., Kawabata M., Ishisaki A., Oeda E., Tamaki K., Hanai J., Heldin C. H., Miyazono K., ten Dijke P.
RT TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
RL EMBO J. 16:5353-5362 (1997).
RN [3]; RE0016437.
RX PUBMED: 9632709.
RA Baudino T. A., Kraichely D. M., Jefcoat SC J. r., Winchester S. K., Partridge N. C., MacDonald P. N.
RT Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription
RL J. Biol. Chem. 273:16434-16441 (1998).
RN [4]; RE0016440.
RX PUBMED: 11278756.
RA Leong G. M., Subramaniam N., Figueroa J., Flanagan J. L., Hayman M. J., Eisman J. A., Kouzmenko A. P.
RT Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription
RL J. Biol. Chem. 276:18243-18248 (2001).
RN [5]; RE0016458.
RX PUBMED: 9006934.
RA Nakao A., Roijer E., Imamura T., Souchelnytskyi S., Stenman G., Heldin C. H., ten Dijke P.
RT Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway
RL J. Biol. Chem. 272:2896-2900 (1997).
RN [6]; RE0051072.
RX PUBMED: 16159877.
RA McCracken S., Longman D., Marcon E., Moens P., Downey M., Nickerson J. A., Jessberger R., Wilde A., Caceres J. F., Emili A., Blencowe B. J.
RT Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.
RL J. Biol. Chem. 280:42227-42236 (2005).
RN [7]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
RN [8]; RE0063261.
RX PUBMED: 16169070.
RA Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F. H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., Timm J., Mintzlaff S., Abraham C., Bock N., Kietzmann S., Goedde A., Toksoz E., Droege A., Krobitsch S., Korn B., Birchmeier W., Lehrach H., Wanker E. E.
RT A human protein-protein interaction network: a resource for annotating the proteome.
RL Cell 122:957-968 (2005).
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