AC T18009
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ID T18009
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DT 15.07.2004 (created); cch.
DT 27.01.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA Rad21
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SY CDLS4; double-strand-break repair protein rad21 homolog; FLJ25655; FLJ40596; hHR21; HR21; HRAD21; KIAA0078; MCD1; nuclear matrix protein 1; NXP-1; NXP1; RAD21; RAD21 homolog (S. pombe); SCC1; SCC1 homolog.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009746 RAD21; HGNC: RAD21.
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FF Rad21 is a component of the mitotic cohesin complex, that links sister chromatids [1];
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IN T04597 SKIP; human, Homo sapiens.
IN T28756 SMC-3; human, Homo sapiens.
IN T28176 SMC1; human, Homo sapiens.
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MX M04697 V$RAD21_01.
MX M04739 V$RAD21_02.
MX M04752 V$RAD21_03.
MX M04785 V$RAD21_04.
MX M04850 V$RAD21_10.
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DR TRANSPATH: MO000042938.
DR UniProtKB: O60216;
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RN [1]; RE0024510.
RX PUBMED: 11875078.
RA Chen F., Kamradt M., Mulcahy M., Byun Y., Xu H., McKay M. J., Cryns V. L.
RT Caspase proteolysis of the cohesin component RAD21 promotes apoptosis.
RL J. Biol. Chem. 277:16775-16781 (2002).
RN [2]; RE0027287.
RX PUBMED: 11076961.
RA Sumara I., Vorlaufer E., Gieffers C., Peters B. H., Peters J. M.
RT Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase.
RL J. Cell Biol. 151:749-762 (2000).
RN [3]; RE0029444.
RX PUBMED: 11590136.
RA Gregson H. C., Schmiesing J. A., Kim J. S., Kobayashi T., Zhou S., Yokomori K.
RT A potential role for human cohesin in mitotic spindle aster assembly.
RL J. Biol. Chem. 276:47575-82 (2001).
RN [4]; RE0049499.
RX PUBMED: 17113138.
RA Kueng S., Hegemann B., Peters B. H., Lipp J. J., Schleiffer A., Mechtler K., Peters J. M.
RT Wapl controls the dynamic association of cohesin with chromatin.
RL Cell 127:955-967 (2006).
RN [5]; RE0049555.
RX PUBMED: 16510521.
RA Toyoda Y., Yanagida M.
RT Coordinated requirements of human topo II and cohesin for metaphase centromere alignment under Mad2-dependent spindle checkpoint surveillance.
RL Mol. Biol. Cell 17:2287-2302 (2006).
RN [6]; RE0050410.
RX PUBMED: 17349791.
RA Schmitz J., Watrin E., Lenart P., Mechtler K., Peters J. M.
RT Sororin is required for stable binding of cohesin to chromatin and for sister chromatid cohesion in interphase.
RL Curr. Biol. 17:630-636 (2007).
RN [7]; RE0050559.
RX PUBMED: 16322207.
RA Martin S. A., Ouchi T.
RT BRCA1 phosphorylation regulates caspase-3 activation in UV-induced apoptosis.
RL Cancer Res. 65:10657-10662 (2005).
RN [8]; RE0050985.
RX PUBMED: 15737063.
RA Hauf S., Roitinger E., Koch B., Dittrich C. M., Mechtler K., Peters J. M.
RT Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.
RL PLoS Biol. 3:e69 (2005).
RN [9]; RE0051072.
RX PUBMED: 16159877.
RA McCracken S., Longman D., Marcon E., Moens P., Downey M., Nickerson J. A., Jessberger R., Wilde A., Caceres J. F., Emili A., Blencowe B. J.
RT Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.
RL J. Biol. Chem. 280:42227-42236 (2005).
RN [10]; RE0051089.
RX PUBMED: 11073952.
RA Hoque M. T., Ishikawa F.
RT Human chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeres.
RL J. Biol. Chem. 276:5059-5067 (2001).
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