AC T01616
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ID T01616
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DT 26.01.1996 (created); ewi.
DT 30.09.2015 (updated); jtr.
CO Copyright (C), QIAGEN.
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FA RBPJK
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SY C-promoter binding factor 1; CBF1; CSL; Epstein-Barr virus C-promoter binding factor 1; human C Promoter Binding Factor 1; IGKJRB; IGKJRB1; Jk; RBP-J; RBP-J kappa; RBP-Jkappa; RBPJK; RBPSUH; recombination signal-binding protein of Jkappa.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006642 RBPJ; HGNC: RBPJ.
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HO Su(H) (Drosophila).
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CL C0020; Rel; 6.1.4.1.1.
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SF at least 3 isoforms exist;
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FF transcriptional repressor [4];
FF mediates DNA-binding of viral EBNA-2 activator [3];
FF repressing domain masked by interaction with EBNA-2 [4];
FF Notch signaling converts RBPJK from a transcriptional repressor to a transcriptional activator [6];
FF RBPJK functions as a positive regulator of human IL-6 gene transcription [5];
FF RBPJK binding motifs overlap with NF-kappaB elements, indicating a novel role for RBPJK in silencing NF-kappaB-inducible transcription;
FF human NF-kappaB promoter can be activated by truncated Notch1 (NICD) [7];
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IN T01618 EBNA-2; EBV, Epstein-Barr virus.
IN T05110 Ku70; human, Homo sapiens.
IN T05111 Ku80; human, Homo sapiens.
IN T15693 Mam-1; human, Homo sapiens.
IN T16105 NICD1; human, Homo sapiens.
IN T25615 NICD1; human, Homo sapiens.
IN T04597 SKIP; human, Homo sapiens.
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MX M01112 V$RBPJK_01.
MX M01111 V$RBPJK_Q4.
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BS R25601.
BS R28177.
BS R12725.
BS R28016.
BS R12720.
BS R25598.
BS R61523.
BS R12722.
BS R12708.
BS R25016.
BS R63991.
BS R61513.
BS R28232.
BS R12718.
BS R12721.
BS R28218.
BS R37463.
BS R27998.
BS R27985.
BS R27986.
BS R12723.
BS R12717.
BS R61520.
BS R29815.
BS R29817.
BS R29434.
BS R12724.
BS R39803.
BS R69829.
BS R12706.
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DR TRANSPATH: MO000030964.
DR TRANSCOMPEL: C00324.
DR TRANSCOMPEL: C00552.
DR UniProtKB: Q06330;
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RN [1]; RE0003605.
RX PUBMED: 7958912.
RA Brou C., Logeat F., Lecourtois M., Vandekerckhove J., Kourilsky P., Schweisguth F., Israel A.
RT Inhibition of the DNA-binding activity of Drosophila Suppressor of Hairless and of its human homolog, KBF2/RBP-Jkappa, by direct protein-protein interaction with Drosophila Hairless
RL Genes Dev. 8:2491-2503 (1994).
RN [2]; RE0003607.
RX PUBMED: 8406481.
RA Amakawa R., Jing W., Ozawa K., Matsunami N., Hamaguchi Y., Matsuda F., Kawaichi M., Honjo T.
RT Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue
RL Genomics 17:306-315 (1993).
RN [3]; RE0003610.
RX PUBMED: 8016657.
RA Henkel T., Ling P. D., Hayward S. D., Peterson M. G.
RT Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein Jkappa
RL Science 265:92-95 (1994).
RN [4]; RE0003611.
RX PUBMED: 7725102.
RA Hsieh J. J.-D., Hayward S. D.
RT Masking of the CBF1/RBPJkappa transcriptional repression domain by Epstein-Barr Virus EBNA2
RL Science 268:560-563 (1995).
RN [5]; RE0017527.
RX PUBMED: 9516466.
RA Miyazawa K., Mori A., Yamamoto K., Okudaira H.
RT Transcriptional roles of CCAAT/enhancer binding protein-beta, nuclear factor-kappaB, and C-promoter binding factor 1 in interleukin (IL)-1beta-induced IL-6 synthesis by human rheumatoid fibroblast-like synoviocytes.
RL J. Biol. Chem. 273:7620-7627 (1998).
RN [6]; RE0017852.
RX PUBMED: 9604939.
RA Struhl G., Adachi A.
RT Nuclear access and action of notch in vivo.
RL Cell 93:649-660 (1998).
RN [7]; RE0017862.
RX PUBMED: 9528780.
RA Oswald F., Liptay S., Adler G., Schmid R. M.
RT NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa.
RL Mol. Cell. Biol. 18:2077-2088 (1998).
RN [8]; RE0055718.
RX PUBMED: 16530044.
RA Nam Y., Sliz P., Song L., Aster J. C., Blacklow S. C.
RT Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.
RL Cell 124:973-983 (2006).
RN [9]; RE0063191.
RX PUBMED: 14570916.
RA Lim J. W., Kim H., Kim K. H.
RT The Ku antigen-recombination signal-binding protein Jkappa complex binds to the nuclear factor-kappaB p50 promoter and acts as a positive regulator of p50 expression in human gastric cancer cells.
RL J. Biol. Chem. 279:231-237 (2004).
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