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TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN


AC T01616 XX ID T01616 XX DT 26.01.1996 (created); ewi. DT 30.09.2015 (updated); jtr. CO Copyright (C), QIAGEN. XX FA RBPJK XX SY C-promoter binding factor 1; CBF1; CSL; Epstein-Barr virus C-promoter binding factor 1; human C Promoter Binding Factor 1; IGKJRB; IGKJRB1; Jk; RBP-J; RBP-J kappa; RBP-Jkappa; RBPJK; RBPSUH; recombination signal-binding protein of Jkappa. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G006642 RBPJ; HGNC: RBPJ. XX HO Su(H) (Drosophila). XX CL C0020; Rel; 6.1.4.1.1. XX SF at least 3 isoforms exist; XX FF transcriptional repressor [4]; FF mediates DNA-binding of viral EBNA-2 activator [3]; FF repressing domain masked by interaction with EBNA-2 [4]; FF Notch signaling converts RBPJK from a transcriptional repressor to a transcriptional activator [6]; FF RBPJK functions as a positive regulator of human IL-6 gene transcription [5]; FF RBPJK binding motifs overlap with NF-kappaB elements, indicating a novel role for RBPJK in silencing NF-kappaB-inducible transcription; FF human NF-kappaB promoter can be activated by truncated Notch1 (NICD) [7]; XX IN T01618 EBNA-2; EBV, Epstein-Barr virus. IN T05110 Ku70; human, Homo sapiens. IN T05111 Ku80; human, Homo sapiens. IN T15693 Mam-1; human, Homo sapiens. IN T16105 NICD1; human, Homo sapiens. IN T25615 NICD1; human, Homo sapiens. IN T04597 SKIP; human, Homo sapiens. XX MX M01112 V$RBPJK_01. MX M01111 V$RBPJK_Q4. XX BS R25601. BS R28177. BS R12725. BS R28016. BS R12720. BS R25598. BS R61523. BS R12722. BS R12708. BS R25016. BS R63991. BS R61513. BS R28232. BS R12718. BS R12721. BS R28218. BS R37463. BS R27998. BS R27985. BS R27986. BS R12723. BS R12717. BS R61520. BS R29815. BS R29817. BS R29434. BS R12724. BS R39803. BS R69829. BS R12706. XX DR TRANSPATH: MO000030964. DR TRANSCOMPEL: C00324. DR TRANSCOMPEL: C00552. DR UniProtKB: Q06330; XX RN [1]; RE0003605. RX PUBMED: 7958912. RA Brou C., Logeat F., Lecourtois M., Vandekerckhove J., Kourilsky P., Schweisguth F., Israel A. RT Inhibition of the DNA-binding activity of Drosophila Suppressor of Hairless and of its human homolog, KBF2/RBP-Jkappa, by direct protein-protein interaction with Drosophila Hairless RL Genes Dev. 8:2491-2503 (1994). RN [2]; RE0003607. RX PUBMED: 8406481. RA Amakawa R., Jing W., Ozawa K., Matsunami N., Hamaguchi Y., Matsuda F., Kawaichi M., Honjo T. RT Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue RL Genomics 17:306-315 (1993). RN [3]; RE0003610. RX PUBMED: 8016657. RA Henkel T., Ling P. D., Hayward S. D., Peterson M. G. RT Mediation of Epstein-Barr virus EBNA2 transactivation by recombination signal-binding protein Jkappa RL Science 265:92-95 (1994). RN [4]; RE0003611. RX PUBMED: 7725102. RA Hsieh J. J.-D., Hayward S. D. RT Masking of the CBF1/RBPJkappa transcriptional repression domain by Epstein-Barr Virus EBNA2 RL Science 268:560-563 (1995). RN [5]; RE0017527. RX PUBMED: 9516466. RA Miyazawa K., Mori A., Yamamoto K., Okudaira H. RT Transcriptional roles of CCAAT/enhancer binding protein-beta, nuclear factor-kappaB, and C-promoter binding factor 1 in interleukin (IL)-1beta-induced IL-6 synthesis by human rheumatoid fibroblast-like synoviocytes. RL J. Biol. Chem. 273:7620-7627 (1998). RN [6]; RE0017852. RX PUBMED: 9604939. RA Struhl G., Adachi A. RT Nuclear access and action of notch in vivo. RL Cell 93:649-660 (1998). RN [7]; RE0017862. RX PUBMED: 9528780. RA Oswald F., Liptay S., Adler G., Schmid R. M. RT NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa. RL Mol. Cell. Biol. 18:2077-2088 (1998). RN [8]; RE0055718. RX PUBMED: 16530044. RA Nam Y., Sliz P., Song L., Aster J. C., Blacklow S. C. RT Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. RL Cell 124:973-983 (2006). RN [9]; RE0063191. RX PUBMED: 14570916. RA Lim J. W., Kim H., Kim K. H. RT The Ku antigen-recombination signal-binding protein Jkappa complex binds to the nuclear factor-kappaB p50 promoter and acts as a positive regulator of p50 expression in human gastric cancer cells. RL J. Biol. Chem. 279:231-237 (2004). XX //