TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01676 XX ID T01676 XX DT 20.02.1996 (created); ewi. DT 27.01.2015 (updated); ros. CO Copyright (C), QIAGEN. XX FA EKLF XX SY erythroid Krueppel-like factor; KLF1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G001081 Klf1. XX CL C0001; CH; XX SF possible upstream translation initiation would lead to a 376 AA peptide of 39.9 kDa [6]; SF the whole amino-terminal domain (9-269) is proline-rich; SF EKLF binds to CACCC elements [6]; SF mutated CACCC sites in the beta-globin gene that cause beta-thalassemia do not bind EKLF [3] [5]; XX CP erythroid tissues, bone marrow, spleen [6], testis [1] [1] [6]. CN brain, heart, kidney, liver, lung, lymph node, muscle, ovary, small intestine, stomach, thymus [6]. XX FF activator [6]; FF may facilitate the hemoglobin gamma to beta switch [3]; FF the EKLF gene is regulated by GATA-1 T00305 [4]; FF EKLF and GATA-1 T00305 interact and synergize in activation of gene expression [7]; FF embryonal expression starts by E11 and peaks at E15/E17 [1]; XX IN T15118 CBP; Mammalia. IN T00305 GATA-1; mouse, Mus musculus. IN T02956 HIRA; mouse, Mus musculus. IN T23091 p300; Mammalia. IN T25617 sin3a; mouse, Mus musculus. XX MX M01874 V$EKLF_Q5. MX M07281 V$EKLF_Q5_01. MX M07106 V$KLF1_01. MX M07461 V$KLF_Q3. XX BS R56639. BS R15671. BS R61279. XX DR TRANSPATH: MO000025861. DR UniProtKB: P46099; XX RN [1]; RE0003813. RX PUBMED: 7565748. RA Anderson K. P., Kern C. B., Crable S. C., Lingrel J. B. RT Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krueppel-like factor: Identification of a new multigene family RL Mol. Cell. Biol. 15:5957-5965 (1995). RN [2]; RE0003824. RX PUBMED: 7823951. RA Bieker J. J., Southwood C. M. RT The erythroid Krueppel-like factor transactivation domain is a critical component for cell-specific inducibility of a beta-globin promoter RL Mol. Cell. Biol. 15:852-860 (1995). RN [3]; RE0003825. RX PUBMED: 7753195. RA Perkins A. C., Sharpe A. H., Orkin S. H. RT Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF RL Nature 375:318-322 (1995). RN [4]; RE0003826. RX PUBMED: 8195185. RA Crossley M., Tsang A. P., Bieker J. J., Orkin S. H. RT Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1 RL J. Biol. Chem. 269:15440-15444 (1994). RN [5]; RE0003827. RX PUBMED: 8288615. RA Feng W. C., Southwood C. M., Bieker J. J. RT Analyses of beta-thalassemia mutant DNA interactions with erythroid Krueppel-like factor (EKLF), an erythroid cell-specific transcription factor RL J. Biol. Chem. 269:1493-1500 (1994). RN [6]; RE0003828. RX PUBMED: 7682653. RA Miller I. J., Bieker J. J. RT A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Krueppel family of nuclear proteins RL Mol. Cell. Biol. 13:2776-2786 (1993). RN [7]; RE0010577. RX PUBMED: 7739528. RA Merika M., Orkin S. H. RT Functional synergy and physical interactions of the erythroid transcription factor GATA-1 with the Krueppel family proteins Sp1 and EKLF RL Mol. Cell. Biol. 15:2437-2447 (1995). RN [8]; RE0031242. RX PUBMED: 11544260. RA Ingley E., Chappell D., Poon S. Y., Sarna M. K., Beaumont J. G., Williams J. H., Stillitano J. P., Tsai S., Leedman P. J., Tilbrook P. A., Klinken S. P. RT Thyroid hormone receptor-interacting protein 1 modulates cytokine and nuclear hormone signaling in erythroid cells. RL J. Biol. Chem. 276:43428-34 (2001). RN [9]; RE0035585. RX PUBMED: 9707565. RA Zhang W., Bieker J. J. RT Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases. RL Proc. Natl. Acad. Sci. USA 95:9855-9860 (1998). RN [10]; RE0046907. RX PUBMED: 9334239. RA Surinya K. H., Cox T. C., May B. K. RT Transcriptional regulation of the human erythroid 5-aminolevulinate synthase gene. Identification of promoter elements and role of regulatory proteins RL J. Biol. Chem. 272:26585-94 (1997). RN [11]; RE0047821. RX PUBMED: 11287616. RA Chen X., Bieker J. J. RT Unanticipated repression function linked to erythroid Kruppel-like factor. RL Mol. Cell. Biol. 21:3118-3125 (2001). RN [12]; RE0048042. RX PUBMED: 15542849. RA Chen X., Bieker J. J. RT Stage-specific repression by the EKLF transcriptional activator. RL Mol. Cell. Biol. 24:10416-10424 (2004). XX //