AC T01799
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ID T01799
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DT 08.05.1996 (created); ewi.
DT 11.12.2009 (updated); sla.
CO Copyright (C), QIAGEN.
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FA Tal-1
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SY pp42-TAL1; SCL; stem-cell leukemia protein; T-cell acute lymphocytic leukemia-1 protein; Tal-1; Tal-1alpha; TCL5.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G001189 Tal1.
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CL C0010; bHLH.
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SZ 329 AA; 34.3 kDa (cDNA) (calc.).
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SQ MTERPPSEAARSDPQLEGQDAAEARMAPPHLVLLNGVAKETSRAAPAEPPVIELGARSGA
SQ GGGPASGGGAARDLKGRDAVAAEARLRVPTTELCRPPGPAPAPAPASAPAELPGDGRMVQ
SQ LSPPALAAPAGPGRALLYSLSQPLASLGSGFFGEPDAFPMFTNNNRVKRRPSPYEMEISD
SQ GPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLA
SQ KLLNDQEEEGTQRAKPGKDPVVGAGGGGAGGGIPPEDLLQDVLSPNSSCGSSLDGAASPD
SQ SYTEEPTPKHTSRSLHPALLPAADGAGPR
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SC Swiss-Prot#P22091
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FT 188 240 
PF00010; Helix-loop-helix DNA-binding domain.
FT 188 240 
PS50888; HLH.
FT 193 245 
SM00353; finulus.
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SF eight exons give rise to several splice variants [3];
SF Tal-1 complexes with LIM-proteins Lmo2/RBTN2 in erythroid cells and Lmo1/RBTN1 in T-ALL cells [1] [4];
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CP mast cells [2].
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FF enhanced expression in erythroleukemia cells upon induction of differentiation [2];
FF regulator of the vascular development, together with GATA-2 and Ets factors [5];
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IN T10133 CLIM2-isoform1; mouse, Mus musculus.
IN T17415 E12; Mammalia.
IN T00207 E47; human, Homo sapiens.
IN T10212 E47; Mammalia.
IN T21852 HDAC1; Mammalia.
IN T02249 LMO1; human, Homo sapiens.
IN T25677 p300; mouse, Mus musculus.
IN T02250 RBTN2-isoform1; human, Homo sapiens.
IN T02251 RBTN2; mouse, Mus musculus.
IN T10141 RBTN2; mouse, Mus musculus.
IN T19340 RFP; mouse, Mus musculus.
IN T25617 sin3a; mouse, Mus musculus.
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MX M01034 V$EBOX_Q6_01.
MX M00066 V$TAL1ALPHAE47_01.
MX M00065 V$TAL1BETAE47_01.
MX M00070 V$TAL1BETAITF2_01.
MX M01591 V$TAL1_01.
MX M00993 V$TAL1_Q6.
MX M03804 V$TAL1_Q6_01.
MX M07469 V$TALLIKE_Q6.
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BS R04764.
BS R04157.
BS R14484.
BS R00850.
BS R04158.
BS R14467.
BS R14468.
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DR TRANSPATH: MO000025936.
DR EMBL: M59764;
DR EMBL: U01530;
DR UniProtKB: P22091;
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RN [1]; RE0003640.
RX PUBMED: 7957052.
RA Wadman I., Li J., Bash R. O., Forster A., Osada H., Rabbitts T. H., Baer R.
RT Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia
RL EMBO J. 13:4831-4839 (1994).
RN [2]; RE0003643.
RX PUBMED: 2000219.
RA Visvader J., Begley C. G., Adams J. M.
RT Differential expression of the LYL, SCL and E2A helix-loop-helix genes within the hemopoietic system
RL Oncogene 6:187-194 (1991).
RN [3]; RE0004033.
RX PUBMED: 8125323.
RA Begley C. G., Robb L., Rockman S., Visvader J., Bockamp E. O., Chan Y. S., Green A. R.
RT Structure of the gene encoding the murine SCL protein
RL Gene 138:93-99 (1994).
RN [4]; RE0006083.
RX PUBMED: 8078932.
RA Valge-Archer V. E., Osada H., Warren A. J., Forster A., Li J., Baer R., Rabbitts T. H.
RT The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells
RL Proc. Natl. Acad. Sci. USA 91:8617-8621 (1994).
RN [5]; RE0023734.
RX PUBMED: 11049987.
RA Kappel A., Schlaeger T. M., Flamme I., Orkin S. H., Risau W., Breier G.
RT Role of SCL/Tal-1, GATA, and ets transcription factor binding sites for the regulation of flk-1 expression during murine vascular development.
RL Blood 96:3078-3085 (2000).
RN [6]; RE0035566.
RX PUBMED: 10688671.
RA Huang S., Brandt S. J.
RT mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor.
RL Mol. Cell. Biol. 20:2248-2259 (2000).
RN [7]; RE0048230.
RX PUBMED: 16007160.
RA Bloor A. J., Kotsopoulou E., Hayward P., Champion B. R., Green A. R.
RT RFP represses transcriptional activation by bHLH transcription factors.
RL Oncogene 24:6729-6736 (2005).
RN [8]; RE0049146.
RX PUBMED: 16287841.
RA Schuh A. H., Tipping A. J., Clark A. J., Hamlett I., Guyot B., Iborra F. J., Rodriguez P., Strouboulis J., Enver T., Vyas P., Porcher C.
RT ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis.
RL Mol. Cell. Biol. 25:10235-10250 (2005).
RN [9]; RE0049178.
RX PUBMED: 15314159.
RA Schlaeger T. M., Schuh A., Flitter S., Fisher A., Mikkola H., Orkin S. H., Vyas P., Porcher C.
RT Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.
RL Mol. Cell. Biol. 24:7491-7502 (2004).
RN [10]; RE0049197.
RX PUBMED: 11904294.
RA Tang T., Arbiser J. L., Brandt S. J.
RT Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells.
RL J. Biol. Chem. 277:18365-18372 (2002).
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