AC T02250
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ID T02250
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DT 29.10.1997 (created); ewi.
DT 24.09.2008 (updated); pwa.
CO Copyright (C), QIAGEN.
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FA RBTN2-isoform1
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SY LIM-only protein 2; LMO2a; RBTN2; Rhombotin-2; TTG-2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004692 LMO2; HGNC: LMO2.
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CL C0028; LIM.
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SZ 158 AA; 18.4 kDa (cDNA) (calc.).
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SQ MSSAIERKSLDPSEEPVDEVLQIPPSLLTCGGCQQNIGDRYFLKAIDQYWHEDCLSCDLC
SQ GCRLGEVGRRLYYKLGRKLCRRDYLRLFGQDGLCASCDKRIRAYEMTMRVKDKVYHLECF
SQ KCAACQKHFCVGDRYLLINSDIVCEQDIYEWTKINGMI
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SC Swiss-Prot#P25791-1
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FT 28 90 
PS50023; LIM_DOMAIN_2.
FT 29 83 
SM00132; lim_4.
FT 30 89 
PF00412; LIM domain.
FT 92 154 
PS50023; LIM_DOMAIN_2.
FT 93 147 
SM00132; lim_4.
FT 94 153 
PF00412; LIM domain.
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SF specifically interacts with Tal-1 in erythroid cells [1] [3];
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FF associated with t(11;
FF 14)(p13;
FF q11) translocations in T cell leukemias [4];
FF essential for erythroid differentiation [4];
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IN T02252 CLIM2; mouse, Mus musculus.
IN T01632 Lyl-1; human, Homo sapiens.
IN T00722 pRb; human, Homo sapiens.
IN T01799 Tal-1; mouse, Mus musculus.
IN T00790 Tal1-PP42; human, Homo sapiens.
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DR TRANSPATH: MO000026257.
DR EMBL: X61118;
DR UniProtKB: P25791-1;
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RN [1]; RE0003640.
RX PUBMED: 7957052.
RA Wadman I., Li J., Bash R. O., Forster A., Osada H., Rabbitts T. H., Baer R.
RT Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia
RL EMBO J. 13:4831-4839 (1994).
RN [2]; RE0006078.
RX PUBMED: 1923511.
RA Royer-Pokora B., Loos L., Ludwig W. D.
RT TTG-2 a new gene encoding a cyseine rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with t(11;14) (p13;q11)
RL Oncogene 6:1887-1893 (1991).
RN [3]; RE0006083.
RX PUBMED: 8078932.
RA Valge-Archer V. E., Osada H., Warren A. J., Forster A., Li J., Baer R., Rabbitts T. H.
RT The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells
RL Proc. Natl. Acad. Sci. USA 91:8617-8621 (1994).
RN [4]; RE0006590.
RX PUBMED: 7568177.
RA Osada H., Grutz G., Axelson H., Forster A., Rabbitts T. H.
RT Association of erythroid transcription factors: Complexes involving the LIM protein RBTN2 and the zinc finger protein GATA1
RL Proc. Natl. Acad. Sci. USA 92:9585-9589 (1995).
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//