TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01632 XX ID T01632 XX DT 31.01.1996 (created); ewi. DT 18.07.2013 (updated); yre. CO Copyright (C), QIAGEN. XX FA Lyl-1 XX SY bHLHa18; LYL1; lymphoblastic leukemia derived sequence 1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003961 LYL1; HGNC: LYL1. XX CL C0010; bHLH; XX SF sequence of 267 AA is N-terminally truncated [2]; SF a 280 AA version matches murine sequence; SF interacts with the LIM-only proteins Lmo1/RBTN1 and Lmo2/RBTN2 [1]; XX FF located near the t(7; FF 19) chromosomal breakpoint causing cell transformation [2] [3]; XX IN T15605 E2A; human, Homo sapiens. IN T02249 LMO1; human, Homo sapiens. IN T02250 RBTN2-isoform1; human, Homo sapiens. XX MX M07469 V$TALLIKE_Q6. XX BS R39579. XX DR TRANSPATH: MO000025819. DR UniProtKB: P12980; XX RN [1]; RE0003640. RX PUBMED: 7957052. RA Wadman I., Li J., Bash R. O., Forster A., Osada H., Rabbitts T. H., Baer R. RT Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia RL EMBO J. 13:4831-4839 (1994). RN [2]; RE0003641. RX PUBMED: 2752424. RA Mellentin J. D., Smith S. D., Cleary M. L. RT lyl-1, a novel gene involved by chromosomal translocation in T-cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif RL Cell 58:77-83 (1989). RN [3]; RE0003644. RX PUBMED: 3162254. RA Cleary M. L., Mellentin J. D., Spies J., Smith S. D. RT Chromosomal translocation involving the beta T cell receptor gene in acute leukemia RL J. Exp. Med. 167:682-687 (1988). RN [4]; RE0012731. RX PUBMED: 8628307. RA Miyamoto A., Cui X., Naumovski L., Cleary M. L. RT Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells RL Mol. Cell. Biol. 16:2394-2401 (1996). XX //