AC T01632
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ID T01632
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DT 31.01.1996 (created); ewi.
DT 18.07.2013 (updated); yre.
CO Copyright (C), QIAGEN.
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FA Lyl-1
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SY bHLHa18; LYL1; lymphoblastic leukemia derived sequence 1.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003961 LYL1; HGNC: LYL1.
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CL C0010; bHLH; 1.2.3.1.3.
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SF sequence of 267 AA is N-terminally truncated [2];
SF a 280 AA version matches murine sequence;
SF interacts with the LIM-only proteins Lmo1/RBTN1 and Lmo2/RBTN2 [1];
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FF located near the t(7;
FF 19) chromosomal breakpoint causing cell transformation [2] [3];
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IN T15605 E2A; human, Homo sapiens.
IN T02249 LMO1; human, Homo sapiens.
IN T02250 RBTN2-isoform1; human, Homo sapiens.
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MX M07469 V$TALLIKE_Q6.
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BS R39579.
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DR TRANSPATH: MO000025819.
DR UniProtKB: P12980;
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RN [1]; RE0003640.
RX PUBMED: 7957052.
RA Wadman I., Li J., Bash R. O., Forster A., Osada H., Rabbitts T. H., Baer R.
RT Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia
RL EMBO J. 13:4831-4839 (1994).
RN [2]; RE0003641.
RX PUBMED: 2752424.
RA Mellentin J. D., Smith S. D., Cleary M. L.
RT lyl-1, a novel gene involved by chromosomal translocation in T-cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif
RL Cell 58:77-83 (1989).
RN [3]; RE0003644.
RX PUBMED: 3162254.
RA Cleary M. L., Mellentin J. D., Spies J., Smith S. D.
RT Chromosomal translocation involving the beta T cell receptor gene in acute leukemia
RL J. Exp. Med. 167:682-687 (1988).
RN [4]; RE0012731.
RX PUBMED: 8628307.
RA Miyamoto A., Cui X., Naumovski L., Cleary M. L.
RT Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells
RL Mol. Cell. Biol. 16:2394-2401 (1996).
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