AC T02251
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ID T02251
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DT 29.10.1997 (created); ewi.
DT 24.09.2008 (updated); pwa.
CO Copyright (C), QIAGEN.
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FA RBTN2
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SY LIM-only protein 2; RBTN2; Rhombotin-2; TTG-2.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G006364 Lmo2.
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CL C0028; LIM.
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SF specifically interacts with Tal-1 in erythroid cells [1] [3];
SF interacts with GATA-1in erythroid cells, LIM domain may be responsible for this interaction [4] [5];
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CP E 12 embryo, adult spleen, adult lung, low level in adult thymus [6].
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FF important for erythropoiesis [5];
FF may form a bridge in high order complex that comprises GATA-1, Tal-1 and E47 [5];
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IN T02252 CLIM2; mouse, Mus musculus.
IN T00305 GATA-1; mouse, Mus musculus.
IN T00308 GATA-2; human, Homo sapiens.
IN T01799 Tal-1; mouse, Mus musculus.
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DR TRANSPATH: MO000026258.
DR UniProtKB: P25801;
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RN [1]; RE0003640.
RX PUBMED: 7957052.
RA Wadman I., Li J., Bash R. O., Forster A., Osada H., Rabbitts T. H., Baer R.
RT Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia
RL EMBO J. 13:4831-4839 (1994).
RN [2]; RE0006079.
RX PUBMED: 2034676.
RA Boehm T., Foroni L., Kaneko Y., Perutz M. F., Rabbitts T. H.
RT The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13
RL Proc. Natl. Acad. Sci. USA 88:4367-4371 (1991).
RN [3]; RE0006083.
RX PUBMED: 8078932.
RA Valge-Archer V. E., Osada H., Warren A. J., Forster A., Li J., Baer R., Rabbitts T. H.
RT The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells
RL Proc. Natl. Acad. Sci. USA 91:8617-8621 (1994).
RN [4]; RE0006584.
RX PUBMED: 9478126.
RA MacKay J. P., Crossley M.
RT Zinc fingers are sticking together
RL Trends Biochem. Sci. 23:1-4 (1998).
RN [5]; RE0006590.
RX PUBMED: 7568177.
RA Osada H., Grutz G., Axelson H., Forster A., Rabbitts T. H.
RT Association of erythroid transcription factors: Complexes involving the LIM protein RBTN2 and the zinc finger protein GATA1
RL Proc. Natl. Acad. Sci. USA 92:9585-9589 (1995).
RN [6]; RE0024611.
RX PUBMED: 9736723.
RA Kenny D. A., Jurata L. W., Saga Y., Gill G. N.
RT Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis.
RL Dev. Biol. 95:11257-11262 (1998).
RN [7]; RE0049146.
RX PUBMED: 16287841.
RA Schuh A. H., Tipping A. J., Clark A. J., Hamlett I., Guyot B., Iborra F. J., Rodriguez P., Strouboulis J., Enver T., Vyas P., Porcher C.
RT ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis.
RL Mol. Cell. Biol. 25:10235-10250 (2005).
RN [8]; RE0049178.
RX PUBMED: 15314159.
RA Schlaeger T. M., Schuh A., Flitter S., Fisher A., Mikkola H., Orkin S. H., Vyas P., Porcher C.
RT Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.
RL Mol. Cell. Biol. 24:7491-7502 (2004).
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