TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02251 XX ID T02251 XX DT 29.10.1997 (created); ewi. DT 24.09.2008 (updated); pwa. CO Copyright (C), QIAGEN. XX FA RBTN2 XX SY LIM-only protein 2; RBTN2; Rhombotin-2; TTG-2. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G006364 Lmo2. XX CL C0028; LIM. XX SF specifically interacts with Tal-1 in erythroid cells [1] [3]; SF interacts with GATA-1in erythroid cells, LIM domain may be responsible for this interaction [4] [5]; XX CP E 12 embryo, adult spleen, adult lung, low level in adult thymus [6]. XX FF important for erythropoiesis [5]; FF may form a bridge in high order complex that comprises GATA-1, Tal-1 and E47 [5]; XX IN T02252 CLIM2; mouse, Mus musculus. IN T00305 GATA-1; mouse, Mus musculus. IN T00308 GATA-2; human, Homo sapiens. IN T01799 Tal-1; mouse, Mus musculus. XX DR TRANSPATH: MO000026258. DR UniProtKB: P25801; XX RN [1]; RE0003640. RX PUBMED: 7957052. RA Wadman I., Li J., Bash R. O., Forster A., Osada H., Rabbitts T. H., Baer R. RT Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia RL EMBO J. 13:4831-4839 (1994). RN [2]; RE0006079. RX PUBMED: 2034676. RA Boehm T., Foroni L., Kaneko Y., Perutz M. F., Rabbitts T. H. RT The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13 RL Proc. Natl. Acad. Sci. USA 88:4367-4371 (1991). RN [3]; RE0006083. RX PUBMED: 8078932. RA Valge-Archer V. E., Osada H., Warren A. J., Forster A., Li J., Baer R., Rabbitts T. H. RT The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells RL Proc. Natl. Acad. Sci. USA 91:8617-8621 (1994). RN [4]; RE0006584. RX PUBMED: 9478126. RA MacKay J. P., Crossley M. RT Zinc fingers are sticking together RL Trends Biochem. Sci. 23:1-4 (1998). RN [5]; RE0006590. RX PUBMED: 7568177. RA Osada H., Grutz G., Axelson H., Forster A., Rabbitts T. H. RT Association of erythroid transcription factors: Complexes involving the LIM protein RBTN2 and the zinc finger protein GATA1 RL Proc. Natl. Acad. Sci. USA 92:9585-9589 (1995). RN [6]; RE0024611. RX PUBMED: 9736723. RA Kenny D. A., Jurata L. W., Saga Y., Gill G. N. RT Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis. RL Dev. Biol. 95:11257-11262 (1998). RN [7]; RE0049146. RX PUBMED: 16287841. RA Schuh A. H., Tipping A. J., Clark A. J., Hamlett I., Guyot B., Iborra F. J., Rodriguez P., Strouboulis J., Enver T., Vyas P., Porcher C. RT ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis. RL Mol. Cell. Biol. 25:10235-10250 (2005). RN [8]; RE0049178. RX PUBMED: 15314159. RA Schlaeger T. M., Schuh A., Flitter S., Fisher A., Mikkola H., Orkin S. H., Vyas P., Porcher C. RT Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. RL Mol. Cell. Biol. 24:7491-7502 (2004). XX //