AC T05934
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ID T05934
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DT 03.05.2004 (created); oke.
DT 25.05.2015 (updated); pro.
CO Copyright (C), QIAGEN.
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FA REST
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SY neuron-restrictive silencer factor; NRSF; RE-1 silencing transcription factor; X2-box repressor; XBR.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G009400 Rest.
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CL C0001; CH; 2.3.4.0.27.
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SF member of the Krueppel family of zinc-finger TFs;
SF several alternative transcripts and/or splice variants are known;
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CP widely expressed; particular splice variants are expressed in brain neurons [2]; NS20Y cells [6].
CN PC12 cells [6].
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FF repressor;
FF represses neuron-specific genes in non-neuronal tissues;
FF represses BDNF promoters I and II in the neurons of brain [1];
FF interacts with huntingtin in neurons which results in the activation (de-repression) of target genes [2];
FF subject for post-translational modifications;
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IN T25617 sin3a; mouse, Mus musculus.
IN T05840 Sp3; mouse, Mus musculus.
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MX M00325 V$NRSE_B.
MX M00256 V$NRSF_01.
MX M01028 V$NRSF_Q4.
MX M01256 V$REST_01.
MX M05532 V$REST_14.
MX M03883 V$REST_Q5.
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BS R21262.
BS R42046.
BS R21265.
BS R15639.
BS R21279.
BS R21250.
BS R21261.
BS R21318.
BS R21320.
BS R21252.
BS R21253.
BS R61112.
BS R42258.
BS R36005.
BS R36009.
BS R20094.
BS R42259.
BS R42261.
BS R15680.
BS R14827.
BS R67613.
BS R22646.
BS R15655.
BS R15654.
BS R15608.
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DR TRANSPATH: MO000041618.
DR TRANSCOMPEL: C00505.
DR UniProtKB: Q8VIG1; Q8VIG1.
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RN [1]; RE0024160.
RX PUBMED: 9873054.
RA Timmusk T., Palm K., Lendahl U., Metsis M.
RT Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element.
RL J. Biol. Chem. 274:1078-1084 (1999).
RN [2]; RE0024164.
RX PUBMED: 12881722.
RA Zuccato C., Tartari M., Crotti A., Goffredo D., Valenza M., Conti L., Cataudella T., Leavitt B. R., Hayden M. R., Timmusk T., Rigamonti D., Cattaneo E.
RT Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.
RL Nat. Genet. 35:76-83 (2003).
RN [3]; RE0048202.
RX PUBMED: 10734093.
RA Grimes J. A., Nielsen S. J., Battaglioli E., Miska E. A., Speh J. C., Berry D. L., Atouf F., Holdener B. C., Mandel G., Kouzarides T.
RT The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex.
RL J. Biol. Chem. 275:9461-9467 (2000).
RN [4]; RE0048203.
RX PUBMED: 10688661.
RA Roopra A., Sharling L., Wood I. C., Briggs T., Bachfischer U., Paquette A. J., Buckley N. J.
RT Transcriptional repression by neuron-restrictive silencer factor is mediated via the Sin3-histone deacetylase complex.
RL Mol. Cell. Biol. 20:2147-2157 (2000).
RN [5]; RE0048204.
RX PUBMED: 14645515.
RA Shimojo M., Hersh L. B.
RT REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor.
RL Mol. Cell. Biol. 23:9025-9031 (2003).
RN [6]; RE0049991.
RX PUBMED: 17130167.
RA Kim C. S., Choi H. S., Hwang C. K., Song K. Y., Lee B. K., Law P. Y., Wei L. N., Loh H. H.
RT Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene.
RL Nucleic Acids Res. 34:6392-6403 (2006).
RN [7]; RE0049998.
RX PUBMED: 15755907.
RA Qiang M., Rani C. S., Ticku M. K.
RT Neuron-restrictive silencer factor regulates the N-methyl-D-aspartate receptor 2B subunit gene in basal and ethanol-induced gene expression in fetal cortical neurons.
RL Mol. Pharmacol. 67:2115-2125 (2005).
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