AC T06598
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ID T06598
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DT 23.05.2005 (created); oke.
DT 08.06.2016 (updated); sla.
CO Copyright (C), QIAGEN.
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FA AML-1
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SY Acute Myeloid Leukemia 1; AML1; CBFA2; PEBP2aB; Pebpa2b; Runx1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005053 Runx1.
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CL C0029; runt; 6.4.1.0.2.
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SF generic entry for several alternative products encoded by the mouse Runx1 gene, see PEBP2alphaB1 T02235, PEBP2alphaB2 T02241;
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CP EM-3 and BMM cell lines [7].
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FF Binding of Runx1 to the promoter region of INK4b is disrupted by chimeric protein CBFbeta-SMMHC [6];
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IN T15601 AR; Mammalia.
IN T22468 BCL11A-isoform1; human, Homo sapiens.
IN T10346 c-Fos; Mammalia.
IN T00133 c-Jun; human, Homo sapiens.
IN T01318 CBP; mouse, Mus musculus.
IN T01408 Fli-1; mouse, Mus musculus.
IN T10058 Fli-1; mouse, Mus musculus.
IN T04178 FOXO3a; mouse, Mus musculus.
IN T00305 GATA-1; mouse, Mus musculus.
IN T10446 GR; Mammalia.
IN T10542 p300; mouse, Mus musculus.
IN T25677 p300; mouse, Mus musculus.
IN T01064 PEBP2beta; mouse, Mus musculus.
IN T06379 PML; mouse, Mus musculus.
IN T25617 sin3a; mouse, Mus musculus.
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MX M00271 V$AML1_01.
MX M01658 V$AML1_Q4.
MX M07242 V$AML1_Q4_01.
MX M08865 V$AML1_Q4_02.
MX M02084 V$AML1_Q5.
MX M00751 V$AML1_Q6.
MX M08866 V$AML_Q4.
MX M00769 V$AML_Q6.
MX M00984 V$PEBP_Q6.
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BS R23230.
BS R23234.
BS R73946.
BS R23683.
BS R23684.
BS R19732.
BS R28959.
BS R28960.
BS R20208.
BS R73656.
BS R73674.
BS R73677.
BS R73678.
BS R73679.
BS R23677.
BS R23682.
BS R61959.
BS R61965.
BS R69988.
BS R69991.
BS R68672.
BS R68673.
BS R30626.
BS R04644.
BS R63247.
BS R63248.
BS R63249.
BS R73754.
BS R73755.
BS R73956.
BS R35035.
BS R64904.
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DR TRANSPATH: MO000054457.
DR TRANSCOMPEL: C00173.
DR TRANSCOMPEL: C00185.
DR UniProtKB: Q03347;
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RN [1]; RE0023220.
RX PUBMED: 11274169.
RA Hess J., Porte D., Munz C., Angel P.
RT AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element.
RL J. Biol. Chem. 276:20029-20038 (2001).
RN [2]; RE0035828.
RX PUBMED: 10521447.
RA Ning Y. M., Robins D. M.
RT AML3/CBFalpha1 is required for androgen-specific activation of the enhancer of the mouse sex-limited protein (Slp) gene.
RL J. Biol. Chem. 274:30624-30630 (1999).
RN [3]; RE0039427.
RX PUBMED: 9606182.
RA Kitabayashi I., Yokoyama A., Shimizu K., Ohki M.
RT Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation
RL EMBO J. 17:2994-3004 (1998).
RN [4]; RE0048225.
RX PUBMED: 15123671.
RA Liu H., Holm M., Xie X. Q., Wolf-Watz M., Grundstrom T.
RT AML1/Runx1 recruits calcineurin to regulate granulocyte macrophage colony-stimulating factor by Ets1 activation.
RL J. Biol. Chem. 279:29398-29408 (2004).
RN [5]; RE0049455.
RX PUBMED: 16917507.
RA Aikawa Y., Nguyen L. A., Isono K., Takakura N., Tagata Y., Schmitz M. L., Koseki H., Kitabayashi I.
RT Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.
RL EMBO J. 25:3955-3965 (2006).
RN [6]; RE0052106.
RX PUBMED: 17283131.
RA Markus J., Garin M. T., Bies J., Galili N., Raza A., Thirman M. J., Le Beau M. M., Rowley J. D., Liu P. P., Wolff L.
RT Methylation-independent silencing of the tumor suppressor INK4b (p15) by CBFbeta-SMMHC in acute myelogenous leukemia with inv(16).
RL Cancer Res. 67:992-1000 (2007).
RN [7]; RE0052364.
RX PUBMED: 16007221.
RA Himes S. R., Cronau S., Mulford C., Hume D. A.
RT The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophages.
RL Oncogene 24:5278-5286 (2005).
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