TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T06598 XX ID T06598 XX DT 23.05.2005 (created); oke. DT 08.06.2016 (updated); sla. CO Copyright (C), QIAGEN. XX FA AML-1 XX SY Acute Myeloid Leukemia 1; AML1; CBFA2; PEBP2aB; Pebpa2b; Runx1. XX OS mouse, Mus musculus OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae XX GE G005053 Runx1. XX CL C0029; runt; XX SF generic entry for several alternative products encoded by the mouse Runx1 gene, see PEBP2alphaB1 T02235, PEBP2alphaB2 T02241; XX CP EM-3 and BMM cell lines [7]. XX FF Binding of Runx1 to the promoter region of INK4b is disrupted by chimeric protein CBFbeta-SMMHC [6]; XX IN T15601 AR; Mammalia. IN T22468 BCL11A-isoform1; human, Homo sapiens. IN T10346 c-Fos; Mammalia. IN T00133 c-Jun; human, Homo sapiens. IN T01318 CBP; mouse, Mus musculus. IN T01408 Fli-1; mouse, Mus musculus. IN T10058 Fli-1; mouse, Mus musculus. IN T04178 FOXO3a; mouse, Mus musculus. IN T00305 GATA-1; mouse, Mus musculus. IN T10446 GR; Mammalia. IN T10542 p300; mouse, Mus musculus. IN T25677 p300; mouse, Mus musculus. IN T01064 PEBP2beta; mouse, Mus musculus. IN T06379 PML; mouse, Mus musculus. IN T25617 sin3a; mouse, Mus musculus. XX MX M00271 V$AML1_01. MX M01658 V$AML1_Q4. MX M07242 V$AML1_Q4_01. MX M08865 V$AML1_Q4_02. MX M02084 V$AML1_Q5. MX M00751 V$AML1_Q6. MX M08866 V$AML_Q4. MX M00769 V$AML_Q6. MX M00984 V$PEBP_Q6. XX BS R23230. BS R23234. BS R73946. BS R23683. BS R23684. BS R19732. BS R28959. BS R28960. BS R20208. BS R73656. BS R73674. BS R73677. BS R73678. BS R73679. BS R23677. BS R23682. BS R61959. BS R61965. BS R69988. BS R69991. BS R68672. BS R68673. BS R30626. BS R04644. BS R63247. BS R63248. BS R63249. BS R73754. BS R73755. BS R73956. BS R35035. BS R64904. XX DR TRANSPATH: MO000054457. DR TRANSCOMPEL: C00173. DR TRANSCOMPEL: C00185. DR UniProtKB: Q03347; XX RN [1]; RE0023220. RX PUBMED: 11274169. RA Hess J., Porte D., Munz C., Angel P. RT AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element. RL J. Biol. Chem. 276:20029-20038 (2001). RN [2]; RE0035828. RX PUBMED: 10521447. RA Ning Y. M., Robins D. M. RT AML3/CBFalpha1 is required for androgen-specific activation of the enhancer of the mouse sex-limited protein (Slp) gene. RL J. Biol. Chem. 274:30624-30630 (1999). RN [3]; RE0039427. RX PUBMED: 9606182. RA Kitabayashi I., Yokoyama A., Shimizu K., Ohki M. RT Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation RL EMBO J. 17:2994-3004 (1998). RN [4]; RE0048225. RX PUBMED: 15123671. RA Liu H., Holm M., Xie X. Q., Wolf-Watz M., Grundstrom T. RT AML1/Runx1 recruits calcineurin to regulate granulocyte macrophage colony-stimulating factor by Ets1 activation. RL J. Biol. Chem. 279:29398-29408 (2004). RN [5]; RE0049455. RX PUBMED: 16917507. RA Aikawa Y., Nguyen L. A., Isono K., Takakura N., Tagata Y., Schmitz M. L., Koseki H., Kitabayashi I. RT Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. RL EMBO J. 25:3955-3965 (2006). RN [6]; RE0052106. RX PUBMED: 17283131. RA Markus J., Garin M. T., Bies J., Galili N., Raza A., Thirman M. J., Le Beau M. M., Rowley J. D., Liu P. P., Wolff L. RT Methylation-independent silencing of the tumor suppressor INK4b (p15) by CBFbeta-SMMHC in acute myelogenous leukemia with inv(16). RL Cancer Res. 67:992-1000 (2007). RN [7]; RE0052364. RX PUBMED: 16007221. RA Himes S. R., Cronau S., Mulford C., Hume D. A. RT The Runx1 transcription factor controls CSF-1-dependent and -independent growth and survival of macrophages. RL Oncogene 24:5278-5286 (2005). XX //