AC T04178
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ID T04178
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DT 15.01.2001 (created); rio.
DT 13.07.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA FOXO3a
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SY C76856; FKHR2; FKHRL1; forkhead box O3; forkhead box O3A; Foxo3; FOXO3A.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002643 Foxo3.
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CL C0023; fork head; 3.3.1.15.2.
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SF 94% amino acid identity to human FOXO3aa T02938, 100% identity within the fork head domain [2];
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CP (E15.5:) liver, (adult:) ubiquitous, higher level in heart, brain, spleen, kidney, moderate in white adipose tissue, testis, little in skeletal muscle [2] [3]; increased expression during starvation (0h, 6H, 12h) with a peak after 24h, which returned to basal level by 24h of refeeding [16].
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FF govern cell growth in the heart [6];
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IN T06598 AML-1; mouse, Mus musculus.
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MX M01137 V$FOXO3A_Q1.
MX M07287 V$FOXO3A_Q3.
MX M00477 V$FOXO3_01.
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BS R09923.
BS R09924.
BS R26380.
BS R63988.
BS R61699.
BS R68754.
BS R68755.
BS R26379.
BS R66470.
BS R68750.
BS R68751.
BS R68753.
BS R70167.
BS R31044.
BS R68723.
BS R68728.
BS R68731.
BS R68749.
BS R59028.
BS R26632.
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DR TRANSPATH: MO000028071.
DR UniProtKB: Q9WVH4;
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RN [1]; RE0015570.
RA Biggs W. H., Cavenee W. K., Arden K. C.
RT Identification and Characterization of Murine Members of the FKHR Subclass of Winged-Helix Transcription Factors
RL direct submission (EMBL) : ().
RN [2]; RE0016820.
RX PUBMED: 11353388.
RA Biggs W. H. 3rd, Cavenee W. K., Arden K. C.
RT Identification and characterization of members of the FKHR (FOX O) subclass of winged-helix transcription factors in the mouse
RL Mamm. Genome 12:416-425 (2001).
RN [3]; RE0016824.
RX PUBMED: 10880363.
RA Furuyama T., Nakazawa T., Nakano I., Mori N.
RT Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues
RL Biochem. J. 349:629-634 (2000).
RN [4]; RE0032615.
RX PUBMED: 15084260.
RA Hu M. C., Lee D. F., Xia W., Golfman L. S., Ou-Yang F., Yang J. Y., Zou Y., Bao S., Hanada N., Saso H., Kobayashi R., Hung M. C.
RT IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
RL Cell 117:225-37 (2004).
RN [5]; RE0032966.
RX PUBMED: 11953455.
RA Zheng W. H., Kar S., Quirion R.
RT FKHRL1 and its homologs are new targets of nerve growth factor Trk receptor signaling.
RL J. Neurochem 80:1049-61 (2002).
RN [6]; RE0048486.
RX PUBMED: 16952979.
RA Ni Y. G., Berenji K., Wang N., Oh M., Sachan N., Dey A., Cheng J., Lu G., Morris D. J., Castrillon D. H., Gerard R. D., Rothermel B. A., Hill J. A.
RT Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling.
RL Circulation 114:1159-1168 (2006).
RN [7]; RE0051245.
RX PUBMED: 17965779.
RA Li H. H., Willis M. S., Lockyer P., Miller N., McDonough H., Glass D. J., Patterson C.
RT Atrogin-1 inhibits Akt-dependent cardiac hypertrophy in mice via ubiquitin-dependent coactivation of Forkhead proteins.
RL J. Clin. Invest. 117:3211-3223 (2007).
RN [8]; RE0051909.
RX PUBMED: 18204439.
RA Yang J. Y., Zong C. S., Xia W., Yamaguchi H., Ding Q., Xie X., Lang J. Y., Lai C. C., Chang C. J., Huang W. C., Huang H., Kuo H. P., Lee D. F., Li L. Y., Lien H. C., Cheng X., Chang K. J., Hsiao C. D., Tsai F. J., Tsai C. H., Sahin A. A., Muller W. J., Mills G. B., Yu D., Hortobagyi G. N., Hung M. C.
RT ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation.
RL Nat. Cell Biol. 10:138-148 (2008).
RN [9]; RE0064535.
RX PUBMED: 19088189.
RA Mandal M., Crusio K. M., Meng F., Liu S., Kinsella M., Clark M. R., Takeuchi O., Aifantis I.
RT Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid.
RL Proc. Natl. Acad. Sci. USA 105:20840-20845 (2008).
RN [10]; RE0067981.
RX PUBMED: 18678662.
RA Snoeks L., Weber C. R., Turner J. R., Bhattacharyya M., Wasland K., Savkovic S. D.
RT Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells.
RL Infect. Immun. 76:4677-4685 (2008).
RN [11]; RE0068651.
RX PUBMED: 19696026.
RA Sengupta A., Molkentin J. D., Yutzey K. E.
RT FoxO transcription factors promote autophagy in cardiomyocytes.
RL J. Biol. Chem. 284:28319-28331 (2009).
RN [12]; RE0070024.
RX PUBMED: 19841191.
RA Escribano C., Delgado-Martin C., Rodriguez-Fernandez J. L.
RT CCR7-dependent stimulation of survival in dendritic cells involves inhibition of GSK3beta.
RL J. Immunol. 183:6282-6295 (2009).
RN [13]; RE0070735.
RX PUBMED: 20110348.
RA Singh A., Ye M., Bucur O., Zhu S., Tanya Santos M., Rabinovitz I., Wei W., Gao D., Hahn W. C., Khosravi-Far R.
RT Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT.
RL Mol. Biol. Cell 21:1140-1152 (2010).
RN [14]; RE0071546.
RX PUBMED: 21965295.
RA Diebold I., Petry A., Burger M., Hess J., Gorlach A.
RT NOX4 mediates activation of FoxO3a and matrix metalloproteinase-2 expression by urotensin-II.
RL Mol. Biol. Cell 22:4424-4434 (2011).
RN [15]; RE0024940.
RX PUBMED: 15286700.
RA Dominguez-Caceres M. A., Garcia-Martinez J. M., Calcabrini A., Gonzalez L., Porque P. G., Leon J., Martin-Perez J.
RT Prolactin induces c-Myc expression and cell survival through activation of Src/Akt pathway in lymphoid cells.
RL Oncogene 23:7378-7390 (2004).
RN [16]; RE0035532.
RX PUBMED: 12820900.
RA Furuyama T., Kitayama K., Yamashita H., Mori N.
RT Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation.
RL Biochem. J. 375:365-371 (2003).
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