AC T01064
AS T00683, T00687.
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ID T01064
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DT 24.02.1994 (created); ewi.
DT 09.01.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA PEBP2beta
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SY CBFbeta; core-binding factor, beta subunit; MyNF1beta; PEBP2beta.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G014226 Cbfb.
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HO FLV-1; Bro, Bgb.
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CL C0029; runt.
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SF composed of one alpha- (30 kDa) and one beta-subunit (20 kDa);
SF several gene products are known, for example PEBP2beta2 T01065;
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FF activator;
FF may form a complex with factors PU.1, C/EBP and c-Myb on the neutrophil elastase gene promoter which stimulates binding of the basal transcription machinery [10];
FF dephosphorylated form = PEBP3;
FF enhances DNA affinity of the alpha subunit;
FF expressed at relatively uniform levels in all tissues [7];
FF beta subunit protein is cytoplasmic [9];
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IN T06598 AML-1; mouse, Mus musculus.
IN T14315 AML1; Mammalia.
IN T02266 AML3-isoform2; mouse, Mus musculus.
IN T02235 PEBP2alphaB1; mouse, Mus musculus.
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MX M00769 V$AML_Q6.
MX M03841 V$PEBP2B_Q6.
MX M00984 V$PEBP_Q6.
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BS R02927.
BS R15126.
BS R15127.
BS R18139.
BS R01221.
BS R01222.
BS R01226.
BS R01228.
BS R01231.
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DR TRANSPATH: MO000025373.
DR EMBL: D14569;
DR EMBL: D14570;
DR EMBL: D14571;
DR EMBL: D14572;
DR UniProtKB: Q08024;
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RN [1]; RE0000394.
RX PUBMED: 3038517.
RA Piette J., Yaniv M.
RT Two different factors bind to the alpha-domain of the polyoma virus enhancer, one of which also interacts with the SV40 and c-fos enhancers
RL EMBO J. 6:1331-1337 (1987).
RN [2]; RE0001226.
RX PUBMED: 3211130.
RA Bornstein P., McKay J., Liska D. J., Apone S., Devarayalu S.
RT Interaction between the Promoter and First Intron are Involved in Transcriptional Control of alpha1(I) Collagen Gene Expression
RL Mol. Cell. Biol. 8:4851-4857 (1988).
RN [3]; RE0001819.
RX PUBMED: 3037385.
RA Kryszke M.-H., Piette J., Yaniv M.
RT Induction of a factor that binds to the polyoma virus A enhancer on differentiation of embryonal carcinoma cells
RL Nature 328:254-256 (1987).
RN [4]; RE0002018.
RX PUBMED: 3027657.
RA Piette J., Yaniv M.
RT Molecular analysis of the interaction between an enhancer binding factor and its DNA target
RL Nucleic Acids Res. 14:9595-9611 (1986).
RN [5]; RE0002339.
RX PUBMED: 2842750.
RA Martin M. E., Piette J., Yaniv M., Tang W.-J., Folk W. R.
RT Activator of the polyomavirus enhancer by a murine activator protein 1 (AP1) homolog and two contiguous proteins
RL Proc. Natl. Acad. Sci. USA 85:5839-5843 (1988).
RN [6]; RE0002540.
RX PUBMED: 8341710.
RA Ogawa E., Maruyama M., Kagoshima H., Inuzuka M., Lu J., Satake M., Shigesada K., Ito Y.
RT PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene
RL Proc. Natl. Acad. Sci. USA 90:6859-6863 (1993).
RN [7]; RE0006071.
RX PUBMED: 7862157.
RA Satake M., Nomura S., Yamaguchi-Iwai Y., Takahama Y., Hashimoto Y., Niki M., Kitamura Y., Ito Y.
RT Expression of the Runt domain-encoding PEBP2alpha genes in T cells during thymic development
RL Mol. Cell. Biol. 15:1662-1670 (1995).
RN [8]; RE0006084.
RX PUBMED: 7760805.
RA Hernandez-Munain C., Krangel M. S.
RT c-Myb and core-binding factor / PEBP2 display functional synergy but bind independently to adjacent sites in the T-cell receptor delta enhancer
RL Mol. Cell. Biol. 15:3090-3099 (1995).
RN [9]; RE0006088.
RX PUBMED: 7862156.
RA Lu J., Maruyama M., Satake M., Bae S., Ogawa E., Kagoshima H., Shigesada K., Ito Y.
RT Subcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBF
RL Mol. Cell. Biol. 15:1651-1661 (1995).
RN [10]; RE0006500.
RX PUBMED: 8035830.
RA Nuchprayoon I., Meyers S., Scott L. M., Suzow J., Hiebert S., Friedmann A. D.
RT PEBP2/CBF, the murine homolog of the human myeoloid AML1 and PEBP2beta/CBFbeta proto-oncoproteins, regulates the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells
RL Mol. Cell. Biol. 14:5558-5568 (1994).
RN [11]; RE0048819.
RX PUBMED: 16785428.
RA Bose R., Molina H., Patterson A. S., Bitok J. K., Periaswamy B., Bader J. S., Pandey A., Cole P. A.
RT Phosphoproteomic analysis of Her2/neu signaling and inhibition.
RL Proc. Natl. Acad. Sci. USA 103:9773-9778 (2006).
RN [12]; RE0049455.
RX PUBMED: 16917507.
RA Aikawa Y., Nguyen L. A., Isono K., Takakura N., Tagata Y., Schmitz M. L., Koseki H., Kitabayashi I.
RT Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation.
RL EMBO J. 25:3955-3965 (2006).
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