AC T08914
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ID T08914
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DT 12.05.2006 (created); kar.
DT 23.12.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA Smad1
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SY SMAD-1.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002383 Smad1.
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CL C0041; SMAD.
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SZ 465 AA; 52.1 kDa (cDNA) (calc.).
XX
SQ MNVTSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSCPGQ
SQ PSNCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWSDLQSHHELKPLECCEFPFGSKQKEV
SQ CINPYHYKRVESPVLPPVLVPKHSEYNPQHSLLAQFRNLGQNEPHMPLNATFPDSFQQPN
SQ SHPFPHSPNSSYPNSPGGSSSTYPHSPTSSDPGSPFQMPADTPPPAYLPPEDPMAQDGSQ
SQ PMDTNMMAPPLPAEISRGDVQAVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFT
SQ DPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNC
SQ NYHHGFHPTTVCKIPSGCSLKIFNNQEFAQLLAQSVNHGFETVYELTKMCTIRMSFVKGW
SQ GAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
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SC translated from EMBL #AF295768
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FT 12 136 
PS51075; MH1.
FT 25 134 
SM00523; dwAneu5.
FT 27 131 
PF03165; MH1 domain.
FT 31 430 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 265 443 
PF03166; MH2 domain.
FT 269 441 
SM00524; DWB.
FT 271 465 
PS51076; MH2.
XX
IN T09289 HOXA13; mouse, Mus musculus.
IN T09291 HOXD13; mouse, Mus musculus.
IN T11119 SIP1; mouse, Mus musculus.
IN T05067 Smad4; mouse, Mus musculus.
IN T13998 Smad4; Mammalia.
IN T22793 znf8; mouse, Mus musculus.
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MX M01590 V$SMAD1_01.
MX M03845 V$SMAD1_Q6.
MX M08897 V$SMAD_Q4.
MX M00792 V$SMAD_Q6.
MX M00974 V$SMAD_Q6_01.
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BS R16509.
BS R16510.
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DR TRANSPATH: MO000081398.
DR EMBL: AF295768; AF295768.
DR UniProtKB: P70340; SMA1_MOUSE.
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RN [1]; RE0015662.
RX PUBMED: 11111041.
RA Huang S., Flanders K. C., Roberts A. B.
RT Characterization of the mouse smad1 gene and its expression pattern in adult mouse tissues
RL Gene 258:43-53 (2000).
RN [2]; RE0017601.
RX PUBMED: 10400677.
RA Verschueren K., Remacle J. E., Collart C., Kraft H., Baker B. S., Tylzanowski P., Nelles L., Wuytens G., Su M. T., Bodmer R., Smith J. C., Huylebroeck D.
RT SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes.
RL J. Biol. Chem. 274:20489-20498 (1999).
RN [3]; RE0020652.
RX PUBMED: 11509558.
RA Xiao Z., Watson N., Rodriguez C., Lodish H. F.
RT Nucleocytoplasmic shuttling of smad1 conferred by its nuclear localization and nuclear export signals
RL J. Biol. Chem. 276:39404-39410 (2001).
RN [4]; RE0020663.
RX PUBMED: 10224135.
RA Ishisaki A., Yamato K., Hashimoto S., Nakao A., Tamaki K., Nonaka K., ten Dijke P., Sugino H., Nishihara T.
RT Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells
RL J. Biol. Chem. 274:13637-13642 (1999).
RN [5]; RE0044240.
RX PUBMED: 12370310.
RA Jiao K., Zhou Y., Hogan B. L.
RT Identification of mZnf8, a Mouse Kruppel-Like Transcriptional Repressor, as a Novel Nuclear Interaction Partner of Smad1
RL Mol. Cell. Biol. 22:7633-44 (2002).
RN [6]; RE0048182.
RX PUBMED: 16087734.
RA Williams T. M., Williams M. E., Heaton J. H., Gelehrter T. D., Innis J. W.
RT Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability.
RL Nucleic Acids Res. 33:4475-4484 (2005).
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