AC T04643
XX
ID T04643
XX
DT 27.07.2001 (created); dkl.
DT 15.11.2007 (updated); bch.
CO Copyright (C), QIAGEN.
XX
FA c-Ski
XX
SY SKI; SKV; v-ski sarcoma viral oncogene homolog (avian).
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G006726 SKI; HGNC: SKI.
XX
SZ 728 AA; 80.0 kDa (cDNA) (calc.).
XX
SQ MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAV
SQ PAPVPAATEPPPVLHLPAIQPPPPVLPGPFFMPSDRSTERCETVLEGETISCFVVGGEKR
SQ LCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKT
SQ DAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSP
SQ SAACIQCLDCRLMYPPHKFVVHSHKALENRTCHWGFDSANWRAYILLSQDYTGKEEQARL
SQ GRCLDDVKEKFDYGNKYKRRVPRVSSEPPASIRPKTDDTSSQSPAPSEKDKPSSWLRTLA
SQ GSSNKSLGCVHPRQRLSAFRPWSPAVSASEKELSPHLPALIRDSFYSYKSFETAVAPNVA
SQ LAPPAQQKVVSSPPCAAAVSRAPEPLATCTQPRKRKLTVDTPGAPETLAPVAAPEEDKDS
SQ EAEVEVESREEFTSSLSSLSSPSFTSSSSAKDLGSPGARALPSAVPDAAAPADAPSGLEA
SQ ELEHLRQALEGGLDTKEAKEKFLHEVVKMRVKQEEKLSAALQAKRSLHQELEFLRVAKKE
SQ KLREATEAKRNLRKEIERLRAENEKKMKEANESRLRLKRELEQARQARVCDKGCEAGRLR
SQ AKYSAQIEDLQVKLQHAEADREQLRADLLREREAREHLEKVVKELQEQLWPRARPEAAGS
SQ EGAAELEP
XX
SC translated from EMBL #X15218
XX
FT 1 309 
Smad interaction domain [1].
FT 80 192 
PF02437; SKI/SNO/DAC family.
FT 197 261 
interaction domain with Gli3 [3].
FT 246 715 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 338 490 
interaction domain with Smad-2/Smad-3 [1].
XX
FF interacts with Smad-2/Smad-3 in a TGF-beta dependent manner and Smad-4 is also incorporated in this complex [1];
FF is has two distinct Smad interaction domains [1];
FF represses transactivation by TGF-beta [1];
FF it is incorporated in the DNA binding complex of Smads [1];
FF it competes with p300 in binding to Smad-3 [1];
FF it recruits HDAC to Smads [1];
FF it inhibits Smad-associated HAT activity [1];
XX
IN T14622 sin3a; human, Homo sapiens.
IN T10378 Smad3; human, Homo sapiens.
IN T13998 Smad4; Mammalia.
XX
DR TRANSPATH: MO000028476.
DR EMBL: X15218;
DR UniProtKB: P12755;
XX
RN [1]; RE0016412.
RX PUBMED: 10575014.
RA Akiyoshi S., Inoue H., Hanai J., Kusanagi K., Nemoto N., Miyazono K., Kawabata M.
RT c-Ski acts as a transcriptional co-repressor in transforming growth factor-beta signaling through interaction with smads.
RL J. Biol. Chem. 274:35269-35277 (1999).
RN [2]; RE0047884.
RX PUBMED: 14525983.
RA Wu K., Yang Y., Wang C., Davoli M. A., D'Amico M., Li A., Cveklova K., Kozmik Z., Lisanti M. P., Russell R. G., Cvekl A., Pestell R. G.
RT DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.
RL J. Biol. Chem. 278:51673-51684 (2003).
RN [3]; RE0025535.
RX PUBMED: 8706131.
RA Bai C., Sen P., Hofmann K., Ma L., Goebl M., Harper J. W., Elledge S. J.
RT SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
RL Cell 86:263-74 (1996).
XX
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