AC T08951
XX
ID T08951
XX
DT 17.05.2006 (created); jay.
DT 16.12.2015 (updated); smt.
CO Copyright (C), QIAGEN.
XX
FA STAT1
XX
SY 2010005J02Rik; signal transducer and activator of transcription 1; STAT1.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G006765 Stat1.
XX
CL C0039; STAT; 6.2.1.0.1.
XX
CP mammary tissues [9]; B10R [11]; RAW264.7 [14]; RAW264.7, PAM212 [17].
XX
FF STAT1 is activated by IFNgamma [6];
FF Receptors like, CR3 (Complement Receptor 3), Fcgamma R (Receptors for the Fc portion of immunoglobulins gamma) and mannose R (Mannose-fucose Receptor) facilitate the translocation of STAT1 and thereby play a potential role in STAT1 activation [11];
FF Proteasome degrades STAT1, while infected with Leishmania donovani [11];
XX
IN T01806 p53; mouse, Mus musculus.
IN T13998 Smad4; Mammalia.
XX
MX M00224 V$STAT1_01.
MX M00492 V$STAT1_02.
MX M00496 V$STAT1_03.
MX M01260 V$STAT1_05.
MX M07064 V$STAT1_Q4.
MX M01823 V$STAT1_Q6.
MX M00223 V$STAT_01.
MX M00777 V$STAT_Q6.
XX
BS R23951.
BS R24465.
BS R25121.
BS R24063.
BS R35038.
BS R25433.
BS R04223.
BS R26378.
BS R26723.
BS R25854.
BS R26904.
BS R32181.
BS R30006.
BS R30007.
BS R30008.
BS R29678.
BS R26486.
BS R28686.
BS R67972.
BS R67973.
BS R26520.
BS R26522.
BS R59492.
BS R59493.
BS R59494.
BS R59495.
BS R59496.
BS R22333.
BS R26293.
BS R70455.
BS R70457.
BS R70456.
BS R08127.
BS R25136.
BS R32897.
BS R61445.
BS R61439.
BS R57185.
BS R26847.
BS R19616.
BS R67552.
BS R71049.
BS R26840.
BS R33572.
BS R22476.
BS R25945.
BS R57435.
BS R57436.
BS R64014.
BS R34748.
BS R14447.
BS R19622.
BS R66269.
BS R66270.
XX
DR TRANSPATH: MO000081638.
DR TRANSCOMPEL: C00589.
DR UniProtKB: P42225;
XX
RN [1]; RE0010751.
RX PUBMED: 7538664.
RA Ruff-Jamison S., Chen K., Cohen S.
RT Epidermal growth factor induces the tyrosine phosphorylation and nuclear translocation of Stat 5 in mouse liver
RL Proc. Natl. Acad. Sci. USA 92:4215-4218 (1995).
RN [2]; RE0021232.
RX PUBMED: 10228162.
RA Takaoka A., Tanaka N., Mitani Y., Miyazaki T., Fujii H., Sato M., Kovarik P., Decker T., Schlessinger J., Taniguchi T.
RT Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling
RL EMBO J. 18:2480-2488 (1999).
RN [3]; RE0031906.
RX PUBMED: 15012602.
RA Auernhammer C. J., Dorn F., Vlotides G., Hengge S., Kopp F. B., Spoettl G., Cengic N., Engelhardt D., Weber M. M.
RT The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells.
RL J. Endocrinol. 180:479-86 (2004).
RN [4]; RE0038435.
RX PUBMED: 12734330.
RA Takeda A., Hamano S., Yamanaka A., Hanada T., Ishibashi T., Mak T. W., Yoshimura A., Yoshida H.
RT Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
RL J. Immunol. 170:4886-90 (2003).
RN [5]; RE0048376.
RX PUBMED: 12646618.
RA Doyle S. E., O'Connell R., Vaidya S. A., Chow E. K., Yee K., Cheng G.
RT Toll-like receptor 3 mediates a more potent antiviral response than Toll-like receptor 4.
RL J. Immunol. 170:3565-3571 (2003).
RN [6]; RE0048479.
RX PUBMED: 16237061.
RA Yamada A., Sheikh F., Niimi T., DeMayo F. J., Keegan A. D., Donnelly R. P., Kimura S.
RT Induction of uteroglobin-related protein 2 (Ugrp2) gene expression by the Th2 cytokines IL-4 and IL-13.
RL J. Immunol. 175:5708-5715 (2005).
RN [7]; RE0048819.
RX PUBMED: 16785428.
RA Bose R., Molina H., Patterson A. S., Bitok J. K., Periaswamy B., Bader J. S., Pandey A., Cole P. A.
RT Phosphoproteomic analysis of Her2/neu signaling and inhibition.
RL Proc. Natl. Acad. Sci. USA 103:9773-9778 (2006).
RN [8]; RE0049505.
RX PUBMED: 14602726.
RA Townsend P. A., Scarabelli T. M., Davidson S. M., Knight R. A., Latchman D. S., Stephanou A.
RT STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis.
RL J. Biol. Chem. 279:5811-5820 (2004).
RN [9]; RE0052684.
RX PUBMED: 8906870.
RA Philp J. A., Burdon T. G., Watson C. J.
RT Differential activation of STATs 3 and 5 during mammary gland development.
RL FEBS Lett. 396:77-80 (1996).
RN [10]; RE0052859.
RX PUBMED: 17027227.
RA Godeny M. D., Sayyah J., VonDerLinden D., Johns M., Ostrov D. A., Caldwell-Busby J., Sayeski P. P.
RT The N-terminal SH2 domain of the tyrosine phosphatase, SHP-2, is essential for Jak2-dependent signaling via the angiotensin II type AT1 receptor.
RL Cell. Signal. 19:600-609 (2007).
RN [11]; RE0053057.
RX PUBMED: 15983048.
RA Forget G., Gregory D. J., Olivier M.
RT Proteasome-mediated degradation of STAT1alpha following infection of macrophages with Leishmania donovani.
RL J. Biol. Chem. 280:30542-30549 (2005).
RN [12]; RE0053124.
RX PUBMED: 17540171.
RA Liu B., Yang Y., Chernishof V., Loo R. R., Jang H., Tahk S., Yang R., Mink S., Shultz D., Bellone C. J., Loo J. A., Shuai K.
RT Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.
RL Cell 129:903-914 (2007).
RN [13]; RE0053327.
RX PUBMED: 15923602.
RA Proietti C., Salatino M., Rosemblit C., Carnevale R., Pecci A., Kornblihtt A. R., Molinolo A. A., Frahm I., Charreau E. H., Schillaci R., Elizalde P. V.
RT Progestins induce transcriptional activation of signal transducer and activator of transcription 3 (Stat3) via a Jak- and Src-dependent mechanism in breast cancer cells.
RL Mol. Cell. Biol. 25:4826-4840 (2005).
RN [14]; RE0053394.
RX PUBMED: 16301648.
RA Guo Z., Garg S., Hill K. M., Jayashankar L., Mooney M. R., Hoelscher M., Katz J. M., Boss J. M., Sambhara S.
RT A distal regulatory region is required for constitutive and IFN-beta-induced expression of murine TLR9 gene.
RL J. Immunol. 175:7407-7418 (2005).
RN [15]; RE0053637.
RX PUBMED: 18490754.
RA Vargas-Inchaustegui D. A., Xin L., Soong L.
RT Leishmania braziliensis infection induces dendritic cell activation, ISG15 transcription, and the generation of protective immune responses.
RL J. Immunol. 180:7537-7545 (2008).
RN [16]; RE0053797.
RX PUBMED: 16123385.
RA Forrai A., Boyle K., Hart A. H., Hartley L., Rakar S., Willson T. A., Simpson K. M., Roberts A. W., Alexander W. S., Voss A. K., Robb L.
RT Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cells.
RL Stem Cells 24:604-614 (2006).
RN [17]; RE0053999.
RX PUBMED: 12417260.
RA Sur R., Heck D. E., Mariano T. M., Jin Y., Murphy W. J., Laskin J. D.
RT UVB light suppresses nitric oxide production by murine keratinocytes and macrophages.
RL Biochem. Pharmacol. 64:1469-1481 (2002).
RN [18]; RE0055012.
RX PUBMED: 18471880.
RA Dong L. W., Kong X. N., Yan H. X., Yu L. X., Chen L., Yang W., Liu Q., Huang D. D., Wu M. C., Wang H. Y.
RT Signal regulatory protein alpha negatively regulates both TLR3 and cytoplasmic pathways in type I interferon induction.
RL Mol. Immunol. 45:3025-3035 (2008).
RN [19]; RE0055059.
RX PUBMED: 16858407.
RA Johnsen I. B., Nguyen T. T., Ringdal M., Tryggestad A. M., Bakke O., Lien E., Espevik T., Anthonsen M. W.
RT Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling.
RL EMBO J. 25:3335-3346 (2006).
RN [20]; RE0055124.
RX PUBMED: 9794795.
RA Schaper F., Gendo C., Eck M., Schmitz J., Grimm C., Anhuf D., Kerr I. M., Heinrich P. C.
RT Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression.
RL Biochem. J. 335:557-565 (1998).
RN [21]; RE0055294.
RX PUBMED: 18719121.
RA Chen N. J., Chio I. I., Lin W. J., Duncan G., Chau H., Katz D., Huang H. L., Pike K. A., Hao Z., Su Y. W., Yamamoto K., de Pooter R. F., Zuniga-Pflucker J. C., Wakeham A., Yeh W. C., Mak T. W.
RT Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors.
RL Proc. Natl. Acad. Sci. USA 105:12429-12434 (2008).
RN [22]; RE0063497.
RX PUBMED: 18192275.
RA Bai Y., Ahmad U., Wang Y., Li J. H., Choy J. C., Kim R. W., Kirkiles-Smith N., Maher S. E., Karras J. G., Bennett C. F., Bothwell A. L., Pober J. S., Tellides G.
RT Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation.
RL J. Biol. Chem. 283:6832-6842 (2008).
RN [23]; RE0063548.
RX PUBMED: 18339807.
RA Kaur S., Sassano A., Dolniak B., Joshi S., Majchrzak-Kita B., Baker D. P., Hay N., Fish E. N., Platanias L. C.
RT Role of the Akt pathway in mRNA translation of interferon-stimulated genes.
RL Proc. Natl. Acad. Sci. USA 105:4808-4813 (2008).
RN [24]; RE0063709.
RX PUBMED: 18641358.
RA Fielding C. A., McLoughlin R. M., McLeod L., Colmont C. S., Najdovska M., Grail D., Ernst M., Jones S. A., Topley N., Jenkins B. J.
RT IL-6 regulates neutrophil trafficking during acute inflammation via STAT3.
RL J. Immunol. 181:2189-2195 (2008).
RN [25]; RE0064019.
RX PUBMED: 19231233.
RA Seo J. Y., Kim D. Y., Lee Y. S., Ro J. Y.
RT Cytokine production through PKC/p38 signaling pathways, not through JAK/STAT1 pathway, in mast cells stimulated with IFNgamma.
RL Cytokine 46:51-60 (2009).
RN [26]; RE0064165.
RX PUBMED: 18950753.
RA Yamana J., Santos L., Morand E.
RT Enhanced induction of LPS-induced fibroblast MCP-1 by interferon-gamma: involvement of JNK and MAPK phosphatase-1.
RL Cell. Immunol. 255:26-32 (2009).
RN [27]; RE0064247.
RX PUBMED: 19135978.
RA Yamada A., Suzuki D., Miyazono A., Oshima K., Kamiya A., Zhao B., Takami M., Donnelly R. P., Itabe H., Yamamoto M., Kimura S., Kamijo R.
RT IFN-gamma down-regulates Secretoglobin 3A1 gene expression.
RL Biochem. Biophys. Res. Commun. 379:964-968 (2009).
RN [28]; RE0064509.
RX PUBMED: 18641342.
RA Park J. E., Kim Y. I., Yi A. K.
RT Protein kinase D1: a new component in TLR9 signaling.
RL J. Immunol. 181:2044-2055 (2008).
RN [29]; RE0064533.
RX PUBMED: 14976215.
RA Nishiya T., DeFranco A. L.
RT Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors.
RL J. Biol. Chem. 279:19008-19017 (2004).
RN [30]; RE0064812.
RX PUBMED: 15694390.
RA Jeon S. B., Ji K. A., You H. J., Kim J. H., Jou I., Joe E. H.
RT Nordihydroguaiaretic acid inhibits IFN-gamma-induced STAT tyrosine phosphorylation in rat brain astrocytes.
RL Biochem. Biophys. Res. Commun. 328:595-600 (2005).
RN [31]; RE0064924.
RX PUBMED: 16343349.
RA Ehrhart J., Obregon D., Mori T., Hou H., Sun N., Bai Y., Klein T., Fernandez F., Tan J., Shytle R. D.
RT Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation.
RL J. Neuroinflammation 2:29 (2005).
RN [32]; RE0064990.
RX PUBMED: 18715881.
RA Labeur M., Refojo D., Wolfel B., Stalla J., Vargas V., Theodoropoulou M., Buchfelder M., Paez-Pereda M., Arzt E., Stalla G. K.
RT Interferon-gamma inhibits cellular proliferation and ACTH production in corticotroph tumor cells through a novel janus kinases-signal transducer and activator of transcription 1/nuclear factor-kappa B inhibitory signaling pathway.
RL J. Endocrinol. 199:177-189 (2008).
RN [33]; RE0065065.
RX PUBMED: 15604419.
RA Huang A., Zhang Y. Y., Chen K., Hatakeyama K., Keaney JF J. r.
RT Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3.
RL Circ. Res. 96:164-171 (2005).
RN [34]; RE0065138.
RX PUBMED: 16710296.
RA Malakhova O. A., Kim K. I., Luo J. K., Zou W., Kumar K. G., Fuchs S. Y., Shuai K., Zhang D. E.
RT UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity.
RL EMBO J. 25:2358-2367 (2006).
RN [35]; RE0065171.
RX PUBMED: 15649407.
RA Ramana C. V., Kumar A., Enelow R.
RT Stat1-independent induction of SOCS-3 by interferon-gamma is mediated by sustained activation of Stat3 in mouse embryonic fibroblasts.
RL Biochem. Biophys. Res. Commun. 327:727-733 (2005).
RN [36]; RE0065193.
RX PUBMED: 16039576.
RA Kato H., Sato S., Yoneyama M., Yamamoto M., Uematsu S., Matsui K., Tsujimura T., Takeda K., Fujita T., Takeuchi O., Akira S.
RT Cell type-specific involvement of RIG-I in antiviral response.
RL Immunity 23:19-28 (2005).
RN [37]; RE0065206.
RX PUBMED: 18571728.
RA Xu H., An H., Hou J., Han C., Wang P., Yu Y., Cao X.
RT Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages.
RL Mol. Immunol. 45:3545-3552 (2008).
RN [38]; RE0065217.
RX PUBMED: 19508864.
RA Cho H. J., Jin S. M., Son S. M., Kim Y. W., Hwang J. Y., Hong H. S., Mook-Jung I.
RT Constitutive JAK2/STAT1 activation regulates endogenous BACE1 expression in neurons.
RL Biochem. Biophys. Res. Commun. 386:175-180 (2009).
RN [39]; RE0065312.
RX PUBMED: 19846878.
RA Barnholt K. E., Kota R. S., Aung H. H., Rutledge J. C.
RT Adenosine blocks IFN-gamma-induced phosphorylation of STAT1 on serine 727 to reduce macrophage activation.
RL J. Immunol. 183:6767-6777 (2009).
RN [40]; RE0065317.
RX PUBMED: 19414785.
RA Park J. E., Kim Y. I., Yi A. K.
RT Protein kinase D1 is essential for MyD88-dependent TLR signaling pathway.
RL J. Immunol. 182:6316-6327 (2009).
RN [41]; RE0065331.
RX PUBMED: 19542364.
RA Tsai C. C., Kai J. I., Huang W. C., Wang C. Y., Wang Y., Chen C. L., Fang Y. T., Lin Y. S., Anderson R., Chen S. H., Tsao C. W., Lin C. F.
RT Glycogen synthase kinase-3beta facilitates IFN-gamma-induced STAT1 activation by regulating Src homology-2 domain-containing phosphatase 2.
RL J. Immunol. 183:856-864 (2009).
RN [42]; RE0065367.
RX PUBMED: 15284232.
RA Qing Y., Stark G. R.
RT Alternative activation of STAT1 and STAT3 in response to interferon-gamma.
RL J. Biol. Chem. 279:41679-41685 (2004).
RN [43]; RE0065382.
RX PUBMED: 15522878.
RA Qing Y., Costa-Pereira A. P., Watling D., Stark G. R.
RT Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation.
RL J. Biol. Chem. 280:1849-1853 (2005).
RN [44]; RE0065384.
RX PUBMED: 15930175.
RA Hogan J. C., Stephens J. M.
RT Effects of leukemia inhibitory factor on 3T3-L1 adipocytes.
RL J. Endocrinol. 185:485-496 (2005).
RN [45]; RE0065425.
RX PUBMED: 19632985.
RA Dumoutier L., de Meester C., Tavernier J., Renauld J. C.
RT New activation modus of STAT3: a tyrosine-less region of the interleukin-22 receptor recruits STAT3 by interacting with its coiled-coil domain.
RL J. Biol. Chem. 284:26377-26384 (2009).
RN [46]; RE0065477.
RX PUBMED: 18354174.
RA Valledor A. F., Sanchez-Tillo E., Arpa L., Park J. M., Caelles C., LLoberas J., Celada A.
RT Selective roles of MAPKs during the macrophage response to IFN-gamma.
RL J. Immunol. 180:4523-4529 (2008).
RN [47]; RE0065562.
RX PUBMED: 11972023.
RA Nair J. S., DaFonseca C. J., Tjernberg A., Sun W., Darnell JE J. r., Chait B. T., Zhang J. J.
RT Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.
RL Proc. Natl. Acad. Sci. USA 99:5971-5976 (2002).
RN [48]; RE0065662.
RX PUBMED: 16000408.
RA Du Z., Shen Y., Yang W., Mecklenbrauker I., Neel B. G., Ivashkiv L. B.
RT Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway.
RL Proc. Natl. Acad. Sci. USA 102:10267-10272 (2005).
RN [49]; RE0065712.
RX PUBMED: 18362156.
RA Yang C. H., Murti A., Pfeffer S. R., Fan M., Du Z., Pfeffer L. M.
RT The role of TRAF2 binding to the type I interferon receptor in alternative NF kappaB activation and antiviral response.
RL J. Biol. Chem. 283:14309-14316 (2008).
RN [50]; RE0065994.
RX PUBMED: 15166220.
RA Dumoutier L., Tounsi A., Michiels T., Sommereyns C., Kotenko S. V., Renauld J. C.
RT Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling.
RL J. Biol. Chem. 279:32269-32274 (2004).
RN [51]; RE0066419.
RX PUBMED: 11070174.
RA Shimoda K., Kato K., Aoki K., Matsuda T., Miyamoto A., Shibamori M., Yamashita M., Numata A., Takase K., Kobayashi S., Shibata S., Asano Y., Gondo H., Sekiguchi K., Nakayama K., Nakayama T., Okamura T., Okamura S., Niho Y., Nakayama K.
RT Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function.
RL Immunity 13:561-571 (2000).
RN [52]; RE0066483.
RX PUBMED: 19574459.
RA Joshi S., Kaur S., Redig A. J., Goldsborough K., David K., Ueda T., Watanabe-Fukunaga R., Baker D. P., Fish E. N., Fukunaga R., Platanias L. C.
RT Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses.
RL Proc. Natl. Acad. Sci. USA 106:12097-12102 (2009).
RN [53]; RE0066703.
RX PUBMED: 10364426.
RA Li W., Nagineni C. N., Efiok B., Chepelinsky A. B., Egwuagu C. E.
RT Interferon regulatory transcription factors are constitutively expressed and spatially regulated in the mouse lens.
RL Dev. Biol. 210:44-55 (1999).
RN [54]; RE0066749.
RX PUBMED: 20436908.
RA Gough D. J., Messina N. L., Hii L., Gould J. A., Sabapathy K., Robertson A. P., Trapani J. A., Levy D. E., Hertzog P. J., Clarke C. J., Johnstone R. W.
RT Functional crosstalk between type I and II interferon through the regulated expression of STAT1.
RL PLoS Biol. 8:e1000361 (2010).
RN [55]; RE0067038.
RX PUBMED: 20400504.
RA Fletcher T. C., DiGiandomenico A., Hawiger J.
RT Extended anti-inflammatory action of a degradation-resistant mutant of cell-penetrating suppressor of cytokine signaling 3.
RL J. Biol. Chem. 285:18727-18736 (2010).
RN [56]; RE0067449.
RX PUBMED: 16096272.
RA Zvonic S., Baugh JE J. r., Arbour-Reily P., Mynatt R. L., Stephens J. M.
RT Cross-talk among gp130 cytokines in adipocytes.
RL J. Biol. Chem. 280:33856-33863 (2005).
RN [57]; RE0067754.
RX PUBMED: 20051625.
RA Walker E. C., McGregor N. E., Poulton I. J., Solano M., Pompolo S., Fernandes T. J., Constable M. J., Nicholson G. C., Zhang J. G., Nicola N. A., Gillespie M. T., Martin T. J., Sims N. A.
RT Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice.
RL J. Clin. Invest. 120:582-592 (2010).
RN [58]; RE0067764.
RX PUBMED: 16547273.
RA Fritz D. K., Kerr C., Tong L., Smyth D., Richards C. D.
RT Oncostatin-M up-regulates VCAM-1 and synergizes with IL-4 in eotaxin expression: involvement of STAT6.
RL J. Immunol. 176:4352-4360 (2006).
RN [59]; RE0068007.
RX PUBMED: 19651781.
RA Wang X., Zhao Q., Matta R., Meng X., Liu X., Liu C. G., Nelin L. D., Liu Y.
RT Inducible nitric-oxide synthase expression is regulated by mitogen-activated protein kinase phosphatase-1.
RL J. Biol. Chem. 284:27123-27134 (2009).
RN [60]; RE0068170.
RX PUBMED: 17609432.
RA Brender C., Tannahill G. M., Jenkins B. J., Fletcher J., Columbus R., Saris C. J., Ernst M., Nicola N. A., Hilton D. J., Alexander W. S., Starr R.
RT Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.
RL Blood 110:2528-2536 (2007).
RN [61]; RE0068198.
RX PUBMED: 17114427.
RA Owaki T., Asakawa M., Fukai F., Mizuguchi J., Yoshimoto T.
RT IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways.
RL J. Immunol. 177:7579-7587 (2006).
RN [62]; RE0068301.
RX PUBMED: 9711940.
RA Kunisada K., Tone E., Fujio Y., Matsui H., Yamauchi-Takihara K., Kishimoto T.
RT Activation of gp130 transduces hypertrophic signals via STAT3 in cardiac myocytes.
RL Circulation 98:346-352 (1998).
RN [63]; RE0068438.
RX PUBMED: 16966486.
RA Samardzija M., Wenzel A., Aufenberg S., Thiersch M., Reme C., Grimm C.
RT Differential role of Jak-STAT signaling in retinal degenerations.
RL FASEB J. 20:2411-2413 (2006).
RN [64]; RE0068463.
RX PUBMED: 20042582.
RA Matsumoto S., Hara T., Mitsuyama K., Yamamoto M., Tsuruta O., Sata M., Scheller J., Rose-John S., Kado S., Takada T.
RT Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model.
RL J. Immunol. 184:1543-1551 (2010).
RN [65]; RE0068901.
RX PUBMED: 19740326.
RA Hardy P. O., Diallo T. O., Matte C., Descoteaux A.
RT Roles of phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase in the regulation of protein kinase C-alpha activation in interferon-gamma-stimulated macrophages.
RL Immunology 128:e652-60 (2009).
RN [66]; RE0069210.
RX PUBMED: 8592940.
RA Lowe C., Gillespie G. A., Pike J. W.
RT Leukemia inhibitory factor as a mediator of JAK/STAT activation in murine osteoblasts.
RL J. Bone Miner. Res. 10:1644-1650 (1995).
RN [67]; RE0069326.
RX PUBMED: 20231379.
RA Gotoh K., Tanaka Y., Nishikimi A., Nakamura R., Yamada H., Maeda N., Ishikawa T., Hoshino K., Uruno T., Cao Q., Higashi S., Kawaguchi Y., Enjoji M., Takayanagi R., Kaisho T., Yoshikai Y., Fukui Y.
RT Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.
RL J. Exp. Med. 207:721-730 (2010).
RN [68]; RE0069424.
RX PUBMED: 19712053.
RA Lin H. W., Levison S. W.
RT Context-dependent IL-6 potentiation of interferon- gamma-induced IL-12 secretion and CD40 expression in murine microglia.
RL J. Neurochem 111:808-818 (2009).
RN [69]; RE0069876.
RX PUBMED: 17618271.
RA Takaoka A., Wang Z., Choi M. K., Yanai H., Negishi H., Ban T., Lu Y., Miyagishi M., Kodama T., Honda K., Ohba Y., Taniguchi T.
RT DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response.
RL Nature 448:501-505 (2007).
RN [70]; RE0070066.
RX PUBMED: 20696842.
RA Martin P., Gomez M., Lamana A., Cruz-Adalia A., Ramirez-Huesca M., Ursa M. A., Yanez-Mo M., Sanchez-Madrid F.
RT CD69 association with Jak3/Stat5 proteins regulates Th17 cell differentiation.
RL Mol. Cell. Biol. 30:4877-4889 (2010).
RN [71]; RE0070678.
RX PUBMED: 20531401.
RA Weintz G., Olsen J. V., Fruhauf K., Niedzielska M., Amit I., Jantsch J., Mages J., Frech C., Dolken L., Mann M., Lang R.
RT The phosphoproteome of toll-like receptor-activated macrophages.
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RN [72]; RE0071018.
RX PUBMED: 12582176.
RA Malakhov M. P., Kim K. I., Malakhova O. A., Jacobs B. S., Borden E. C., Zhang D. E.
RT High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction.
RL J. Biol. Chem. 278:16608-16613 (2003).
RN [73]; RE0072077.
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RT Ligand-stimulated downregulation of the alpha interferon receptor: role of protein kinase D2.
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