AC T00997
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ID T00997
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DT 25.01.1994 (created); ewi.
DT 21.08.2014 (updated); hna.
CO Copyright (C), QIAGEN.
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FA SRY
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SY sex-determining region Y gene product; TDF; testis-determining factor.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G000388 SRY; HGNC: SRY.
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CL C0015; HMG; 4.1.1.1.1.
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FF testis-determining factor;
FF isolated mutants causing XY females: V60L, M64I, G95R, K106I;
FF recognizes sharp angles in DNA (60-120 deg) irrespective of sequence;
FF when binding to AACAAAG consensus, it produces a sharp bend;
FF mutants with different DNA-binding properties (affinity or induction of structural deformations) have been found in patients with gonadal dysgenesis [3];
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IN T09538 Smad3; Mammalia.
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MX M08899 V$SOX_Q4.
MX M01014 V$SOX_Q6.
MX M00148 V$SRY_01.
MX M00160 V$SRY_02.
MX M08976 V$SRY_12.
MX M03854 V$SRY_Q6.
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BS R07253.
BS R07254.
BS R07255.
BS R07256.
BS R07257.
BS R07258.
BS R07259.
BS R07260.
BS R07261.
BS R07262.
BS R07263.
BS R07264.
BS R07265.
BS R07266.
BS R07267.
BS R07268.
BS R07269.
BS R07270.
BS R07271.
BS R07272.
BS R07273.
BS R07274.
BS R07275.
BS R63411.
BS R63506.
BS R63438.
BS R63466.
BS R03578.
BS R04588.
BS R04593.
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DR TRANSPATH: MO000025328.
DR UniProtKB: Q05066;
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RN [1]; RE0000305.
RX PUBMED: 1425584.
RA Ferrari S., Harley V. R., Pontiggia A., Goodfellow P. N., Lovell-Badge R., Bianchi M. E.
RT SRY, like HMG1, recognizes sharp angles in DNA
RL EMBO J. 11:4497-4506 (1992).
RN [2]; RE0002703.
RX PUBMED: 1734522.
RA Harley V. R., Jackson D. I., Hextall P. J., Hawkins J. R., Berkovitz G. D., Sockanathan S., Lovell-Badge R., Goodfellow P. N.
RT DNA binding activity of recombinant SRY from normal males and XY females
RL Science 255:453-456 (1992).
RN [3]; RE0003119.
RX PUBMED: 7813448.
RA Pontiggia A., Rimini R., Harley V. R., Goodfellow P. N., Lovell-Badge R., Bianchi M. E.
RT Sex-reversing mutations affect the architecture of SRY--DNA complexes
RL EMBO J. 13:6115-6124 (1994).
RN [4]; RE0005078.
RX PUBMED: 8159753.
RA Giese K., Pagel J., Grosschedl R.
RT Distinct DNA-binding properties of the high mobility group domain of murine and human SRY sex-determining factors
RL Proc. Natl. Acad. Sci. USA 91:3368-3372 (1994).
RN [5]; RE0005081.
RX PUBMED: 7774012.
RA Werner M. H., Huth J. R., Gronenborn A. M., Clore G. M.
RT Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRY-DNA complex
RL Cell 81:705-714 (1995).
RN [6]; RE0047886.
RX PUBMED: 15527767.
RA Grimsby S., Jaensson H., Dubrovska A., Lomnytska M., Hellman U., Souchelnytskyi S.
RT Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity.
RL FEBS Lett. 577:93-100 (2004).
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